Prediction of spontaneous preterm delivery in women presenting with premature labor: a comparison of placenta alpha microglobulin-1, phosphorylated insulin-like growth factor binding protein-1, and cervical length

Nikolova, Tanja; Uotila, Jukka; Nikolova, Natasha; Bolotskikh, Vyacheslav M.; Borisova, Vera Y.; Renzo, Gian Carlo Di

doi:10.1016/j.ajog.2018.09.016

Cited by 33 publications

(22 citation statements)

References 41 publications

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“…The currently available biochemical tests such as fetal fibronectin and phosphorylated insulin‐like growth factor binding protein‐1 (phIGFBP1) provide excellent NPVs, but their clinical use is limited and not recommended . Previous studies have shown that PAMG‐1 is a significantly better predictor of PTB within 7 days, compared with phIGFBP1 . A further review, which assessed the accuracy of PAMG‐1, fetal fibronectin, and phIGFBP‐1 tests in predicting PTB, found a PPV for PAMG‐1 that was significantly higher compared with the other two biochemical markers .…”

Section: Discussionmentioning

confidence: 99%

“…16,21 Previous studies have shown that PAMG-1 is a significantly better predictor of PTB within 7 days, compared with phIGFBP1. 28 A further review, which assessed the accuracy of PAMG-1, fetal fibronectin, and phIGFBP-1 tests in predicting PTB, found a PPV for PAMG-1 that was significantly higher compared with the other two biochemical markers. 8 Given the PAMG-1 performance (PPV, NPV, and specificity) in women presenting with threatened PTL symptoms ( Figure 2), we propose that PAMG-1 (rather than other biochemical markers) in combination with CL measurement providing risk stratification, may further contribute to identifying women at risk for PTB.…”

Section: Discussionmentioning

confidence: 99%

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Cervico‐vaginal placental α‐macroglobulin‐1 combined with cervical length for the prediction of preterm birth in women with threatened preterm labor

Radan

Polowy

Heverhagen

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Preterm birth is a major cause of neonatal morbidity and mortality. There is an urgent need to accurately predict imminent delivery to enable necessary interventions such as tocolytic, glucocorticoid, and magnesium sulfate administration. We aimed to evaluate placental α‐macroglobulin‐1 as a new diagnostic marker in the prediction of preterm birth. Material and methods We performed a prospective observational trial in women with intact membranes between 24+0 and 36+6 weeks of gestation. We included both women with and without threatened preterm labor symptoms. We evaluated the test performance of placental α‐macroglobulin‐1 measurements in cervicovaginal fluid regarding three different presentation‐to‐delivery intervals: ≤2, ≤7, ≤14 days. In addition, we calculated placental α‐macroglobulin‐1 performance in combination with other prognostic factors such as ultrasonographic cervical length measurements. Results We included 126 women in the study. We detected high specificity (97%‐98%) and negative predictive value (89%‐97%) for placental α‐macroglobulin‐1 at all time intervals. We assessed placental α‐macroglobulin‐1 in combination with cervical length measurements (≤15 mm) in the sub‐group of women presenting with threatened preterm labor symptoms (n = 63) and detected high positive predictive values (100%) for 7‐ and 14‐day presentation‐to‐delivery intervals. Conclusions Our study provides evidence that placental α‐macroglobulin‐1 testing in cervicovaginal fluid, in combination with cervical length measurements, accurately predicts preterm birth in women with preterm labor symptoms. This novel test combination may be used clinically to triage women presenting with threatened preterm labor, avoiding overtreatment and unnecessary hospitalizations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cervico‐vaginal placental α‐macroglobulin‐1 combined with cervical length for the prediction of preterm birth in women with threatened preterm labor

Radan

Polowy

Heverhagen

et al. 2019

Acta Obstet Gynecol Scand

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“…Nikolova et al [26], concluded that the PAMG-1 (placental alpha microglobulin-1) is better predictor of imminent PTL when compared with phosphorylated-IGFBP-1 (ph IGFBP-1) alone or in combination with CL.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of PremaQuick in detection of preterm labor in symptomatic women

Abdelazim

Karimova²,

Shikanova

2022

Ginekol Pol

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Objectives: Failure to identify women at risk of preterm labor (PTL) leads to failure to implement standard measures. This study designed to evaluate the accuracy of PremaQuick test in detection of PTL in women presented with threatened preterm labor (TPTL). Material and methods:One hundred and twenty-two (122) pregnant women, singleton pregnancy, < 37 weeks, admitted with TPTL included in this study, and were compared to 122 controls.After thorough evaluation, participants were examined using sterile vaginal speculum for cervico-vaginal fluid (CVF) sampling, and PremaQuick test. The CVF sampling was followed by trans-vaginal sonographic (TVS) assessment of cervical length (CL). Participants were managed according to hospitals policy thorough their admission, and after discharge in the ante-natal clinics till delivery. After delivery, the delivery data were compared by the recorded participants` data on admission. Results:The PremaQuick test had 95.1% sensitivity, 97.5% specificity, 97.5% positive predictive value, 95.2% negative predictive value, and 96.3% accuracy in detection of PTL.The PremaQuick had significantly higher true negative rate, specificity, positive predictive 2 value, and overall accuracy in detection of PTL compared to CL < 25 mm (p = 0.005, 0.005, 0.01, 0.002; respectively). Conclusions:The PremaQuick is an accurate bedside test in detection of PTL in women presented with TPTL. It had 95.1% sensitivity, 97.5% specificity, 97.5% positive predictive value, 95.2% negative predictive value, and 96.3% overall accuracy in detection of PTL. The PremaQuick had significantly higher true negative rate, specificity, positive predictive value, and overall accuracy in detection of PTL compared to CL < 25 mm.

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“…However, another study conducted by Sun et al [ 7 ] showed that cervical length of about 25 mm was the cutoff threshold value for the risk of preterm birth. Accordingly, Nikolova et al [ 8 ] suggested it is necessary to track changes to the cervix between 24 and 28 wk of pregnancy to detect abnormal status in women.…”

Section: Discussionmentioning

confidence: 99%

Significance of highly phosphorylated insulin-like growth factor binding protein-1 and cervical length for prediction of preterm delivery in twin pregnancies

Lan¹,

Song²,

Gong³

et al. 2021

WJCC

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BACKGROUND A twin pregnancy can carry greater risks than singleton pregnancies. About 60 in 100 twin pregnancies result in spontaneous birth before 37 wk, which is associated with several complications in the premature babies. Clinical detection of biomarkers may help to predict the possibility of premature birth so that corresponding interventions can be given to the pregnant women in a timely manner, in order to reduce the risk of preterm birth and improve the outcomes of the newborn infants. AIM To explore the clinical value of transvaginal ultrasound measurement of cervical length combined with insulin-like growth factor binding protein-1 (IGFBP-1) hyperphosphorylation in cervical secretions as predictors of preterm delivery in twin pregnancies. METHODS A total of 254 pregnant women with twin pregnancies, who were admitted to Hainan General Hospital and underwent maternity examination, were selected as the study subjects from January 2015 to December 2018. All participants received transvaginal ultrasound measurement of cervical length and phosphorylated IGFBP-1 (phIGFBP-1) test between 24 and 34 wk gestation. The pregnancy outcomes were analyzed. RESULTS Of the women with a positive phIGFBP-1 test result, preterm birth rate was higher in those with a cervical length ≤ 25 mm than those with a cervical length > 25 mm (all P < 0.05). Similarly, in women with a negative phIGFBP-1 test result, preterm birth rate was higher in those with a cervical length ≤ 25 mm than those with a cervical length > 25 mm (all P < 0.05). The sensitivity, specificity, and positive and negative predictive values of the phIGFBP-1 test combined with the cervical length test were 95.71%, 91.21%, 95.12% and 92.22%, respectively, for the prediction of preterm birth. CONCLUSION Cervical length combined with phIGFBP-1 tests is of value for the prediction of outcomes of preterm delivery in twin pregnancies.

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Prediction of spontaneous preterm delivery in women presenting with premature labor: a comparison of placenta alpha microglobulin-1, phosphorylated insulin-like growth factor binding protein-1, and cervical length

Cited by 33 publications

References 41 publications

Cervico‐vaginal placental α‐macroglobulin‐1 combined with cervical length for the prediction of preterm birth in women with threatened preterm labor

Cervico‐vaginal placental α‐macroglobulin‐1 combined with cervical length for the prediction of preterm birth in women with threatened preterm labor

Diagnostic accuracy of PremaQuick in detection of preterm labor in symptomatic women

Significance of highly phosphorylated insulin-like growth factor binding protein-1 and cervical length for prediction of preterm delivery in twin pregnancies

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