Neuropsychological testing has a unique and important role in (a) delineating the behavioral consequences of brain lesions and (b) predicting the likely impact of such ability deficits on everyday functioning. Here we review the available studies that relate neuropsychological test scores to aspects of self-care and independent living, academic achievement, and vocational functioning. The results are generally positive, but the clinical value of these studies is limited by the fact that most used only intelligence tests or screening tests with subject groups that are not very representative of the patient population referred for neuropsychological testing. Methodological considerations for future research are discussed, in addition to the potential advantages of clinical over actuarial prediction in this area. To illustrate this type of clinical interpretation and suggest hypotheses for future research, it is described how results on comprehensive neuropsychological testing can be considered in relation to questions about patients' everyday functioning.