Prediction of recurrent glioblastoma after laser interstitial thermal therapy: The role of diffusion imaging

Mahammedi, Abdelkader; Bachir, Suha; Escott, Edward J.; Barnett, Gene H.; Mohammadi, Alireza; Larvie, Mykol

doi:10.1093/noajnl/vdz021

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…This would be disadvantageous as the ADC maps have also shown promising results with regard to identifying infiltrative patterns of glioma growth [32], predicting O 6 -methylguanine-DNA methyl-transferase (MGMT) methylation status [33] and predicting treatment outcomes and survival [33][34][35]. In addition, in patients who underwent laser interstitial thermal therapy for glioblastoma, the ADC value of the direct postoperative MRI scan (< 24 h) in the peritumoral region showed to be correlated with regions of later tumor recurrence [36].…”

Section: Discussionmentioning

confidence: 99%

Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis

Elshout

Scheenen

Driessen³

et al. 2022

Insights Imaging

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Background In a considerable subgroup of glioma patients treated with (chemo) radiation new lesions develop either representing tumor progression (TP) or treatment-related abnormalities (TRA). Quantitative diffusion imaging metrics such as the Apparent Diffusion Coefficient (ADC) and Fractional Anisotropy (FA) have been reported as potential metrics to noninvasively differentiate between these two phenomena. Variability in performance scores of these metrics and absence of a critical overview of the literature contribute to the lack of clinical implementation. This meta-analysis therefore critically reviewed the literature and meta-analyzed the performance scores. Methods Systematic searching was carried out in PubMed, EMBASE and The Cochrane Library. Using predefined criteria, papers were reviewed. Diagnostic accuracy values of suitable papers were meta-analyzed quantitatively. Results Of 1252 identified papers, 10 ADC papers, totaling 414 patients, and 4 FA papers, with 154 patients were eligible for meta-analysis. Mean ADC values of the patients in the TP/TRA groups were 1.13 × 10−3mm2/s (95% CI 0.912 × 10–3–1.32 × 10−3mm2/s) and 1.38 × 10−3mm2/s (95% CI 1.33 × 10–3–1.45 × 10−3mm2/s, respectively. Mean FA values of TP/TRA was 0.19 (95% CI 0.189–0.194) and 0.14 (95% CI 0.137–0.143) respectively. A significant mean difference between ADC and FA values in TP versus TRA was observed (p = 0.005). Conclusions Quantitative ADC and FA values could be useful for distinguishing TP from TRA on a meta-level. Further studies using serial imaging of individual patients are warranted to determine the role of diffusion imaging in glioma patients.

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Section: Discussionmentioning

confidence: 99%

Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis

Elshout

Scheenen

Driessen³

et al. 2022

Insights Imaging

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“…One active area of prognostication research is the use of imaging for prediction of GBM recurrence after LITT. Recent analysis of postablation diffusion-weight imaging (DWI) sequences suggests that DWI may be able to predict specific locations for GBM recurrence [58]. The authors performed a retrospective review of 39 patients with GBM that had undergone LITT and postoperative MRI approximately 24 hours after ablation at a single institution.…”

Section: Developing Prognostication Tools In Litt For Gbmmentioning

confidence: 99%

Minimally Invasive Treatments for Glioblastoma: A Review of Current and Emerging Surgical Technologies

Mezzacappa¹,

Davidson²,

Aizenberg³

2023

OBM Neurobiol

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Glioblastoma (GBM) is malignant, primary intracranial neoplasm associated with poor outcomes. Maximal, safe cytoreduction remains an important component of effective treatment for patients with this disease; however, some patients are not candidates for resection due to comorbid status, tumor location, or other factors. In this review, we aimed to describe minimally invasive surgical techniques that are emerging as important tools for improving safety and efficiency in GBM cytoreduction, including for patients with previously unresectable lesions. Specifically, we aimed to describe the commercially available tubular retractor systems and describe the available data regarding the benefits, risks, and utility of these retractors for patients with GBM. Additionally, we aimed to describe laser interstitial thermal therapy (LITT) and its use in GBM, including a description of the mechanism of action, commercially available systems, the steps in surgical implantation, available outcomes data, and future directions for the technology in this context. Finally, we aimed to review the use of MRI-guided high-intensity focused ultrasound (MRgHIFU) in GBM, including a description of its mechanism and data regarding efficacy in GBM. The availability and use of tubular retractors, LITT, and MRgHIFU provide clinically effective alternative methods for cytoreduction in GBM and are also emerging as important tools for the expansion of treatment to GBM that previously may have been classified as nonresectable. This review will assist in the development of an intimate knowledge of the use and utility of these techniques and is important for clinicians caring for patients with GBM.

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“…Mohammadi et al suggested that areas of DWI signal decrease and an increase in apparent diffusion coefficient along the peritumoral areas in the 24 h post-LITT MRI could harbor residual tumor. These findings could potentially be used to identify areas of future progression and recurrence [29].…”

Section: Special Imaging Modalities In Littmentioning

confidence: 99%

Laser thermal therapy in the management of high-grade gliomas

Avecillas-Chasín

Atik

Mohammadi

et al. 2020

International Journal of Hyperthermia

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Laser interstitial thermal therapy (LITT) is a minimally invasive therapy that have been used for brain tumors, epilepsy, chronic pain, and other spine pathologies. This therapy is performed under imaging and stereotactic guidance to precisely direct the probe and ablate the area of interest using real-time magnetic resonance (MR) thermography. LITT has gained popularity as a treatment for glioma because of its minimally invasive nature, small skin incision, repeatability, shorter hospital stay, and the possibility of receiving adjuvant therapy shortly after surgery instead of several weeks as required after open surgical resection. Several reports have demonstrated the usefulness of LITT in the treatment of newly-diagnosed and recurrent gliomas. In this review, we will summarize the recent evidence of this therapy in the field of glioma surgery and the future perspectives of the use of LITT combined with other treatment strategies for this devastating disease.

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Prediction of recurrent glioblastoma after laser interstitial thermal therapy: The role of diffusion imaging

Cited by 5 publications

References 37 publications

Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis

Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis

Minimally Invasive Treatments for Glioblastoma: A Review of Current and Emerging Surgical Technologies

Laser thermal therapy in the management of high-grade gliomas

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