Prediction of tumor-specific splicing from somatic mutations as a source of neoantigen candidates
Franziska Lang,
Patrick Sorn,
Martin Suchan
et al.
Abstract:Splicing is dysregulated in many tumors and may result in tumor-specific transcripts that can encode neoantigens, which are promising targets for cancer immunotherapy. Detecting tumor-specific splicing is challenging because many non-canonical splice junctions identified in tumor transcriptomes also appear in healthy tissues. However, somatic mutations can disrupt canonical splicing motifs or create novel ones leading to true tumor-specific targets. Here, we developed splice2neo to integrate the predicted spli… Show more
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