Predictive and prognostic values of preoperative platelet parameters in patients with gynecological tumors

Yang, Wei; Chen, Yingying; Bi, Chen; Shu, Kuangyi; Ye, Man-Li; Li, Fanfan; Chen, Jie; Wang, Xiaoou; Chen, Xiaojian

doi:10.1002/jcla.23295

Cited by 10 publications

(8 citation statements)

References 33 publications

(44 reference statements)

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“…The result of the 95% CI of AUC of PLT: 1.000-1.000 may be due to the small sample size of this study, and further evaluation is needed to increase the sample size. These results are consistent with the study byYang et al 20 .…”

Section: Discussionsupporting

confidence: 94%

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

Wang

Tao

Zhang

et al. 2022

Clin Appl Thromb Hemost

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Objective:To investigate the application value of bone marrow megakaryocyte count, the proportion of megakaryocytes at each stage, and the platelet parameter in the clinical diagnosis of primary immune thrombocytopenia (ITP). Methods: The megakaryocyte and platelet parameter level in 62 ITP and 40 control group patients were compared and analyzed. Linear correlation analysis, Pearson correlation analysis, and ROC curves were performed for the correlation between megakaryocytes and platelet parameters. Results: Compared to the control group, the total number of megakaryocytes, the promegakaryocytes the granular megakaryocytes (GMeg), and naked megakaryocytes (NMeg), MPV, and P-LCR% in the ITP group increased. All differences were statistically significant ( P<0.05). While the proportion of platelet-producing megakaryocytes (PMeg), PLT, and PCT decreased in the ITP group. These differences were statistically significant ( P < 0.05). PLT was strongly positively correlated with PCT (r = 0.921, p<0.01). PCT was weakly positively with MPV (r = 0.309, p<0.05). MPV was positively correlated with P-LCR (r = 0.856, p<0.01). PDW was weakly positively correlated with P-LCR (r = 0.296, p<0.05) and Meg (r = 0.301, p<0.05), and negatively correlated with PMeg (r = -0.336, p<0.05). ROC curve analysis showed that PLT, PCT MPV and P-LCR% gave a high sensitivity（100.0%，81.0%，74.6%，90.5%，respectively.) and specificity (100.0%, 92.5%, 80.0%, 77.5%, respectively.) in diagnosis of ITP. Conclusion: The combined analysis of bone marrow megakaryocyte count, the proportion of megakaryocyte classification at each stage, and platelet parameters have an important reference value for auxiliary diagnosis of ITP.

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Section: Discussionsupporting

confidence: 94%

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

Wang

Tao

Zhang

et al. 2022

Clin Appl Thromb Hemost

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“…The increase in neutrophil count is stimulated by inflammatory cytokines to promote neutrophil phagocytic and bactericidal effects, which provides the "fuel that feeds the flames" of tumor growth and metastasis (25,26). Several studies have confirmed the prognostic value of PLT count in lung cancer, gynecologic malignancies, melanoma, and hepatocellular carcinoma (27)(28)(29)(30)(31)(32). PLTs have been suggested to mediate antigen presentation by dendritic cells to T cells (33) and form heterotypic aggregates with neutrophils (34).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of systemic immune-inflammation index and platelet-albumin-bilirubin grade in patients with pancreatic cancer undergoing radical surgery

Han¹,

Tian²,

Jiang³

et al. 2022

Gland Surg

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Background: Systemic inflammatory markers are associated with patient survival in pancreatic cancer (PC).The aim of this study was to investigate the prognostic significance of the systemic immune-inflammation index (SII) in PC patients who underwent radical surgery. Platelet-albumin-bilirubin (PALBI) grade is a composite evaluation index based on liver function. Patients with pancreatic head cancer are prone to obstructive jaundice, which leads to abnormal liver function. Based on this, we also explored the prognostic value of PALBI grade in PC patients.Methods: Patients with pathologically confirmed PC who had undergone radical surgery (with negative surgical margin) for the first time at the Affiliated Hospital of Qingdao University from January 2013 to December 2019 and followed up by December 2020 were retrospectively analyzed. Peripheral blood cell count is easily affected by infection or hematological diseases, which affects the results, so it is excluded.Clinical data and laboratory examination indexes were collected. The SII and PALBI grade were calculated.The cutoff values were determined using the Youden index. The Cox proportional hazards regression model was used to analyze the prognostic value of the SII and PALBI grade through univariate and multivariate survival analysis.Results: A total of 214 patients [median age, 60.29 years; 128 (59.8%) men] met the inclusion criteria.There were 140 patients (65.4%) with pancreatic head cancer according to the tumor location. They were divided into high and low SII or PALBI groups by cutoff values of 705 and −5.6, respectively. According to the multivariate analysis, SII (P<0.001) was an independent factor negatively associated with overall survival (OS) and disease-free survival (DFS). In patients with pancreatic head cancer, PALBI grade was associated with shorter OS (P=0.031). The combination of high SII and high PALBI grade had stronger predictive value for poor prognosis (log-rank test, P<0.001), which the OS was 11.3 months less than the combination of low two groups.Conclusions: SII was a promising prognostic biomarker in PC. And PALBI grade also showed predictive value for patients with pancreatic head cancer. Therefore, it can help predict the treatment outcomes in these patients

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“…89 The argument that supports the roles attributed to platelets in ovarian carcinomas, especially in high-grade serous ones, is the result of published studies, which consistently identify, preoperatively, the presence of thrombocytosis. 38,90,92,93 The circulating platelet excess can be explained by the role of these acellular figured elements, as reactants of inflammation, the hyperproduction being induced by the pro-inflammatory cytokines: IL-1, IL-6, and IL-11. 40,94 The involvement of platelets in the process of carcinogenesis and associated inflammation results from the action they induce at the level of sphingolipids of cell membranes, represented mainly by ceramides (CER), glucosylceramide (GlcCer), sphingosine (SPH), and sphingosine-1-phosphate (S1P) 95 Selectively, cellular oxidative stress is a stimulating factor of sphingosine and/or ceramide synthesis, and among these, the distinctive role in modulating the process of development, progression, metastasis, and even in the chemoresistance of neoplasia, belongs to CER.…”

Section: The Relationship Between the Chronic Inflammatory Process An...mentioning

confidence: 99%

Systemic inflammation factors as survival prognosis markers in ovarian neoplasm and the relationship with cancer-associated inflammatory mediators—a review

Dinca

Diaconu

Bîrlă

et al. 2023

Int J Immunopathol Pharmacol

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At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and mortality. In the specialized literature, the coexistence of an inflammatory process is admitted from the early stages of the evolution of this pathology. Starting from the importance of this process, both in determinism and in the evolution of carcinogenesis and summarizing the field of knowledge, for this study we considered two objectives: the first was the presentation of the pathogenic mechanism, through which chronic +ovarian inflammation is involved in the process of carcinogenesis, and the second is the justification of the clinical utility of the three parameters, accepted as biomarkers of systemic inflammation: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and lymphocyte-monocyte ratio in the assessment of prognosis. The study highlights the acceptance of these hematological parameters, with practical utility, as prognostic biomarkers in ovarian cancer, based on the intrinsic link with cancer-associated inflammatory mediators. Based on the data from the specialized literature, the conclusion is that in ovarian cancer, the inflammatory process induced by the presence of the tumor, induces changes in the types of circulating leukocytes, with immediate effects on the markers of systemic inflammation.

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Predictive and prognostic values of preoperative platelet parameters in patients with gynecological tumors

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 33 publications

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

Prognostic significance of systemic immune-inflammation index and platelet-albumin-bilirubin grade in patients with pancreatic cancer undergoing radical surgery

Systemic inflammation factors as survival prognosis markers in ovarian neoplasm and the relationship with cancer-associated inflammatory mediators—a review

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