Prediction of rapid bone loss in postmenopausal women

Christiansen, C; Riis, B.J.; Rødbro, P.

doi:10.1016/0378-5122(87)90018-1

Cited by 52 publications

(71 citation statements)

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“…This increase is maintained for several decades after the menopause [30] and is associated with accelerated bone loss [31][32][33][34][35][36][37][38][39]. An increased rate of bone loss from the forearm and hip is associated with an increase in the risk of vertebral fracture [40,41], an effect independent of final BMD.…”

Section: Rationalementioning

confidence: 97%

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards

et al. 2010

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Section: Rationalementioning

confidence: 97%

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards

et al. 2010

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“…Far less is known about the use of markers to assess balance between resorption and formation. A few simple balance indexes have been explored but these have for the most part been empiric in nature and have not been found to be more informative than either resorption or formation markers alone [119]. More sophisticated mathematical models for a balance index should be explored and evaluated clinically.…”

Section: Summary and Future Research Directionsmentioning

confidence: 99%

Clinical Use of Biochemical Markers of Bone Remodeling: Current Status and Future Directions

Looker

Bauer

Chesnut

et al. 2000

Osteoporosis International

223

117

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Biochemical markers of bone turnover provide a means of evaluating skeletal dynamics that complements static measurements of bone mineral density (BMD). This review evaluates the use of commercially available bone turnover markers as aids in diagnosis and monitoring response to treatment in patients with osteoporosis. High within-person variability complicates but does not preclude their use. Elevated bone resorption markers appear to be associated with increased fracture risk in elderly women, but there is less evidence of a relationship between bone formation markers and fracture risk. The critical question of predicting fracture efficacy with treatment has not been answered. Changes in bone markers as currently determined do not predict BMD response to either bisphosphonates or hormone replacement therapy. Single measurements of markers do not predict BMD cross-sectionally (except possibly in the very elderly), or change in BMD in individual patients, either treated or untreated. On the other hand, research applications of bone turnover markers are of value in investigating the pathogenesis and treatment of bone diseases. Markers have potential in the clinical management of osteoporosis, but their use in this regard is not established. Additional studies with fracture endpoints and information on negative and positive predictive value are needed to evaluate fully the utility of bone turnover markers in individual patients.

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“…In 1979, 178 women completed a 2-year, prospective study receiving placebo [13,14]. They had been selected by questionnaire and a medical screening examination.…”

Section: Subjectsmentioning

confidence: 99%

Potential risk factors for development of postmenopausal osteoporosis — Examined over a 12-year period

et al. 1991

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In a longitudinal study, we investigated the influence of risk factors on bone mass at menopause and postmenopausal bone loss in 121 healthy postmenopausal women. These women had completed a 2-year prospective study in 1979 and a follow-up examination in 1989. Measurements of the bone mineral content in the distal forearm (single photon absorptiometry) were performed 9 times during the initial study and once at the follow-up examination. Bone mass at menopause (initial measurement), rate of early postmenopausal bone loss, and the subsequent rate of bone loss over 10 years were thus determined. In addition, the bone mineral density of the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry (DXA) in 1989. Information about risk factors was assessed by standardized questionnaires and included reproductive history and lifestyle factors (intake of calcium and vitamin D supplements, consumption of alcohol and caffeine, smoking habits, and physical activity). Lactation, oral contraceptive use, and dietary calcium intake above 1500 mg per day was associated with significantly increased bone mass at menopause. The number of pregnancies reduced the rate of early postmenopausal bone loss, whereas moderate alcohol consumption reduced the subsequent rate of bone loss. Smoking significantly reduced femoral bone mineral density. In conclusion, the present prospective study showed that some of the examined putative risk factors positively influenced bone mass at menopause, especially calcium intake, whereas the postmenopausal bone loss was virtually unaffected. Assessment of risk factors in postmenopausal women thus seems to have limited value for reducing future risk of osteoporosis.

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Prediction of rapid bone loss in postmenopausal women

Cited by 52 publications

References 0 publications

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards

Clinical Use of Biochemical Markers of Bone Remodeling: Current Status and Future Directions

Potential risk factors for development of postmenopausal osteoporosis — Examined over a 12-year period

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