Predictive assays for the therapy of rectum carcinoma

Combined Treatment with 2-Deoxy-D-Glucose and Doxorubicin Enhances the in Vitro Efficiency of Breast Cancer Radiotherapy

“…2DG treatment was also shown to increase metabolic oxidative stress (Lee et al, 1998;Butt et al, 2000;Spitz et al, 2000;Lin et al, 2003). Such a stress can generate reactive oxygen species, which are capable of inducing Akt phosphorylation (Streffer et al, 1986;Esposito et al, 2003). Our study showed that 500µM 2DG treatment 4 hours prior to irradiation augmented the effects of radiation with relation to the treatment dose per fraction in cancer radiotherapy, higher than 2DG alone, and successfully reduced the cell viability.…”

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

“…Mitotic catastrophe (MC) has been reported as a prominent response to different anticancer drugs that affect cytoskeletal components and include microtubule toxins (Tounekti et al, 1993;Lock and Stribinskiene, 1996;Torres and Horwitz, 1998;Taylor et al, 2006), radiotherapy (Streffer et al, 1986;Falkvoll, 1990;Zolzer et al, 1995;Bhattathiri et al, 1998;Widel et al, 1999) and chemotherapy (Yashige et al, 1999). Cell cycle checkpoint inhibitors in combination with DNA-damaging agents enhance MC by inducing 'mitotic slippage'.…”

The Vasculature of Xenotransplanted Human Melanomas and Sarcomas on Nude Mice

“…As a result, there has been an increasing demand for an individual biological assessment [Strefferet al, 1986], and great efforts have been made to define parameters for predicting tumor curability [Denekamp. 1984;Streffer et al. 1986; Peters e ta l., 1986], A major factor influencing the efficacy of tumor ther apy, particularly in the case of radio-and chemotherapy as well as hyperthermia, is the oxygen tension in tissues [Kaplan.…”