Prediction of Psychosis in Adolescents and Young Adults at High Risk

Ruhrmann, Stephan; Schultze‐Lutter, Frauke; Salokangas, Raimo K. R.; Heinimaa, Markus; Linszen, Don; Dingemans, Peter; Birchwood, Max; Patterson, Paul; Juckel, Georg; Heinz, Andreas; Morrison, Anthony P.; Lewis, Shôn; Reventlow, H. Graf von; Klosterkötter, Joachim

doi:10.1001/archgenpsychiatry.2009.206

Cited by 569 publications

(222 citation statements)

References 72 publications

(117 reference statements)

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“…However, evidence is still lacking for other neuroimaging features. Several authors have now suggested to aim for a two steps approach in the management of at-risk patients by adding a classification step after their clinical identification (Koutsouleris et al 2012;Ruhrmann et al 2010). The proposed classifications may use clinical, cognitive, environmental and neuroimaging features alone or in combination (Shah et al 2012).…”

Section: Identification Of Patients With Psychotic Symptoms Within Thmentioning

confidence: 99%

Identifying 22q11.2 Deletion Syndrome and Psychosis Using Resting-State Connectivity Patterns

et al. 2014

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The clinical picture associated with 22q11.2 deletion syndrome (22q11DS) includes mild mental retardation and an increased risk of schizophrenia. While the clinical phenotype has been related to structural brain network alterations, there is only scarce information about functional connectivity in 22q11DS. However, such studies could lead to a better comprehension of the disease and reveal potential biomarkers for psychosis. A connectivity decoding approach was used to discriminate between 42 patients with 22q11DS and 41 controls using resting-state connectivity. The same method was then applied within the 22q11DS group to identify brain connectivity patterns specifically related to the presence of psychotic symptoms. An accuracy of 84 % was achieved in differentiating patients with 22q11DS from controls. The discriminative connections were widespread, but predominantly located in the bilateral frontal and right temporal lobes, and were significantly correlated to IQ. An 88 % accuracy was obtained for identification of existing psychotic symptoms within the patients group. The regions containing most discriminative connections included the anterior cingulate cortex (ACC), the left superior temporal and the right inferior frontal gyri. Functional connectivity alterations in 22q11DS affect mostly frontal and right temporal lobes and are related to the syndrome's mild mental retardation. These results also provide evidence that resting-state connectivity can potentially become a biomarker for psychosis and that ACC plays an important role in the development of psychotic symptoms.

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Section: Identification Of Patients With Psychotic Symptoms Within Thmentioning

confidence: 99%

Identifying 22q11.2 Deletion Syndrome and Psychosis Using Resting-State Connectivity Patterns

et al. 2014

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“…1c; table 1), as longitudinal studies had indicated that a decline in functioning indicates a higher risk of transition to psychosis [17,18]. …”

Section: Uhr and Related Criteria And Their Operationalizationmentioning

confidence: 99%

“…1a), was made in the European Prediction of Psychosis Study (EPOS) [18]. Therein, APS and BLIPS were alternatively assessed by the SIPS positive items as well as by the ‘odd behavior or appearance’ (SIPS-D1) item but not by the other 3 disorganized items (tables 1, 2).…”

Section: Other Uhr-related At-risk Approachesmentioning

confidence: 99%

‘A Rose Is a Rose Is a Rose’, but At-Risk Criteria Differ

et al. 2012

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Background: Over the last 15 years, efforts to detect psychoses early in their prodromal states have greatly progressed; meanwhile, ultra-high risk (UHR) criteria have been the subject of such consensus that parts of them have been proposed for inclusion in DSM-5 in terms of an attenuated psychosis syndrome. However, it is frequently unacknowledged that the definitions and operationalizations of UHR-related at-risk criteria, including the relevant attenuated psychotic symptoms, vary considerably across centers and time and, thus, between prediction studies. Methods: These variations in UHR criteria are described and discussed with reference to the rates of transition to psychosis, their prevalence in the general population and the proposed new operationalization of the attenuated psychosis syndrome. Results: A comparison of samples recruited according to different UHR operationalizations reveals differences in the distribution of UHR criteria and transition rates as well as in the prevalence rates of at-risk criteria in the general population. Conclusion: The evidence base for the introduction of such a new syndrome is weaker than the number of studies using supposedly equal UHR criteria would at first suggest. Thus, studies comparing the effects of different (sub-)criteria not only on transition rates and outcomes but also on other important aspects, such as neurocognitive performance and brain imaging results, are necessary. Meanwhile, the preliminary attenuated psychosis syndrome in DSM-5 should not follow an altogether new definition but, rather, the currently most reliable UHR definition, which must still demonstrate its reliability and validity outside specialized psychiatric services.

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“…С одной стороны, сочетание таких симптомов с тремя другими критериями «ультравысокого риска» суще-ственно повышает риск манифестации заболевания [15], а с другой, проведенные скрининговые исследования попу-ляции здоровых подростков показали, что отдельные из этих симптомов могут встречаться у каждого 10-го [16]. В связи с этим даже было предложено относить эти сим-птомы к возрастной норме.…”

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“…По данным ряда авторов [15,19,[20][21][22][23], манифестация психоза в группе ультравысо-кого риска составляет в течение 6 мес 18% (12-25%), 1 года -22% (17-28%), 2 лет -29% (23-36%), 3 лет -32% (24-35%), более 3 лет (3 года -5 лет) -36% (30-43%). Было проведено несколько работ [24,25], касающихся ка-тамнеза пациентов из группы риска, у которых эндоген-ный психоз не манифестировал.…”

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The dynamics of psychopathological symptoms of ultra high risk for psychosis in young patients with non-psychotic mental disorders

Омельченко

Rumyantsev

Каледа

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Одна из актуальных задач современной психиатрии -первичная профилактика заболеваний шизофреническо-го спектра, цель которой состоит в установлении и попыт-ке минимизации факторов этиологического риска, но и разработке системы мер предупреждения развития эндо-генного процесса. Проводятся исследования по поиску клинических [1, 2] и биологических [3-5] маркеров ши-зофрении на доманифестном этапе. Предпринимаются попытки проспективного выявления патогномоничных для шизофрении аномалий личности [6,7] и ретроспек-тивного установления их корреляций с психопатологиче-© Коллектив авторов, 2016

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Prediction of Psychosis in Adolescents and Young Adults at High Risk

Cited by 569 publications

References 72 publications

Identifying 22q11.2 Deletion Syndrome and Psychosis Using Resting-State Connectivity Patterns

Identifying 22q11.2 Deletion Syndrome and Psychosis Using Resting-State Connectivity Patterns

‘A Rose Is a Rose Is a Rose’, but At-Risk Criteria Differ

The dynamics of psychopathological symptoms of ultra high risk for psychosis in young patients with non-psychotic mental disorders

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