Prediction of troponin I and N-terminal pro-brain natriuretic peptide levels in acute carbon monoxide poisoning using advanced electrocardiogram analysis, Alexandria, Egypt

Aziz, Manal Hassan Abdel; Dine, Fatma Mohamed Magdy Badr El; Hussein, Heba Abdel Samie Mohamed; Abdelazeem, Ahmed Mokhtar; Sanad, Israa Mahmoud

doi:10.1007/s11356-021-14171-3

Cited by 5 publications

(5 citation statements)

References 53 publications

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“…Similar to our findings, Turan et al reported that NT-proBNP was predictive of myocardial injury in children with CO poisoning [ 32 ]. In addition, in a study by Abdel Aziz et al it was stated that troponin-I did not differ in patients with mild, moderate, or severe CO poisoning and that NT-proBNP was more valuable than troponin-I in demonstrating myocardial damage [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

et al. 2022

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Aims In this study, cardiac biomarkers, blood parameters, electrocardiography (ECG), and echocardiography were investigated in children with carbon monoxide (CO) poisoning, and the diagnostic value of these parameters was investigated. Methods The demographical, clinical, and laboratory data of children aged 0–18 years who were admitted to the pediatric emergency department due to CO poisoning between January 2019 and January 2022 were retrospectively scanned from medical records. The patients were divided into two groups as troponin-I positive and troponin-I negative. Results There were 107 children aged 0–18 years (average age, 10.46 ± 5.77 years; 51% female) with CO poisoning. There were 13 patients with troponin-I positive myocardial injury. Troponin-I was positive in 3 patients whose carboxyhemoglobin (COHb) level was below 2% at the time of admission. In one patient, troponin-I, which was normal at admission, increased by the 24th hour of hospitalization. Hyperbaric oxygen therapy was given due to headache in one patient, although the COHb level of that patient was below 25%. An NT-proBNP level of ≥ 219.5 ng/L predicted the development of troponin-I positivity with a sensitivity of 70% and a specificity of 86.7% (AUC, 0.967 (0.58–0.994); p = 0.017). White blood cell (WBC), neutrophil, neutrophil-to-lymphocyte ratio (NLR), immature granulocyte (IG), and IG% levels were found to be significantly higher in the troponin-positive patient group. Discussion and conclusion NT-proBNP has been shown to be an early diagnostic marker for myocardial dysfunction. Additionally, when cardiac markers are not available, full blood parameters may assist clinicians for patient treatment and referral.

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Section: Discussionmentioning

confidence: 99%

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

et al. 2022

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“…It can lower the risk of heart problems and increase overall survival [ 19 ]. BNP levels also show predictive power for the development of delayed neurological sequelae (DNS), which are severe consequences impairing cognitive and motor functions, even though they have a stronger correlation with poor neurologic outcomes in acute CO poisoning [ 32 , 48 , 51 , 52 ].…”

Section: Main Bodymentioning

confidence: 99%

“…In CO poisoning, a combination of BNP and highly sensitive troponin I (hsTnI) can improve prognostic value and diagnostic accuracy [ 17 , 23 , 53 ]. Additionally, ECG values have a strong predictive capacity for BNP and troponin I levels, which helps patients with CO poisoning detect and avoid cardiac toxicity early [ 51 ].…”

Section: Main Bodymentioning

confidence: 99%

Cardiovascular biomarkers: exploring troponin and BNP applications in conditions related to carbon monoxide exposure

Taghdiri

2024

Egypt Heart J

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Background The diagnosis and prognosis of cardiovascular disorders are greatly aided by cardiovascular biomarkers. The uses of troponin and B-type natriuretic peptide in situations involving carbon monoxide exposure are examined in this narrative review. These biomarkers are important because they help predict outcomes in cardiovascular disorders, track the effectiveness of therapy, and influence therapeutic choices. Main body Clinical practice makes considerable use of B-type natriuretic peptide (BNP), which has diuretic and vasodilatory effects, and troponin, a particular marker for myocardial injury. Carbon monoxide (CO) poisoning is a major worldwide health problem because CO, a “silent killer,” has significant clinical consequences. Higher risk of cardiac problems, poorer clinical outcomes, and greater severity of carbon monoxide poisoning are all linked to elevated troponin and B-type natriuretic peptide levels. BNP’s adaptability in diagnosing cardiac dysfunction and directing decisions for hyperbaric oxygen therapy is complemented by troponin’s specificity in identifying CO-induced myocardial damage. When combined, they improve the accuracy of carbon monoxide poisoning diagnoses and offer a thorough understanding of cardiac pathophysiology. Conclusions To sum up, this review emphasizes the importance of troponin and B-type natriuretic peptide (BNP) as cardiac indicators during carbon monoxide exposure. While BNP predicts long-term cardiac problems, troponin is better at short-term morbidity and death prediction. When highly sensitive troponin I (hsTnI) and B-type natriuretic peptide are combined, the diagnostic accuracy of carbon monoxide poisoning patients is improved. One of the difficulties is evaluating biomarker levels since carbon monoxide poisoning symptoms are not always clear-cut. Accurate diagnosis and treatment depend on the investigation of new biomarkers and the use of standardized diagnostic criteria. The results advance the use of cardiovascular biomarkers in the intricate field of carbon monoxide exposure.

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“…NT-proBNP is a peptide hormone discharged by ventricular cells in reaction to augmented tension within the ventricular walls (18). Manal et al reported that carbon monoxide can increase NT-proBNP levels (19). Drug treatment for breast cancer can also cause an increase in NT-proBNP levels (20).…”

Section: Introductionmentioning

confidence: 99%

Association of urinary bisphenol A levels with heart failure risk in U.S. adults from the NHANES (2003–2016)

Ma,

Huang,

Qian

et al. 2024

Front. Cardiovasc. Med.

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IntroductionAlthough heart failure (HF) has been linked to bisphenol A (BPA), few studies have investigated the cut-off values for the effects of urinary BPA levels on heart failure risk. The association between urinary BPA levels and HF prognosis has not been investigated.MethodsThis study included 11,849 adults over 20 years old using information from the National Health and Nutrition Examination Survey (NHANES), which was conducted from 2003 to 2016. The relationship between urinary BPA levels and the risk of HF was determined via a multivariable logistic regression model, and restricted cubic spline (RCS) methods were used to determine the cut-off for the effect of BPA levels on HF risk. Based on the available NT-proBNP concentration data from the NHANES (2003–2004), multivariable linear regression was applied to determine the linear association between the NT-proBNP concentration and urinary BPA concentration.ResultsThe results revealed a positive correlation between a urinary BPA concentration in the fourth quartile and the occurrence of heart failure [OR 1.49, 95% CI (1.09, 2.04), p = 0.012]. A one-unit increase (1 ng/mg creatinine) in the ln-transformed BPA concentration was linked to a 15% increase in the incidence of HF [OR 1.15, 95% CI (1.03, 1.29), p = 0.014]. The cut-off urinary BPA concentration for HF risk was 1.51 ng/mg creatinine. There was a positive correlation between urinary BPA and NT-proBNP concentrations [β = 0.093, 95% CI (0.014, 0.171), p = 0.02] in males, but there was no linear association [β = 0.040, 95% CI (−0.033, 0.113), p = 0.283] in females.DiscussionIncreased urinary BPA levels are linked to an increased risk of heart failure and poor prognosis. There is a significant increase in the risk of heart failure if the urinary concentration of BPA exceeds 1.51 ng/mg creatinine.

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Prediction of troponin I and N-terminal pro-brain natriuretic peptide levels in acute carbon monoxide poisoning using advanced electrocardiogram analysis, Alexandria, Egypt

Cited by 5 publications

References 53 publications

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

Cardiovascular biomarkers: exploring troponin and BNP applications in conditions related to carbon monoxide exposure

Association of urinary bisphenol A levels with heart failure risk in U.S. adults from the NHANES (2003–2016)

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