Prediction of Ventricular Mechanics After Pulmonary Valve Replacement in Tetralogy of Fallot by Biomechanical Modeling: A Step Towards Precision Healthcare

Patient-specific closed-loop model of the fontan circulation: Calibration and validation

“…We have demonstrated the feasibility of creating an accurate, subject-specific, 1-D/0-D model of pulsatile blood flow in the Fontan circulation using clinical data from combined cardiac catheterisation and cardiac magnetic resonance exams (i.e., an iCMR exam). Previous models have shown promise in contributing to the optimal management of other congenital heart diseases [ 34 , 35 ]. Our model could enhance the state-of-the-art assessment of Fontan haemodynamics provided by iCMR exams by (i) augmenting the data with flow and pressure signals at locations where no in vivo signals are available, and (ii) providing a mechanistic understanding of how different haemodynamic measurements relate to each other, both at the time of the exam and in virtual clinical scenarios.…”

Right Heart Catheterisation with Dobutamine Stress Test for Evaluation of Right Ventricular Outflow Tract Obstruction 30 Years After Surgical Repair of Tetralogy of Fallot

“…Recent studies have suggested the usefulness of novel methods to evaluate the severity of repaired TOF. 9,10 Future studies are necessary to establish the indications for reoperation in patients with and without RVOTO.…”

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

“…The cross-bridge cycle is represented in terms of transitions within a kinetic system comprising two [ 93 ], three [ 94 , 95 ], four [ 28 , 96 ], or more (e.g., [ 97 – 99 ]) states. In the hybrid approach by Gusseva et al [ 100 ], a Hill-type model is used where the active behaviour of the myocardium is modelled within Huxley’s filament theory. In general, the computational cost increases with complexity and is typically much higher with Huxley-type models compared to Hill-type models.…”

“…Similarly, to translate mechanical behaviour from the cellular to the anatomical level, in [ 165 , 166 ] the authors coupled the mechanical model of MyoSim to a simple hemispherical representation of the LV. In [ 100 ], Gusseva et al combined a hybrid Hill-Huxley model with a spherical representation of the RV in a cohort of Tetralogy of Fallot patients after pulmonary valve replacement, to assess the predictive value of the mechanics models before and after replacement using a transversely isotropic material law.…”