Predictive epidemiological and clinical factors of nasopharyngeal carcinoma diagnosis: Adult versus pediatric population

Hasnaoui, Mehdi; Lahmar, Rihab; Mabrouk, Asma Ben; Masmoudi, Mohamed; Mighri, Khalifa; Driss, Nabil

doi:10.1016/j.ijporl.2020.110203

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Most of the publications present European data ( 5 , 11 – 13 , 19 , 22 – 28 , 35 , 42 , 43 , 45 – 48 , 50 – 52 , 55 – 58 , 61 ) of which the majority were from the UK ( 11 – 13 , 19 , 22 – 24 , 26 – 28 , 43 , 45 – 47 , 49 – 51 , 55 , 56 , 58 , 61 ). Eight of the selected papers were from lower or middle income countries ( 18 , 20 , 21 , 30 , 31 , 33 , 34 , 36 ), seven from the USA ( 32 , 37 – 39 , 41 , 54 , 60 ), three from Canada ( 40 , 44 , 53 ) and one from Australia ( 59 ).…”

Section: Summarising the Resultsmentioning

confidence: 99%

“…Some papers referred specifically to a type of HNC, often rare like sino-nasal ( 46 , 48 ) and nasopharyngeal carcinoma ( 18 , 21 , 30 , 33 , 60 ); a number of studies concentrated on HPV positive and negative oropharyngeal cancer ( 22 , 25 , 32 , 39 , 41 , 54 ) and oral cancers ( 20 , 29 , 36 ), with one including both ( 35 ). Studies on multiple HNC subtypes based on suspected cancer referrals often had a small minority with diagnosed cancer ( 5 , 11 – 13 , 24 , 26 , 28 , 43 – 45 , 50 – 52 , 55 , 58 , 61 ).…”

Section: Summarising the Resultsmentioning

confidence: 99%

“…The aims of the studies can be categorised into the following: explorations for the reasons for delay in diagnosis or presentation ( 19 , 20 , 22 , 23 , 29 – 32 , 36 , 39 , 40 , 44 , 45 , 47 , 59 , 60 ), the relationship between presenting symptoms and outcomes ( 18 , 21 , 25 – 28 , 37 , 38 , 42 , 46 , 48 , 49 , 51 – 54 , 56 , 57 ), the predictive factors (including symptoms and risk factors) for an eventual diagnosis of a HNC ( 33 – 35 , 41 ), development of statistical models to assist referrals for suspected cancer ( 11 – 13 , 43 ). A small number of the published papers present an assessment of the fast track referral systems for suspected cancer ( 5 , 24 , 50 , 55 , 58 , 61 ) (only one from outside the UK ( 5 )).…”

Section: Summarising the Resultsmentioning

confidence: 99%

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Nomenclature of the symptoms of head and neck cancer: a systematic scoping review

Bradley,

Lee,

Albutt

et al. 2024

Front. Oncol.

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IntroductionEvolution of a patient-reported symptom-based risk stratification system to redesign the suspected head and neck cancer (HNC) referral pathway (EVEREST-HN) will use a broad and open approach to the nomenclature and symptomatology. It aims to capture and utilise the patient reported symptoms in a modern way to identify patients’ clinical problems more effectively and risk stratify the patient.MethodThe review followed the PRISMA checklist for scoping reviews. A search strategy was carried out using Medline, Embase and Web of Science between January 1st 2012 and October 31st 2023. All titles, abstracts and full paper were screened for eligibility, papers were assessed for inclusion using predetermined criteria. Data was extracted pertaining to the aims, type of study, cancer type, numbers of patients included and symptoms, presenting complaints or signs and symptoms.ResultsThere were 9,331 publications identified in the searches, following title screening 350 abstracts were reviewed for inclusion and 120 were considered for eligibility for the review. 48 publications met the eligibility criteria and were included in the final review. Data from almost 11,000 HNC patients was included. Twenty-one of the publications were from the UK, most were retrospective examination of patient records. Data was extracted and charted according to the anatomical area of the head and neck where the symptoms are subjectively and objectively found, and presented according to lay terms for symptoms, clinical terms for symptoms and the language of objective clinical findings.DiscussionSymptoms of HNC are common presenting complaints, interpreting these along with clinical history, examination and risk factors will inform a clinician’s decision to refer as suspected cancer. UK Head and Neck specialists believe a different way of triaging the referrals is needed to assess the clinical risk of an undiagnosed HNC. EVEREST-HN aims to achieve this using the patient history of their symptoms. This review has highlighted issues in terms of what is considered a symptom, a presenting complaint and a clinical finding or sign.

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Section: Summarising the Resultsmentioning

confidence: 99%

Section: Summarising the Resultsmentioning

confidence: 99%

Section: Summarising the Resultsmentioning

confidence: 99%

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Nomenclature of the symptoms of head and neck cancer: a systematic scoping review

Bradley,

Lee,

Albutt

et al. 2024

Front. Oncol.

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“…Approximately 60-90% of patients with NPC reported a neck mass as the first symptom at the initial diagnosis. In the subsequent course of the disease, symptoms of the noses (30-70%) and ears (20-45%) have been found to be more common (8,(11)(12)(13)(14). In our study, neck masses were frequently presented in both groups (73.7% in the children group vs. 59.4% in the adolescent group), and the symptom of epistaxis in the adolescent group was more usual compared to the children group (37.5% vs. 10.5%).…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of clinical features and prognosis of nasopharyngeal carcinoma in children and adolescents

et al. 2022

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ObjectivesTo investigate the clinical characteristics and prognosis of nasopharyngeal carcinoma (NPC) in children and adolescents in different age groups.Materials and methodsThe clinical data of 51 patients with NPC aged ≤ 18 years who were treated in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2012 to May 2017 were retrospectively analyzed. The patients were divided into children group (≤12 years old) and adolescent group (12–18 years old) with 12 years old as the boundary. The clinical characteristics, diagnosis, treatment, and prognosis of the children and adolescent groups were compared.ResultsThe symptoms of the first diagnosis in the children group were mainly nasal congestion (P = 0.043) and ear symptoms (P = 0.008). The diagnosis rate of nasopharyngeal biopsy in the children group was lower (P = 0.001), while the rate of diagnosis of cervical mass biopsy was significantly higher than that in the adolescent group (P = 0.009). The proportion of keratinizing squamous cell carcinoma of the children group was higher than that of the adolescent group (P = 0.006). There was no significant difference in TNM stage and risk stratification between the two groups, but the number of cases in the III-IVa children group who received induction chemotherapy + concurrent chemoradiotherapy was less than that in the adolescent group (P = 0.013). The proportion of radiotherapy in the upper and lower cervical lymph node drainage areas was lower than that in the adolescent group (P = 0.001). The percentage of recurrence and metastasis in the children group was higher than that in the adolescent group (P = 0.026).ConclusionThe diagnosis in the children group depended on endoscopic biopsy and neck mass biopsy, and the proportion of keratinizing squamous cell carcinoma was higher. The number of cases of induction chemotherapy and concurrent chemoradiotherapy in the children group was less than that in the adolescent group, and the proportion of radiotherapy in the upper and lower cervical lymph node drainage areas was lower than that in the adolescent group. Clinically, it is necessary to improve the understanding of the clinical characteristics of children with NPC and take appropriate treatment strategies.

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Nasopharyngeal Carcinoma in Pediatric and Adolescent Patients

Ugurluer,

Mustafayev,

Ozyar

2023

Medical Radiology

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Predictive epidemiological and clinical factors of nasopharyngeal carcinoma diagnosis: Adult versus pediatric population

Cited by 3 publications

References 17 publications

Nomenclature of the symptoms of head and neck cancer: a systematic scoping review

Nomenclature of the symptoms of head and neck cancer: a systematic scoping review

Retrospective analysis of clinical features and prognosis of nasopharyngeal carcinoma in children and adolescents

Nasopharyngeal Carcinoma in Pediatric and Adolescent Patients

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