Prediction of thyroid nodule malignancy using thyroid imaging reporting and data system (TIRADS) and nodule size

Shayganfar, Azin; Hashemi, Peyman; Esfahani, Mahsa Masjedi; Ghanei, Amir Mohammad; Moghadam, N Afshar; Ebrahimian, Shadi

doi:10.1016/j.clinimag.2019.10.004

Cited by 14 publications

(15 citation statements)

References 37 publications

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“…PCTNs whose ultrasound features are between benign and malignant are more difficult to differentiate. Compared with other related studies of solid thyroid nodules ( 10 ), the sensitivity and specificity of TI-RADS for differentiating benign and malignant thyroid nodules were 91.67% and 52.8%. Therefore, compared with solid nodules, PCTNs have a lower sensitivity and higher specificity for ultrasound diagnosis.…”

Section: Discussionmentioning

confidence: 63%

Analysis of Differential Diagnosis of Benign and Malignant Partially Cystic Thyroid Nodules Based on Ultrasound Characterization With a TIRADS Grade-4a or Higher Nodules

Wang

Zhang

et al. 2022

Front. Endocrinol.

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Partially cystic thyroid nodules (PCTNs) are a kind of thyroid nodule with both solid and cystic components, and are usually misdiagnosed as benign nodules. The objective of this study was to determine the ultrasound (US) characterizations with a TIRADS Grade-4a or higher partially cystic thyroid nodules (PCTNs) which are associated with being malignant or benign. In this study, 133 PCTNs with a TIRADS Grade-4a or higher were enrolled; 83 were malignant and 50 were benign. TI-RADS classification can detect malignant PCTNs, and its sensitivity, specificity, positive predictive value, negative predictive value, and accuracy are 39.8%, 96.0%, 94.3%, 49.0%, and 60.9%, respectively. Univariate analyses revealed that nodule shape, margin, and structure were related to PCTNs’ being benign and malignant, among which nodules taller-than-wide, with an irregular shape, non-smooth margin, eccentric sharp angle, or edge sharp angle were significantly associated with malignancy while ovoid to round nodules, smooth margins, multiple separation, and eccentric obtuse angle structures were significantly associated with a benign nature. For the solid part of PCTNs, its free margin, echo, and calcification are related to benign and malignant PCTNs. Among them, the free margin of the solid part is non-smooth, hypoechoic, and microcalcification, which are related to malignant PCTNs, while the free margin of the solid part is smooth, isoechoic, macrocalcification, non-calcification and are related to benign PCTNs. Calcification of solid part and free margin are important factors for predicting malignant PCTNs. In addition, nodules’ composition, blood flow signal, and other factors had nothing to do with PCTNs’ being benign or malignant. In the multivariate Logistic regression analysis, solid part calcification (OR: 17.28; 95%CI: 5.14~58.08) and free margin (OR: 3.18; 95%CI: 1.01~10.00) were revealed to be the strongest independent predictors for malignancy (P<0.05). Our study indicated that understanding the ultrasound characteristics of malignant PCTNs, to avoid misdiagnosed PCTNs patients, is important to make a precise diagnosis and prognosis of PCTNs.

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Section: Discussionmentioning

confidence: 63%

Analysis of Differential Diagnosis of Benign and Malignant Partially Cystic Thyroid Nodules Based on Ultrasound Characterization With a TIRADS Grade-4a or Higher Nodules

Wang

Zhang

et al. 2022

Front. Endocrinol.

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“…In their study, the Bethesda system documented that thyroid nodules with TIRADS > 4 and a diameter lower than 12 mm were highly suspicious for malignancy, with a sensitivity of 91.7% and specificity of 52.8%. They found an inverse relationship between nodular size and malignancy risk [25]. [26].…”

Section: Results From Applying Tiradsmentioning

confidence: 98%

“…Various studies have evaluated the prediction of thyroid malignancy using TIRADS [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Table 3). Shayganfar et al studied 239 thyroid nodules combining TIRADS and FNA outcome using the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) [25]. The BSRTC includes six diagnostic categories including: bon-diagnostic (I); benign and bon-beoplastic (II); atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) (III); follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) (IV); suspicious for malignancy (SM) (V); and malignant (VI) [9].…”

Section: Results From Applying Tiradsmentioning

confidence: 99%

Overview of the Ultrasound Classification Systems in the Field of Thyroid Cytology

Rossi

Pantanowitz

Raffaelli

et al. 2021

Cancers

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The increasing application of ultrasound (US) in recent years has led to a greater number of thyroid nodule diagnoses. Consequently, the number of fine needle aspirations performed to evaluate these lesions has increased. Although the majority of thyroid nodules are benign, identifying methods to define specific lesions and tailor risk of malignancy has become vital. Some of the tools employed to stratify thyroid nodule risk include clinical factors, thyroid US findings, and reporting systems for thyroid cytopathology. Establishing high concordance between US features and cytologic diagnoses might help reduce healthcare costs by diminishing unnecessary thyroid procedures and treatment. This review aims to review radiology US classification systems that influence the practice of thyroid cytology.

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“…4 Nodule size is an important criterion used to evaluate thyroid nodules in adults, and is correlated with risk of malignancy and extent of disease. [10][11][12] However, the impact of thyroid nodule size is less clear in children. As thyroid volume is smaller in young children and increases with age during childhood, thyroid nodule size may have different implications in pediatric populations depending on age and/or thyroid volume.…”

Section: Introductionmentioning

confidence: 99%

“…Nodule size is an important criterion used to evaluate thyroid nodules in adults, and is correlated with risk of malignancy and extent of disease 10–12 . However, the impact of thyroid nodule size is less clear in children.…”

Section: Introductionmentioning

confidence: 99%

Thyroid tumor ratio: Improving the assessment of the impact of size in pediatric thyroid cancer

et al. 2022

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Background The impact of thyroid nodule size is less useful in children who have smaller thyroid volumes than in adults. We investigate using a novel thyroid tumor ratio measurement in children with thyroid cancer. Methods Patient and pathologic characteristics were investigated via Student's t‐test in a univariate analysis for any correlation with the log‐transformed tumor ratio, followed by a multivariate linear regression. Results Of 75 patients with malignancy and tumor ratio information, mean ratio decreased with increasing age (p = 0.04). Out of several clinical factors, patients with lymph node metastases and those treated with postoperative radioactive iodine had significantly higher mean tumor ratios on multivariate analysis (p = 0.04 for both factors). Conclusions Our study is the first to describe thyroid tumor volume in pediatric thyroid cancer and shows that increased tumor ratio was associated with indicators of more advanced disease such as lymph node metastases and use of radioactive iodine.

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Prediction of thyroid nodule malignancy using thyroid imaging reporting and data system (TIRADS) and nodule size

Cited by 14 publications

References 37 publications

Analysis of Differential Diagnosis of Benign and Malignant Partially Cystic Thyroid Nodules Based on Ultrasound Characterization With a TIRADS Grade-4a or Higher Nodules

Analysis of Differential Diagnosis of Benign and Malignant Partially Cystic Thyroid Nodules Based on Ultrasound Characterization With a TIRADS Grade-4a or Higher Nodules

Overview of the Ultrasound Classification Systems in the Field of Thyroid Cytology

Thyroid tumor ratio: Improving the assessment of the impact of size in pediatric thyroid cancer

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