Prediction of the incidence and persistence of allergic rhinitis in adolescence: A prospective cohort study

Kellberger, Jessica; Dressel, Holger; Vogelberg, Christian; Leupold, W; Windstetter, Doris; Weinmayr, Gudrun; Genuneit, Jon; Heumann, Christian; Nowak, Dennis; Mutius, Erika von; Radon, Katja

doi:10.1016/j.jaci.2011.08.016

Cited by 36 publications

(21 citation statements)

References 46 publications

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“…21,22 This study confirms those observations and additionally shows that the simple detection of preclinical sensitization to grass pollen can allow prediction of the onset of hay fever in an allergen-specific manner. In this case IgE sensitization is indeed not only a risk factor but also a specific disease cause.…”

Section: Discussionsupporting

confidence: 85%

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever

Hatzler

Panetta

Lau

et al. 2012

Journal of Allergy and Clinical Immunology

231

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Section: Discussionsupporting

confidence: 85%

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever

Hatzler

Panetta

Lau

et al. 2012

Journal of Allergy and Clinical Immunology

231

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“…In children, trajectories of allergic diseases or asthma show that longitudinal-based clusters are of interest [30,31]. In adults with AR, differences in disease prevalence exist in longitudinal studies and patients with AR may develop asthma [32].…”

Section: Discussionmentioning

confidence: 99%

Clinical Relevance of Cluster Analysis in Phenotyping Allergic Rhinitis in a Real-Life Study

Bousquet

Devillier

Tadmouri

et al. 2015

Int Arch Allergy Immunol

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Background: Disease stratification, using phenotypic characterization performed either by hypothesis- or data-driven methods, was developed to improve clinical decisions. However, cluster analysis has not been used for allergic rhinitis. Objective: To define clusters in allergic rhinitis and to compare them with ARIA (Allergic Rhinitis and Its Impact on Asthma), a hypothesis-driven approach. Methods: A French observational prospective multicenter study (EVEIL: Echelle visuelle analogique dans la rhinite allergique) was carried out on 990 patients consulting general practitioners for allergic rhinitis and treated as per clinical practice. In this study, changes in symptom scores, visual analogue scales and quality of life were measured at baseline and after 14 days of treatment. A post hoc analysis was performed to identify clusters of patients with allergic rhinitis - using Ward's hierarchical method - and to define their clinical relevance at baseline and after 14 days of treatment. The cluster approach was compared to the ARIA approach. Results: Patients were clustered into 4 phenotypes which partly followed the ARIA classes. These phenotypes differed in their disease severity including symptoms and quality of life. Physicians in real-life practice prescribed medication regardless of the phenotype and severity, with the exception of patients with ocular symptoms. Prescribed treatments were comparable in hypothesis- and data-driven analyses. The prevalence of uncontrolled patients during treatment was similar in the 4 clusters, but was significantly different according to the ARIA classes. Conclusion: Cluster analysis using demographic and clinical parameters only does not appear to add relevant information for disease stratification in allergic rhinitis.

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“…11 Positive SPT to outdoor allergens in adolescence has been shown to be associated with persistent AR. 12 Cat sensitization is associated with asthma and hay fever in young adults. 13 Our second hypothesis is SPT wheal area during the first three years of childhood is a continuous predictor for the future development of AR at age four.…”

Section: Introductionmentioning

confidence: 99%

Traffic pollution is associated with early childhood aeroallergen sensitization

Codispoti

LeMasters

Levin

et al. 2015

Annals of Allergy, Asthma & Immunology

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Prediction of the incidence and persistence of allergic rhinitis in adolescence: A prospective cohort study

Cited by 36 publications

References 46 publications

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever

Clinical Relevance of Cluster Analysis in Phenotyping Allergic Rhinitis in a Real-Life Study

Traffic pollution is associated with early childhood aeroallergen sensitization

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