Prediction of the immunological and prognostic value of five signatures related to fatty acid metabolism in patients with cervical cancer

Abstract

A growing attention has been attached to the role of fatty acid metabolism (FAM) in the development of cancer, and cervical cancer (CC) is still the primary cause of cancer-associated death in women worldwide. Therefore, it is imperative to explore the possible prognostic significance of FAM in CC. In this study, CC samples and corresponding normal samples were acquired from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx). Single sample gene set enrichment analysis (ssGSEA) was conducted for calculating FAM-related scores (FAMRs) to screen FAM-related genes (FAMRGs). Two subtypes related to FAM were identified by consistent clustering. Among them, subtype C2 had a poor prognosis, and C1 had a high level of immune cell infiltration, while C2 had a high possibility of immune escape and was insensitive to chemotherapy drugs. Based on the differentially expressed genes (DEGs) in the two subtypes, a 5-gene signature (PLCB4, FBLN5, TSPAN8, CST6, and SERPINB7) was generated by the least absolute shrinkage and selection operator (LASSO) and Akaike information criterion (AIC). The model demonstrated a high prognostic accuracy (area under the curve (AUC)>0.7) in multiple cohorts and was one independent prognostic factor for CC patients. Accordingly, FAMRGs can be adopted as a biomarker for the prediction of CC patients’ prognosis and help guide the immunotherapy of CC.

Construction and validation of a metabolism-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer

“…In January 2021, Wang Z et al discovered that hypoxia-induced PLOD1 overexpression promotes the malignant phenotype of glioblastoma through NF-κB signaling [ 15 ]. In October 2022, Qiongjing Zeng et al established a prediction model for cervical cancer with five signals including SERPINB7 indicating that SERPINB7 is highly expressed in cervical cancer patients [ 16 ]. As early as September 2012, Wuttig D determined that TSPAN7 is a promising prognostic marker for clear cell renal cell carcinoma and indicated that patients with higher expression of the TSPAN7 gene or those with TSPAN7-positive blood vessels in both cores of tissue microarray studies had significantly longer DFS and tumor-specific survival (TSS) [ 17 ].…”