Predictive ability of C-reactive protein for early mortality after ischemic stroke: comparison with NIHSS score

Ghabaee, Mojdeh; Zandieh, Ali; Mohebbi, Shahrzad; Fakhri, Mohammad; Sadeghian, Homa; Divani, Fatemeh; Amirifard, Hamed; Mousavi-Mirkala, Mohammadreza; Ghaffarpour, Majid

doi:10.1007/s13760-013-0238-y

Cited by 18 publications

(20 citation statements)

References 32 publications

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“…In particular, CRP levels >2.2 mg/L were found to be associated with high mortality in these cases. 9 However, in the current study, there was no statistically significant difference between the mortality and discharged groups in terms of CRP levels even though the former group had a relatively higher CRP value )p=0.48(. Previous studies reported that the area of ischemic infarct presenting with restricted diffusion in diffusion-weighted MR imaging is important for the prediction of some neurological deficits as well as for prognosis.…”

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confidence: 63%

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The role of radiologic, clinical and biochemical parameters in prediction of stroke mortality

Algın

Inan

2019

NSJ

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Objectives: To assess National Institutes of Health Stroke Scale)NIHSS(, stroke volume, biochemical, and blood parameters for the prediction of onemonth mortality in stroke patients. Methods: The study had retrospective design and 75 patients were involved that presented to a hospital Emergency Department between January 2016 and December 2017 in Adiyaman, Turkey diagnosed with acute ischemic cerebral infarction. The patients were divided into 2 groups according to whether mortality occurred within one month. Values for NIHSS, stroke volume, Glasgow Coma Scale, and blood parameters were compared between the groups. Results: Values for Glasgow Coma Scale p=0.002, NIHSS p=0.001, stroke volume p=0.003, monocyte/ HDL ratio p=0.047, neutrophils p=0.01, white blood cell p=0.007, calcium p=0.016, and albumin p=0.027 were statistically significant for the prediction of onemonth mortality. There were no significant differences between the groups for other parameters. Conclusion: The clinical, laboratory, and radiological findings individually provide significant support for the short-term prognosis of stroke. The evaluation of these results together can provide a clearer advance understanding of a prognosis to better manage the course of the disease and prevent death.

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confidence: 63%

“…Ghabaee et al 9 reported that CRP value and NIHSS score had a high sensitivity for mortality prediction in stroke cases. In particular, CRP levels >2.2 mg/L were found to be associated with high mortality in these cases.…”

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confidence: 99%

The role of radiologic, clinical and biochemical parameters in prediction of stroke mortality

Algın

Inan

2019

NSJ

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“…This hypothesis has been observed in several clinical studies, with the high levels of serum Hcy as independent predictors for END for stroke patients [11, 14]. However, a recent study suggested conflicting results, demonstrating no association between elevated Hcy levels and functional outcome among elderly patients with acute cerebral infarction [15].…”

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confidence: 83%

“…The serum Hcy levels were found to be significantly higher in stroke patients than those of normal controls [11-13]. Also, the high levels of serum Hcy were independent predictors for early neurological deterioration (END) and death in multivariate analysis [14], with the prognostic accuracy of 0.83 and 0.82, respectively [11]. These findings suggest that Hcy may be an effective biomarker for early diagnosis and prognosis of lacunar infarction.…”

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confidence: 99%

Assessment of Homocysteine as a Diagnostic and Early Prognostic Biomarker for Patients with Acute Lacunar Infarction

Fan

Yang

et al. 2017

Eur Neurol

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Background: Although increasing evidence has demonstrated that elevated homocysteine (Hcy) levels may be an important contributor for the development of cerebral infarction, rare studies focused on its diagnostic and early prognostic roles in acute lacunar infarction. Methods: A total of 197 patients with acute lacunar infarction and 192 to form the control group were prospectively recruited between January 2013 and February 2017. Early neurological deterioration was defined as an increase of ≥2 points in National Institutes of Health Stroke Scale or the decrease in Barthel index (BI) score at discharge. Results: Univariate and multivariate logistic regression analyses revealed that higher levels of fibrinogen and Hcy were independently clinical predictors associated with lacunar infarction. Receiver operating characteristic curves analysis demonstrated that the diagnosis value of Hcy was superior to fibrinogen, with the area under the curve of 0.881 and 0.688 respectively. Using the optimal cutoff value of 15.5 μmol/L of Hcy, a sensitivity of 65% and a specificity of 100% were achieved for predicting lacunar infarction. Hcy was only significantly related with BI reduction in the males (30.5 [15.5–65.5] vs. 18 [15–24], p = 0.034) in the univariate analysis but not in the females and the multivariate analysis. Conclusions: Serum Hcy may be an independent diagnostic and not an early prognostic biomarker for patients with acute lacunar infarction.

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“…Some have shown that only younger age and localized disease (27), tumor diameter less than 25 mm (10), and low-grade histology (5,10,12) were associated with better prognoses and that surgery and adjuvant radiotherapy may not influence overall survival (27), while others have focused on the role of gross total resection, refusing a long-term role for adjuvant therapy (9), both in benign pineocytomas (2,(6)(7)(8)13) and pineoblastomas (28). Some other studies, nonetheless, have shown a beneficial role for adjuvant therapy, either alone (4) or after gross total surgical resection (15,17,22).…”

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Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

Motiei-Langroudi¹,

Sadeghian²,

Soleimani³

et al. 2014

Turkish Neurosurgery

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Because optimal therapeutic strategies vary with tumor type, a histologic diagnosis by either stereotactic or endoscopic biopsy or open surgery is the foundation of management decisions. Stereotactic biopsy has the advantage of ease and minimal invasiveness but is associated with more sampling errors than open surgery (19), while open resection facilitates maximal removal of tumor volume with more diagnostic accuracy. However, all surgical procedures in the pineal region, including both stereotactic biopsy and open surgery, are potentially hazardous (3,11). █ INTRODUCTIONPineal region tumors represent 0.4-1.0% of intracranial tumors and can harbor highly diverse histologic tumor subtypes, including germ cell, pineal parenchymal, and glial tumors (21).The tumor manifestations are the consequence of their pressure effects and consist of visual disturbances, headache, mental deterioration, Parinaud's syndrome, non-communicating hydrocephalus, and sometimes dementia-like behavior. MATERIAL and METHODS:We present the results of 48 patients with pineal tumor treated either by stereotactic biopsy followed by adjuvant therapy (23 patients) or open surgical resection without (18 patients) or with (7 patients) adjuvant therapy in Shohada Tajrish Hospital, Iran (1993.RESULTS: unremarkable pathology yield was 3/23 in the biopsy and 1/25 in the surgical group. Perioperative mortality and morbidity were 4.3% and 0% in the biopsy group and 32.0% and 4.0% in the surgical group. Analysis showed that age, gender, cranial nerve deficit, motor deficit, preoperative Karnofsky Performance Score (KPS), midbrain involvement, and brain stem involvement had no effect on neither perioperative mortality nor long-term survival, while local invasion and pineocytoma pathology increased perioperative mortality and presence of hydrocephalus and pineoblastoma pathology significantly decreased long-term survival. Hospitalization length was shorter in the stereotactic biopsy plus adjuvant therapy group. CONCLUSION:The results of the study suggests that although gross total resection is the standard of care in most pineal tumors nowadays, stereotactic biopsy followed by adjuvant therapy may still be a safe and viable option.

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Predictive ability of C-reactive protein for early mortality after ischemic stroke: comparison with NIHSS score

Cited by 18 publications

References 32 publications

The role of radiologic, clinical and biochemical parameters in prediction of stroke mortality

The role of radiologic, clinical and biochemical parameters in prediction of stroke mortality

Assessment of Homocysteine as a Diagnostic and Early Prognostic Biomarker for Patients with Acute Lacunar Infarction

Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

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