Predictive Accuracy of MCI Subtypes for Alzheimer’s Disease and Vascular Dementia in Subjects with Mild Cognitive Impairment: A 2-Year Follow-Up Study

Rasquin, S.M.C.; Lodder, J.; Visser, Pieter Jelle; Lousberg, Richel; Verhey, Frans R.J.

doi:10.1159/000082662

Cited by 171 publications

(161 citation statements)

References 38 publications

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“…50 In a clinical study, the amnestic MCI and multiple-domain MCI subtype was as a predictor of both AD and VD, with no significant differences between these outcome. 51 A large proportion of subjects classified as having MCI can resume normal cognitive function (backconversion or diagnostic instability) or maintain stable cognitive deficits, not progressing to dementia even on long-term followup. 44 In some studies, the rate of backconversion reached up to 40% of patients with MCI.…”

Section: Longitudinal Studies and MCI Prognosismentioning

confidence: 99%

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

Forlenza

Diniz

Stella

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short-and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based on the search terms mild cognitive impairment or MCI and epidemiology or diagnosis, we retrieved 1,698 articles, of which 248 were critically eligible (cross-sectional and longitudinal studies); the abstracts of the remaining 1,450 articles were also reviewed. Results: A critical review on the MCI construct is provided, including conceptual and diagnostic aspects; epidemiological relevance; clinical assessment; prognosis; and outcome. The distinct definitions of cognitive impairment, MCI included, yield clinically heterogeneous groups of individuals. Those who will eventually progress to dementia may present with symptoms consistent with the definition of MCI; conversely, individuals with MCI may remain stable or return to normal cognitive function. Conclusion: On clinical grounds, the cross-sectional diagnosis of MCI has limited prognostic relevance. The characterization of persistent and/or progressive cognitive deficits over time is a better approach for identification of cases at the pre-dementia stages, particularly if these cognitive abnormalities are consistent with the natural history of incipient Alzheimer's disease.

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Section: Longitudinal Studies and MCI Prognosismentioning

confidence: 99%

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

Forlenza

Diniz

Stella

et al. 2013

Rev. Bras. Psiquiatr.

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“…Subdivisions between different cognitive subtypes of MCI, amnestic versus nonamnestic, and single versus multi-domain, have implications for inference about aetiology and outcomes. Indeed, while a-MCI (Petersen, 2007) is thought to be a precursor of AD, nonamnestic subtypes of MCI have been found to identify individuals at high risk of both AD and VaD (Rasquin et al, 2005).…”

Section: Cognitive Profilementioning

confidence: 99%

Vascular Dementia and Alzheimer's Disease: Is There a Difference?

Ramdane¹

2012

Neurodegeneration

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“…In the expanded MCI concept, 2 it was not defined-besides the broad categories amnestic vs nonamnestic, single vs multiple domains-which specific cognitive domains are affected. In an earlier clinical study, 14 nine cognitive domains were measured. In the Cardiovascular Health Study (CHS) Cognition Study, 15 six cognitive domains were assessed.…”

Section: 2mentioning

confidence: 99%

Minocycline-induced skin and dental pigmentations

Mozaffar¹,

Gordon²

2006

Neurology

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Abstract-Objective:To empirically validate the expanded concept of mild cognitive impairment (MCI), which differentiates between four clinical subtypes-amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCIsingle domain, and nonamnestic MCI-multiple domains-and to examine the prevalence, course, and outcome of these four clinical MCI subtypes. Methods: We studied a community sample of 980 dementia-free individuals aged 75 years or older who participated in the Leipzig Longitudinal Study of the Aged (LEILA 75ϩ). All participants were examined by neuropsychological testing based on 6 years of observation. The diagnoses of the four clinical MCI subtypes were made according to the original and to slightly modified criteria by Petersen et al. (2001) (both with a cutoff of 1.0 SD and with a cutoff of 1.5 SD). The complete range of outcome types (dementia, death, improvement, stable diagnosis, unstable diagnosis) was described for all subtypes. The relative predictive power of stable MCI for dementia onset was determined. Results: MCI-single domain is more frequent than MCI-multiple domains, and the nonamnestic MCI type is as frequent as the amnestic MCI type. The "MCI modified, 1.0 SD" criteria have the highest relative predictive power for the development of dementia (sensitivity ϭ 74%, specificity ϭ 73%). Alzheimer disease (AD) was the most common type of dementia at follow-up in all but one MCI subtype. Participants with nonamnestic MCI-multiple domains were more likely to progress to a non-AD dementia. Conclusions: It has been assumed that each MCI subtype is associated with an increased risk for a particular type of dementia. We can only partially agree with this. NEUROLOGY 2006;67:2176-2185 The expanded concept of mild cognitive impairment (MCI) distinguishes four clinical subtypes: amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCI-single domain, and nonamnestic MCI-multiple domains. 1,2These four clinical subtypes assumedly differ in etiology and outcome.1,2 Amnestic MCI (single domain as well as multiple domains) is said to have a high likelihood of progressing to Alzheimer disease (AD) dementia. The nonamnestic subtypes are assumed to have a higher likelihood of progressing to a non-AD dementia. 1,2This study addresses several questions. What is the prevalence of the subtypes of MCI? Which types of dementia do the subtypes of MCI commonly relate to? In this study, we also examine the course of and 6-year outcome of MCI in a representative general population sample aged 75 years and older, and describe the complete range of outcome types (dementia, death, improvement, stable diagnosis, unstable diagnosis).Method. Sample. The data were derived from the Leipzig Longitudinal Study of the Aged (LEILA 75ϩ), a population-based study of the epidemiology of dementia and MCI.3 All subjects gave written informed consent to participate in this study. The local ethics committee approved this study. The total LEILA 75ϩ sample was comprised of a total of 1,692 community-dwelling ...

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Predictive Accuracy of MCI Subtypes for Alzheimer’s Disease and Vascular Dementia in Subjects with Mild Cognitive Impairment: A 2-Year Follow-Up Study

Cited by 171 publications

References 38 publications

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

Vascular Dementia and Alzheimer's Disease: Is There a Difference?

Minocycline-induced skin and dental pigmentations

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