Prediction of the postoperative 90-day mortality after acute colorectal cancer surgery: development and temporal validation of the ACORCA model

Degett, Thea Helene; Christensen, Jane; Dalton, Susanne Oksbjerg; Bossen, Kristine Skovgaard; Frederiksen, Kirsten; Iversen, Lene Hjerrild; Gögenür, Ismail

doi:10.1007/s00384-021-03950-6

Cited by 4 publications

(2 citation statements)

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“…It's a malignant tumor in the colon or rectum, accounting for around two-thirds and one-third of all diagnosed individuals, respectively. About 95% of them are adenocarcinomas of the glandular epithelium 1,2 . Selenium (Se) is a trace element essential for human health.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum Selenium level as a risk factor for Colorectal cancer

Hassan

Albakaa

Hussein

2023

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Selenium, an antioxidant enzyme component, has been shown to protect against colorectal cancer risk. A diet is the primary source of these antioxidants, and selenium level is inversely related to colorectal cancer risk and may be responsible for around 50% of colorectal cancer risk. The study aims to evaluate selenium levels as a marker for colorectal cancer risk. The participants in this study were 180 individuals, comprising patients and healthy people, separated into two distinct groups: The first comprised 90 cases, 47 of them were men, and 43 were female patients. The second group had 90 healthy individuals, including 60 men and 30 women. All individuals were subjected to blood sampling to determine serum selenium by using Flame Atomic Absorption Spectrometer. The mean serum selenium concentration in the colorectal cancer group was significantly lower (P< 0.01) than in healthy control people. The result shows a strong association between low levels of selenium and the risk of colorectal cancer. Keywords: Selenium, Colorectal cancer

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Section: Introductionmentioning

confidence: 99%

Evaluation of serum Selenium level as a risk factor for Colorectal cancer

Hassan

Albakaa

Hussein

2023

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“…In 2016, Usher-Smith JA et al identified eighty-seven risk factors (excluding genes and SNPs) implicated in CRC pathogenesis and thus possibly involved in different models of CRC risk score [8]. Among these, age, gender, and BMI are emerging as reliable predictors to develop CRC [9]. The increasing evidence of a strong association between obesity, male sex, advanced age (and also physical inactivity as well as tobacco use) [10], with a higher risk of CRC has driven the attention of the researchers to investigate the common pathways and clinical features shared between colorectal cancer risk and cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

Expression of Autophagic and Inflammatory Markers in Normal Mucosa of Individuals with Colorectal Adenomas: A Cross Sectional Study among Italian Outpatients Undergoing Colonoscopy

Sena

Mancini

Pedroni

et al. 2022

IJMS

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Colorectal cancer (CRC) ranks among the three most common cancers in terms of both cancer incidence and cancer-related deaths in Western industrialized countries. Lifetime risk of colorectal cancer may reach 6% of the population living in developed countries. In the current era of personalized medicine, CRC is no longer considered as a single entity. In more recent years many studies have described the distinct differences in epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and outcome depending on the anatomical site. The aim of our study is to assess in a multidimensional model the association between metabolic status and inflammatory and autophagic changes in the normal colorectal mucosa classified as right-sided, left-sided and rectum, and the presence of adenomas. One hundred and sixteen patients undergoing colonoscopy were recruited and underwent a complete serum lipid profile, immunofluorescence analysis of colonic biopsies for MAPLC3 and myeloperoxidase expression, matched with clinical and anthropometric characteristics. Presence of adenomas correlated with cholesterol (total and LDL) levels, IL-6 levels, and MAPLC3 tissue expression, especially in the right colon. In conclusion, serum IL-6 amount and autophagic markers could be good predictors of the presence of colorectal adenomas.

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