Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer

Abstract

Purpose: To determine the utility of preoperative complete blood count (CBC) based systemic infl ammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods: Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results: Mean age of the tumor and control group was 36.0±15 and 30.50±11 years, respectively. Mean RDW, NR and NLR were signifi cantly higher in the tumor group with p values<0.001; whereas LR and MPV were signifi cantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specifi city = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specifi city 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specifi city=55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion: Several systemic infl ammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers.

Comprehensive Assessment of Selected Immune Cell Subpopulations Changes in Chemotherapy-Naïve Germ Cell Tumor Patients

“…The vast majority of the studies evaluating immune perturbations in the context of cancer have focused on the increase of the immature and immunosuppressive myeloid populations ( 33 ). Previous studies have evaluated the prognostic or predictive value of specific markers, which were easily retrieved from blood tests performed routinely, such as those assessing the number of neutrophils, leukocytes and platelets in various malignant tumors, including GCTs ( 24 – 26 , 40 – 43 ). With the exception of these markers, the alterations of several other peripheral immune lineages were involved in this process.…”

Can Hematological Parameters Play a Role in the Differential Diagnosis of Adrenal Tumors?

“…Cancer-inflammation-related processes in tumors are associated with the production of cytokines (IL-6 and TNF-α), growth factors, and granulocyte colonystimulating factors in oncology patients [3]. The systemic inflammatory responses are associated with thyroid, pancreas, and many endocrine organ malignancies, as well as in urogenital malignancies such as prostate and testis [9][10][11][12]. Furthermore, the association of inflammatory response with hypertension, diabetes mellitus, and many systemic diseases has also been demonstrated [13].…”

“…Hematological parameters such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), red cell distribution width (RDW), which are used as indicators of acute and chronic inflammation, are effective in the diagnosis and prediction of inflammatory disease and some malignancies [3,11,17,18]. There have been few studies reported with conflicting results in the use of NLR, PLR, RDW, etc.…”

Bladder Cancer highlighted

“…Dr Arda and Collegues ( 5 ) from Turkey perfomed on page 216 in a interesting determined the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis in 182 patients and concluded that several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperatively achieved testicular tumor markers.…”