Prediction of the essential intermolecular contacts for side‐binding of VASP on F‐actin
Fikret Aydin,
Harshwardhan H. Katkar,
Alisha Morganthaler
et al.
Abstract:Vasodilator‐stimulated phosphoprotein (VASP) family proteins play a crucial role in mediating the actin network architecture in the cytoskeleton. The Ena/VASP homology 2 (EVH2) domain in each of the four identical arms of the tetrameric VASP consists of a loading poly‐Pro region, a G‐actin‐binding domain (GAB), and an F‐actin‐binding domain (FAB). Together, the poly‐Pro, GAB, and FAB domains allow VASP to bind to sides of actin filaments in a bundle, and recruit profilin–G‐actin to processively elongate the fi… Show more
We are delighted to introduce the "Physics of the Cytoskeleton" special issue. This collection of 10 contributed papers (seven research articles, two short reports, and a perspective) highlights physical prop-
We are delighted to introduce the "Physics of the Cytoskeleton" special issue. This collection of 10 contributed papers (seven research articles, two short reports, and a perspective) highlights physical prop-
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