Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI

Bloch, B; Genega, Elizabeth M.; Costa, Daniel N.; Pedrosa, Iván; Smith, Martin P.; Kressel, Herbert Y.; Ngo, Long; Sanda, Martin G.; DeWolf, William C.; Rofsky, Neil M.

doi:10.1007/s00330-012-2475-5

Cited by 79 publications

(42 citation statements)

References 63 publications

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“…[14][15][16][17] MpMRI interpretation is based on Prostate Imaging and Reporting Archiving Data System version 2 (PI-RADS v2) [18] , introduced to improve standardization of MRI interpretation by reporting suspicion scores (1-to 5-point scale based on fixed criteria) to provide clinical management guideline for suspicious PCa.…”

Section: Introductionmentioning

confidence: 99%

Biparametric MRI of the prostate

Scialpi

D’Andrea

Martorana

et al. 2017

Turkish Journal of Urology

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Biparametric Magnetic Resonance Imaging (bpMRI) of the prostate combining both morphologic T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) is emerging as an alternative to multiparametric MRI (mpMRI) to detect, to localize and to guide prostatic targeted biopsy in patients with suspicious prostate cancer (PCa). BpMRI overcomes some limitations of mpMRI such as the costs, the time required to perform the study, the use of gadolinium-based contrast agents and the lack of a guidance for management of score 3 lesions equivocal for significant PCa. In our experience the optimal and similar clinical results of the bpMRI in comparison to mpMRI are essentially related to the DWI that we consider the dominant sequence for detection suspicious PCa both in transition and in peripheral zone. In clinical practice, the adoption of bpMRI standardized scoring system, indicating the likelihood to diagnose a clinically significant PCa and establishing the management of each suspicious category (from 1 to 4), could represent the rationale to simplify and to improve the current interpretation of mpMRI based on Prostate Imaging and Reporting Archiving Data System version 2 (PI-RADS v2). In this review article we report and describe the current knowledge about bpMRI in the detection of suspicious PCa and a simplified PI-RADS based on bpMRI for management of each suspicious PCa categories to facilitate the communication between radiologists and urologists.

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Section: Introductionmentioning

confidence: 99%

Biparametric MRI of the prostate

Scialpi

D’Andrea

Martorana

et al. 2017

Turkish Journal of Urology

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“…Our findings suggest that the negative predictive value for ECE with 1.5T MRI is inadequate to safely triage patients for nerve-sparing radical prostatectomy, as a large percentage of these patients may in reality have extra-capsular disease. It is important to note that since our data extraction period, we have transitioned to the use of 3T MRI, which we anticipate will increase the diagnostic accuracy of MRI for ECE and SVI as has been previously shown [12] . The next phase of our study will include collection of data for patients who underwent 3T prostate MRI to determine whether this change alone results in any differences in the predictive value of MRI in the evaluation of T3 prostate cancer.…”

Section: Discussionmentioning

confidence: 96%

“…The utilization of different MRI imaging techniques may have contributed to the wide variability in reporting the sensitivity, specificity, and predictive values of MRI for staging purposes [10] . The ability of MRI to detect ECE has been reported with sensitivities ranging between 23 to 91% and specificities ranging between 84 to 97% [11][12][13] . One study reported a positive predictive value of 79% and a negative predictive value of 91% for ECE with 3T MRI with ER coil [12] .…”

Section: Introductionmentioning

confidence: 99%

“…The ability of MRI to detect ECE has been reported with sensitivities ranging between 23 to 91% and specificities ranging between 84 to 97% [11][12][13] . One study reported a positive predictive value of 79% and a negative predictive value of 91% for ECE with 3T MRI with ER coil [12] . Similar studies have been performed to evaluate MRI for the detection of SVI, reporting sensitivities ranging between 25 to 100% and specificities of 62 to 99%.…”

Section: Introductionmentioning

confidence: 99%

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Prostate MRI to Evaluate Extra-Prostatic Disease: A Single Center Analysis

Bishop¹,

Layton²,

Mega³

et al. 2015

IJCO

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Introduction: To examine the use of prostate magnetic resonance imaging (MRI) for staging after a new diagnosis of prostate cancer in our hospital system. There are no universally accepted recommendations to guide the use of MRI for staging purposes. In practice, prostate MRI is used to help distinguish T2 and T3 cancer. Prostate MRI is a modality that could aid in the triage of patients to radical prostatectomy or non-surgical treatments via accurate identification of organ-confined disease. Materials and Methods:We performed a retrospective review of prostate cancer patients who underwent staging MRI with 1.5T MRI with endorectal (ER) coil. We compared patient characteristics in patients who underwent surgery and those who did not, and used pathology reports from prostatectomy samples to calculate the negative predictive value (NPV) for extra-capsular extension (ECE) and seminal vesicle invasion (SVI). Results: We found that patients who underwent radical prostatectomy were younger, had lower Gleason scores, and had lower PSA values at diagnosis than patients who were not treated surgically. We calculated a NPV of 93.7% for SVI and 69.5% for ECE. We found variation in rates of accurate identification of T3 prostate cancer across the seven radiologists who interpreted MRI images in our study. Conclusions: 1.5T MRI with ER coil has a high NPV for SVI and a lower NPV for ECE. The utilization of 3TMRI may enable practitioners to more confidently rule out ECE. Future studies will be necessary to generate guidelines for use of MRI in prostate cancer staging.

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“…[11] MRI has been utilized to diagnose and stage PC. [11][12][13] reported a 13%-95% sensitivity and a 49%-97% specificity for MRI in the detection of extracapsular extension (ECE). [9] Developments in MRI technology improved tumor localization and detection of ECE.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of the efficacy of magnetic resonance spectroscopy imaging for predicting locally advanced prostate cancer

Razi

Parizi

Kazemeini

et al. 2015

Turkish Journal of Urology

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Objective: To evaluate the efficacy of magnetic resonance spectroscopy imaging (MRSI) for predicting locally advanced prostate cancer (PC). Material and methods:Between April 2009 and July 2012, 80 consecutive patients with clinically localized PC had undergone endorectal MRSI before radical retropubic prostatectomy. Clinicopathological parameters, including age, preoperative prostate-specific antigen (PSA), Gleason score (GS) at biopsy, perinural invasion at biopsy, prostate weight at surgery, GS of surgical specimen, and pathological staging were recorded. The MRSI findings were compared with the histopathological findings of the radical prostatectomy. The diagnostic accuracy measures consisting of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of MRSI, and other variables in the diagnosis of locally advanced PC (Pathology Stages pT3a, pT3b, or pT4) were evaluated.Results: Sensitivity, specificity, PPV, and NPV of MRSI in detecting locally advanced PC is 42.4%, 93.6%, 82.3%, and 69.8%, respectively [area under the receiver operating characteristic (ROC) curve= 0.658, p value <0.0001]. MRSI, cancer-positive core percentage at biopsy, and GS at biopsy are more accurate factors among all the predictive variables in predicting locally advanced PC. Conclusion:MRSI may be considered as a complementary diagnostic modality with high specificity and moderate sensitivity in predicting locally advanced PC. Combination of this modality with other predictive factors helps the surgeon and patient to select an appropriate treatment strategy.

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Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI

Cited by 79 publications

References 63 publications

Biparametric MRI of the prostate

Biparametric MRI of the prostate

Prostate MRI to Evaluate Extra-Prostatic Disease: A Single Center Analysis

A prospective study of the efficacy of magnetic resonance spectroscopy imaging for predicting locally advanced prostate cancer

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