Predictive biomarkers of breast ductal carcinomain situmay underestimate the risk of recurrence due tode novoipsilateral breast carcinoma development
Tanjina Kader,
Maia Zethoven,
Sakshi Mahale
et al.
Abstract:Purpose: Development of ipsilateral breast carcinoma following a diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not be the case and it is important to know how often recurrences are new primary tumours to ensure appropriate individualised therapy. Experimental Design: Ipsilateral primary-recurrence pairs (n=78) were sequenced to test their clonal relatedness. Shared genetic events were identified from whole exome sequencing … Show more
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