Prediction of the Compressive Strength of Human Lumbar Vertebrae

Brinckmann, Paul; Biggemann, M; Hilweg, D

doi:10.1097/00007632-198906000-00012

Cited by 194 publications

(58 citation statements)

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“…A correlation of r = 0.68 was found between BMD and MCS, which increased to r = 0.91 if the area was included. Similar results were found by other authors in in vitro studies [2,14,15].…”

Section: Discussionsupporting

confidence: 93%

“…In both the Mosekilde and Gilsanz studies [4,18] cross-sectional area was larger in the specimens obtained from males and the compressive strength in the Mosekilde study was higher in males due to a larger cross-sectional area, which corresponds to the findings of other biomechanical studies [2,19].…”

Section: Discussionsupporting

confidence: 82%

“…Biomechanical studies analyzing maximum compressive strength of vertebral motion segments obtained from human cadaver spines suggest that the cross-sectional areas of the vertebrae contribute substantially to the strength of the specimens [1,2]. In vivo studies performed by Gilsanz et al [3,4] demonstrated a higher cross-sectional area in men compared with women and a lower cross-sectional area in postmenopausal females with osteoporotic fractures compared with age-matched controls.…”

Section: Introductionmentioning

confidence: 99%

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Cross-sectional Area of Lumbar Vertebrae in Peri- and Postmenopausal Patients With and Without Osteoporosis

Link¹,

Dören

Lewing³

et al. 2000

Osteoporosis International

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The purpose of this study was to analyze the midvertebral area of lumbar vertebrae in osteoporotic and nonosteoporotic female patients and to find out whether the midvertebral area may be used as an additional parameter in the diagnosis of osteoporosis. In 195 peri- and postmenopausal patients (average age 51.7 +/- 5.2 years) trabecular and cortical bone mineral density (BMD) were determined using quantitative CT (QCT) in L2-4. In addition, midvertebral cross-sectional area was measured in a standardized fashion on the CT sections and the height of the second lumbar vertebra was determined on the lateral digital radiographs. Body height and weight were obtained and vertebral fracture status was determined. According to WHO criteria 29 patients (average age 57.2 years) were considered osteoporotic, 93 osteopenic (average age 52.2 years) and 73 normal (average age 48.6 years). Body weight and size did not show significant differences between the individual groups. Average midvertebral area was 1278 +/- 173 mm2 in the osteoporotic patients, 1186 +/- 125 mm2 in the osteopenic patients and 1126 +/- 127 mm2 in the normals. A correlation of r = -0.39 (p < 0.05) was obtained between BMD and area. Thirty-six of 195 patients showed osteoporotic vertebral fractures. Midvertebral area in these patients was 1266 +/- 171 mm2 versus 1159 +/- 133 mm2 in the nonfractured females (p < 0.05). We therefore conclude that the lumbar midvertebral area is larger in osteoporotic and osteopenic patients compared with women with normal BMD. In contrast to biomechanical considerations midvertebral area seems not to be suited as an additional measure of bone strength in vivo.

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“…A correlation of r = 0.68 was found between BMD and MCS, which increased to r = 0.91 if the area was included. Similar results were found by other authors in in vitro studies [2,14,15].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cross-sectional Area of Lumbar Vertebrae in Peri- and Postmenopausal Patients With and Without Osteoporosis

Link¹,

Dören

Lewing³

et al. 2000

Osteoporosis International

View full text Add to dashboard Cite

show abstract

“…The cross-sectional area of the vertebral body is directly correlated with the load-bearing capacity of the vertebral body both during pure compression and during bending loads, which are the two dominating forces on the vertebral body during normal, daily activity (8,9). The cross-sectional area of the vertebral bodies is 20± 30% larger in young men than in women of corresponding ages (5).…”

Section: Cross-sectional Areamentioning

confidence: 99%

Age-related changes in bone mass, structure, and strength – effects of loading

Mosekilde

2000

Z Rheumatol

108

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The incidence of vertebral fracture has increased three- to fourfold for women and more than fourfold for men during the last 30 years. These data are age-adjusted and therefore highlight the decrease in bone mass or bone quality from generation to generation. To arrest or reverse these increases in osteoporotic fractures, effective preventive regimens must be established. However, in order to do so, a basic understanding of age-related changes in the quality and strength of vertebral bone is crucial. In this study, the normal age-related changes in human bone have been investigated by using a combination of different techniques: normal histomorphometry, structural analyses, scanning electron microscopy (SEM), and biomechanical testing. It has been demonstrated that age by itself is the major determinant of vertebral bone strength, mass, and microarchitecture. When the sex-related differences are investigated, three different factors are disclosed: Men have, at the age of 20-30 years, a higher peak bone mass and strength than women. Men show an age-related compensatory increase in bone size (cross-sectional area of the vertebral bodies) which can not be found in women. There is, after the age of 50 years (menopause), a higher tendency for disconnection of the trabecular network in women than in men. Furthermore, it was shown that loading plays an important role in the maintenance of trabecular connectivity (through the remodeling process) and in the periosteal apposition and thereby increase in cross-sectional area (through the modeling process). Loading affects bone mass, microarchitecture, and size throughout life. Loading is therefore important for the maintenance of bone strength during normal aging--and exercise plays an important role in the prevention of osteoporotic fractures.

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“…It was the aim of our study to extend these investigations to the cervical vertebrae. Brinkmann [12] presented a study in which the compressive strength of thoracic as well as lumbar vertebrae was related to their BMD. Other studies, like that of Wittenberg [4], revealed a correlation between the tearing forces of transpedicular screws in lumbar vertebrae and BMD.…”

Section: Resultsmentioning

confidence: 99%

Accuracy of single-energy quantitative computed tomography in the assessment of bone mineral density of cervical vertebrae

et al. 1997

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Earlier studies have shown that single-energy quantitative computed tomography (SEQCT) is a reliable method for bone mineral density (BMD) measurements in thoracic and lumbar vertebrae. Moreover, SEQCT has proved to be a useful parameter in the selection of appropriate implants in cervical spondylodesis. The aim of this study was to determine the accuracy of SEQCT in cervical vertebrae BMD measurement. BMD with reference to calcium hydroxyapatite (Ca10[PO4]6[OH]2) was assessed by SEQCT in 100 human vertebral bodies of the cervical spine. Bone cylinders were then cut from the appropriate region of interest. The cylinder volume was determined by the liquid displacement technique. The density of the mineral component was measured following incineration at 1100 degrees C for 24 h. The calculated BMD was correlated with the SEQCT values, resulting in a coefficient of r = 0.79 (P < 0.01). Mean SEQCT values were significantly lower than those determined by direct density assessment (t-test for coupled sampling, P < 0.02). This result was in agreement with studies on thoracic and lumbar vertebrae. These data suggest that SEQCT can reliably measure BMD in the cervical spine.

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Prediction of the Compressive Strength of Human Lumbar Vertebrae

Cited by 194 publications

References 0 publications

Cross-sectional Area of Lumbar Vertebrae in Peri- and Postmenopausal Patients With and Without Osteoporosis

Cross-sectional Area of Lumbar Vertebrae in Peri- and Postmenopausal Patients With and Without Osteoporosis

Age-related changes in bone mass, structure, and strength – effects of loading

Accuracy of single-energy quantitative computed tomography in the assessment of bone mineral density of cervical vertebrae

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