Prediction of the prognosis of patients with bacteremia caused by encapsulated organisms using spleen volume: A retrospective study

Shimoyama, Keiichiro; Azuma, Kazunari; Nakamura, Itaru; Oda, Jun

doi:10.1002/ams2.698

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Splenic atrophy is often accompanied by a decrease in the number of cells and destruction of the histologic structure and may reflect a variety of pathologic conditions (Liu et al., 2017). Smaller spleen volume has been suggested to predict poor prognosis in patients with bacteremia caused by encapsulated organisms (Shimoyama et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

The mechanisms underlying alcohol‐induced decreased splenic size: A network meta‐analysis study

Liu,

Bishir,

Hodgkinson

et al. 2023

Alcohol: Clinical and Experimental Research

View full text Add to dashboard Cite

BackgroundOrgan weight change is widely accepted as a measure of toxicologic pathology. We and other groups have shown that excessive alcohol exposure leads to decreased spleen weight in rodents. This study explores the mechanisms underlying alcohol‐induced splenic injury through a network meta‐analysis.MethodsQIAGEN Ingenuity Pathway Analysis (IPA) and Mammalian Phenotype (MP) Ontology were used to identify alcohol‐related molecules associated with the small spleen phenotype. Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and IPA bioinformatics tools were then used to analyze the biologic processes and enriched signaling pathways engaging these molecules. In addition, the “downstream effects analysis” algorithm was used to quantify alcohol's effects.ResultsIPA identified 623 molecules affected by alcohol and a Venn diagram revealed that 26 of these molecules overlapped with those associated with the MP Ontology of small spleen. The 26 molecules are TGFB1, CASP8, MTOR, ESR1, CXCR4, CAMK4, NFKBIA, DRD2, BCL2, FAS, PEBP1, TRAF2, ATM, IGHM, EDNRB, MDM2, GLRA1, PRF1, TLR7, IFNG, ALOX5, FOXO1, IL15, APOE, IKBKG, and RORA. Some of the 26 molecules were also associated with the MP Ontology of abnormal white pulp and red pulp morphology of the spleen, abnormal splenic cell ratio, decreased splenocyte number, abnormal spleen physiology, increased splenocyte apoptosis, and reduced splenocyte proliferation. STRING and IPA “Core Analysis” showed that these molecules were mainly involved in pathways related to cell apoptosis, proliferation, migration, and immune responses. IPA's “Molecular Activity Predictor” tool showed that concurrent effects of activation and inhibition of these molecules led to decreased spleen size by modulating apoptosis, proliferation, and migration of splenocytes.ConclusionsOur network meta‐analysis revealed that excessive alcohol exposure can damage the spleen through a variety of molecular mechanisms, thereby affecting immune function and human health. We found that alcohol‐mediated splenic atrophy is largely mediated by increased apoptosis signaling, migration of cells, and inhibition of splenocyte proliferation.

show abstract

Section: Introductionmentioning

confidence: 99%