Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels

Tanbo, Tom; Dale, Per Olav; Lunde, O. C.; Norman, Nils; Åbyholm, Thomas

doi:10.1016/s0015-0282(16)54965-6

Cited by 93 publications

(44 citation statements)

References 20 publications

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“…Our data are in concordance with earlier studies reporting CCCT as being more sensitive than day 3 FSH alone in predicting both cycle cancellation and pregnancy rates (2,28,29). In one study, approximately twice as many patients were identified by using CCCT as compared to basal FSH screening alone and the cancellation rate was found to be higher in women with abnormal test results (29). Loumaye et al evaluated CCCT by defining a threshold value of 26 IU/L as the sum of cycle day 3 and 10 FSH values and concluded that predictive value of an abnormal test for failing to conceive was 100% (28).…”

Section: Discussionsupporting

confidence: 93%

“…increased to 40.6% when CCCT was performed which indicated that a significant number of patients with restricted ovarian reserve would have been missed if the challenge test was not applied. Our data are in concordance with earlier studies reporting CCCT as being more sensitive than day 3 FSH alone in predicting both cycle cancellation and pregnancy rates (2,28,29). In one study, approximately twice as many patients were identified by using CCCT as compared to basal FSH screening alone and the cancellation rate was found to be higher in women with abnormal test results (29).…”

Section: Discussionsupporting

confidence: 91%

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Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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“…Various tests to screen ovarian reserve have been described so far. The best-documented test is the Clomiphene Challenge Test (CCT) suggested by Navot et al [9] and described by other authors [10][11][12][13][14][15] . In this test, basal FSH on day 3 is compared with the FSH response on day 9 after oral clomiphene citrate administration from days 5 to 9.…”

Section: Introductionmentioning

confidence: 99%

Obesity and Clomiphene Challenge Test as Predictors of Outcome of in vitro Fertilization and Intracytoplasmic Sperm Injection

Swieten¹,

Leeuw-Harmsen²,

Badings³

et al. 2005

Gynecol Obstet Invest

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One hundred and sixty-two consecutive patients undergoing in vitro fertilization (IVF) or IVF/intracytoplasmic sperm injection (ICSI) were studied to determine the effect of obesity on the outcome of this treatment and to evaluate the prognostic value of the Clomiphene Challenge Test (CCT) in controlled ovarian hyperstimulation. In this prospective clinical study, we assessed the mean number of stimulation days, the mean gonadotropin level/day, cancellation rate, the mean thickness of the endometrium, the mean number of oocytes retrieved, the fertilization rate, the clinical pregnancy rate/embryo transfer and the abortion rate. Obese women had a doubled risk of cancellation due to poor response, although this was not statistically significant. Furthermore, they showed up to 45% lower fertilization rates compared to women of normal weight. The CCT was a good predictor of IVF and IVF/ICSI outcome. Women with an abnormal CCT needed more days of stimulation and higher doses of gonadotropins to reach an adequate stimulation, but still overall results were less than in women with a normal CCT. We conclude that obesity negatively affects IVF and IVF/ICSI outcome, and that CCT is a useful prognosticator of response to ovarian stimulation. Obese patients show a tendency to experience more cancellation due to poor response and lower fertilization rates. Obese women should be counseled on their possible poor performance in IVF and IVF/ICSI programs.

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“…[17][18][19] These studies evaluated stimulated FSH concentrations only. Because the use of CC stimulates the growth of follicles, we postulated that basal ovarian stromal blood flow would be increased as well after CCCT.…”

Section: Discussionmentioning

confidence: 99%

Ovarian stromal blood flow following clomiphene citrate challenge test in infertile women

Tang

Chan

et al. 2008

J of Clinical Ultrasound

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Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels

Cited by 93 publications

References 20 publications

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Obesity and Clomiphene Challenge Test as Predictors of Outcome of in vitro Fertilization and Intracytoplasmic Sperm Injection

Ovarian stromal blood flow following clomiphene citrate challenge test in infertile women

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