Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects

Shiota, Satomi; Katoh, Masako; Fujii, Mitsuhiro; Aoki, Shigeyuki; Matsuoka, Rokuro; Fukuchi, Yoshinosuke

doi:10.1111/j.1440-1843.2005.00703.x

Cited by 53 publications

(68 citation statements)

References 23 publications

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“…However, each IOS parameter may be influenced by subject age, in addition to height, according to 2 normative population studies. 30,31 Moreover, the predictive equations of IOS parameters in the Japanese population have not been well established. To exclude the effect of age, the authors calculated the corrected R5eR20 by dividing it by R5.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological characteristics of asthma in the elderly: a comprehensive study

Inoue

Niimi

Takeda

et al. 2014

Annals of Allergy, Asthma & Immunology

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Section: Discussionmentioning

confidence: 99%

Pathophysiological characteristics of asthma in the elderly: a comprehensive study

Inoue

Niimi

Takeda

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…Upper limits of normal for R 5 (3.96 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] (0.76 cmH 2 O/L/s) and AX (3.6 cmH 2 O/L) were chosen to approximate the upper limit of the 95% confidence interval (9,(30)(31)(32)(33)(34). Data for change in IOS parameters in response to methacholine is presented as absolute numeric change to allow analysis of the relative contribution of changes in R20 and R5-20 to the observed change in R5.…”

Section: Discussionmentioning

confidence: 99%

Disparity Between Proximal and Distal Airway Reactivity During Methacholine Challenge

Segal¹,

Goldring²,

Oppenheimer³

et al. 2011

COPD: Journal of Chronic Obstructive Pulmonary Disease

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There is an increasing awareness of the role of distal airways in the pathophysiology of obstructive lung diseases including asthma and chronic obstructive pulmonary disease. We hypothesize that during induced bronchoconstriction: 1) disparity between distal and proximal airway reactivity may occur; and 2) changes in distal airway function may explain symptom onset in subjects with minimal FEV(1) change. 185 subjects underwent methacholine challenge testing (MCT). In addition to spirometry, oscillometry was performed at baseline and after maximum dose of methacholine; 33/185 also underwent oscillometry after each dose. Oscillometric parameters included resistance at 5 and 20 Hz (R(5), R(20)) and heterogeneity of distal airway mechanics assessed by frequency dependence of resistance 5-20 Hz (R(5-20)) and reactance area (AX). R(5) varied widely during MCT (range -0.8 - 11.3 cmH(2)O/L/s) and correlated poorly with change in FEV(1) (r = 0.17). Changes in R(5) reflected changes in both R(20) and R(5-20) (r = 0.59, p<0.05; r = 0.87, p<0.0001). However, R(20) increased only 0.3 cmH(2)O/L/s, while R(5-20) increased 0.7 cmH(2)O/L/s for every 1cmH(2)O/L/s change in R(5,) indicating predominant effect of distal airway mechanics. 9/33 subjects developed symptoms despite minimal FEV(1) change (<5%), while R(5) increased 42% due to increased distal airway heterogeneity. These data indicate disparate behavior of proximal airway resistance (FEV(1) and R(20)) and distal airway heterogeneity (R(5-20) and AX). Distal airway reactivity may be associated with methacholine-induced symptoms despite absence of change in FEV(1). This study highlights the importance of disparity between proximal and distal airway behavior, which has implications in understanding pathophysiology of obstructive pulmonary diseases and their response to treatment.

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“…Conservative upper limits of normal (ULN) were selected that approximate 150% of mean data in normal subjects. 9,15,[25][26][27][28] Data obtained in our laboratory in 80 asymptomatic nonsmoking subjects with normal spirometry and without lung disease fell within these limits.…”

Section: Impulse Oscillometrymentioning

confidence: 92%

Lessons From the World Trade Center Disaster

Berger

Reibman

Oppenheimer

et al. 2013

Chest

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Background: The present study (1) characterizes a physiologic phenotype of restrictive dysfunction due to airway injury and (2) compares this phenotype to the phenotype of interstitial lung disease (ILD). Methods: This is a retrospective study of 54 persistently symptomatic subjects following World Trade Center (WTC) dust exposure. Inclusion criteria were reduced vital capacity (VC), FEV 1 /VC . 77%, and normal chest roentgenogram. Measurements included spirometry, plethysmography, diffusing capacity of lung for carbon monoxide (D LCO ), impulse oscillometry (IOS), inspiratory/expiratory CT scan, and lung compliance (n 5 16). Results: VC was reduced (46% to 83% predicted) because of the reduction of expiratory reserve volume (43% Ϯ 26% predicted) with preservation of inspiratory capacity (IC) (85% Ϯ 16% predicted). Total lung capacity (TLC) was reduced, confi rming restriction (73%

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Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects

Abstract: It was possible to determine a predictive equation and confirm a high degree of reliability of IOS parameters in Japanese adult subjects.

Cited by 53 publications

References 23 publications

Pathophysiological characteristics of asthma in the elderly: a comprehensive study

Pathophysiological characteristics of asthma in the elderly: a comprehensive study

Disparity Between Proximal and Distal Airway Reactivity During Methacholine Challenge

Lessons From the World Trade Center Disaster

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