Predictive coding and adaptive behavior in patients with genetically determined cerebellar ataxia––A neurophysiology study

Tunc, Sinem; Baginski, Nastasja; Lubs, Juliane; Bally, Julien; Weissbach, Anne; Baaske, Magdalena K.; Tadić, Vera; Brüggemann, Norbert; Bäumer, Tobias; Beste, Christian; Münchau, Alexander

doi:10.1016/j.nicl.2019.102043

Cited by 8 publications

(18 citation statements)

References 66 publications

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“…Peterburs et al, 2015 reported that ERN amplitude negatively correlated with grey matter volume in the cerebellum right lobule V and left lobule VIIb/VIIIa. Moreover, Pe amplitude was found to be lower in CA patients (Tunc et al,2019) and higher in CL patients (Peterburs et al, 2012) as compared to healthy controls. No differences in Pe amplitude between CD and controls were reported (Peterburs et al, 2015).…”

Section: Cerebellar Dysfunctionmentioning

confidence: 84%

“…The third study reported spared ERN amplitude in cerebellar ataxia (Tunc et al, 2019), which includes different types of spinocerebellar ataxia. The task used was the Flanker Task.…”

Section: Discussionmentioning

confidence: 94%

“…However, it is important to observe that the ACC may not have a prominent role in Pe generation, as shown by unaltered Pe in patients with ACC lesion (Maier et al, 2015) and AD (Ito et al, 2005). Among basal ganglia disorders, Pe was reduced in focal lesion (Ullsperger and Von Cramon, 2006) and TS (Tunc et al, 2019) patients. It should be noted that the Ullsperger group reported reduced Pe in lateral PFC lesion patients, and in 5 out of 7 patients, the lesion extended to the insula (Ullsperget et al, 2002;Ullsperger and Von Cramon, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…A study on patients affected by cerebellar ataxia (CA; Tunc et al, 2019) reported no differences in ERN amplitude between CA and controls, while two studies conducted by the Peterburs group revealed lower ERN in amplitude in patients with cerebellar lesion (CL; Peterburs et al, 2012) and cerebellar degeneration (CD; Peterburs et al, 2015). No alteration of ERN latency was reported in CL (Peterburs et al, 2012).…”

Section: Cerebellar Dysfunctionmentioning

confidence: 98%

“…The task used in the study on CA by Tunc et al (2019) was a Flanker task while the Antisaccade Task was the experimental task for CL and CD studies (Peterburs et al, 2012(Peterburs et al, , 2015…”

Section: Cerebellar Dysfunctionmentioning

confidence: 99%

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New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases

Lenzoni

Baker

Sumich

et al. 2021

Reviews in the Neurosciences

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Error monitoring allows for the efficient performance of goal-directed behaviors and successful learning. Furthermore, error monitoring as a metacognitive ability may play a crucial role for neuropsychological interventions, such as rehabilitation. In the past decades, research has suggested two electrophysiological markers for error monitoring: the error-related negativity (ERN) and the error positivity (Pe), thought to reflect, respectively, error detection and error awareness. Studies on several neurological diseases have investigated the alteration of the ERN and the Pe, but these findings have not been summarized. Accordingly, a systematic review was conducted to understand what neurological conditions present alterations of error monitoring event-related potentials and their relation with clinical measures. Overall, ERN tended to be reduced in most neurological conditions while results related to Pe integrity are less clear. ERN and Pe were found to be associated with several measures of clinical severity. Additionally, we explored the contribution of different brain structures to neural networks underlying error monitoring, further elaborating on the domain-specificity of error processing and clinical implications of findings. In conclusion, electrophysiological signatures of error monitoring could be reliable measures of neurological dysfunction and a robust tool in neuropsychological rehabilitation.

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Section: Cerebellar Dysfunctionmentioning

confidence: 84%

“…The third study reported spared ERN amplitude in cerebellar ataxia (Tunc et al, 2019), which includes different types of spinocerebellar ataxia. The task used was the Flanker Task.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Cerebellar Dysfunctionmentioning

confidence: 98%

Section: Cerebellar Dysfunctionmentioning

confidence: 99%

See 3 more Smart Citations

New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases

Lenzoni

Baker

Sumich

et al. 2021

Reviews in the Neurosciences

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The Neurophysiology of the Cerebellum in Emotion

Adamaszek

Kirkby

2022

The Emotional Cerebellum

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The Role of the Human Cerebellum for Learning from and Processing of External Feedback in Non-Motor Learning: A Systematic Review

Berlijn,

Huvermann,

Schneider

et al. 2024

Cerebellum

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This review aimed to systematically identify and comprehensively review the role of the cerebellum in performance monitoring, focusing on learning from and on processing of external feedback in non-motor learning. While 1078 articles were screened for eligibility, ultimately 36 studies were included in which external feedback was delivered in cognitive tasks and which referenced the cerebellum. These included studies in patient populations with cerebellar damage and studies in healthy subjects applying neuroimaging. Learning performance in patients with different cerebellar diseases was heterogeneous, with only about half of all patients showing alterations. One patient study using EEG demonstrated that damage to the cerebellum was associated with altered neural processing of external feedback. Studies assessing brain activity with task-based fMRI or PET and one resting-state functional imaging study that investigated connectivity changes following feedback-based learning in healthy participants revealed involvement particularly of lateral and posterior cerebellar regions in processing of and learning from external feedback. Cerebellar involvement was found at different stages, e.g., during feedback anticipation and following the onset of the feedback stimuli, substantiating the cerebellum’s relevance for different aspects of performance monitoring such as feedback prediction. Future research will need to further elucidate precisely how, where, and when the cerebellum modulates the prediction and processing of external feedback information, which cerebellar subregions are particularly relevant, and to what extent cerebellar diseases alter these processes.

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Predictive coding and adaptive behavior in patients with genetically determined cerebellar ataxia––A neurophysiology study

Cited by 8 publications

References 66 publications

New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases

New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases

The Neurophysiology of the Cerebellum in Emotion

The Role of the Human Cerebellum for Learning from and Processing of External Feedback in Non-Motor Learning: A Systematic Review

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