Predictive diagnostics of lymph nodes metastatic lesion in patients with gastric adenocarcinoma

Кутилин, Денис С.; Tatimov, Martin Zamirovich; Maslov, Andrey A.; Франциянц, Е. М.; Водолажский, Д. И.

doi:10.21886/2219-8075-2018-9-1-51-62

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Одним из наиболее частых вариантов распространения опухолевого процесса при РЖ является лимфогенное метастазирование. Более 50 % больных РЖ при первичной постановке диагноза уже имеют метастатическое поражение регионарных лимфатических узлов (РЛУ), что на 30 % снижает показатели 5-летней выживаемости в данной группе пациентов [4][5][6]. Правильное стадирование опухолевого процесса является ключевым моментом в определении тактики специализированного лечения что приводит к повышению его эффективности.…”

Section: Introductionunclassified

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Ashimov,

Chichevatov,

Radovsky

et al. 2024

Malignant Tumours

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The search for biological markers to assess metastatic involvement of the lymph nodes in gastric cancer is one of the key steps in determining treatment tactics. The role of Ki-67 as a marker of cell proliferation in gastric cancer remains relevant. The aim of our study is to determine the Ki-67 threshold value for predicting the lymph nodes metastases. A retrospective analysis of 154 patients with gastric cancer showed an independent and statistically significant relationship between the depth of tumor invasion T (p = 0.002), the differentiation grade G (p = 0.010), the value of the Ki-67 index (p < 0.0001) and metastatic involvement of the lymph nodes. Using ROC analysis we found that Ki-67 ≥ 45 % correlates with the optimal level of sensitivity (55.9 %), specificity (84.2 %) and accuracy (73.4 %) of the method AUC 0.738 (p >< 0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients>< 0.0001) and metastatic involvement of the lymph nodes. Using ROC analysis we found that Ki-67 ≥ 45 % correlates with the optimal level of sensitivity (55.9 %), specificity (84.2 %) and accuracy (73.4 %) of the method AUC 0.738 (p < < 0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients >0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients with Ki-67 > 45 %, we found that the median OS was 32 months [HR 2.2; 95 % CI 1.2–3,9; p = 0.005], while it was not reached in the group with Ki-67 < 45 %.A Ki-67 level of ≥ 45 % is the optimal threshold for determining the likelihood of lymph node metastasis in gastric cancer.

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Section: Introductionunclassified

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Ashimov,

Chichevatov,

Radovsky

et al. 2024

Malignant Tumours

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Centralization of pathoanatomical service, standardization of intravital pathoanatomical studies in oncology

Максимов¹,

Maksimov

Novikova³

et al. 2019

Vestnik Roszdravnadzora

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Poor resource support of the pathoanatomical service, a lack of training of medical and nursing staff, poor results of pathological and anatomical research, and personnel shortage in some territories and republics of the country have been observed for more than 30 years. The reference centers organized in 2019 will contribute to the centralization of the pathoanatomical service and improve its work in general, which will lead to more efficient use of medical personnel due to the load streamlining, interchangeability, automation of manual labor, and complete and rational use of equipment, as well as will shorten the time for surgical and biopsy material testing.

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Predictive diagnostics of lymph nodes metastatic lesion in patients with gastric adenocarcinoma

Cited by 2 publications

References 2 publications

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Centralization of pathoanatomical service, standardization of intravital pathoanatomical studies in oncology

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