Prediction of preterm delivery by combined use of simple clinical tests

Arinami, Yoshinari; Hasegawa, Isao; Takakuwa, Koichi; Tanaka, Kenichi

doi:10.1002/(sici)1520-6661(199903/04)8:2<70::aid-mfm8>3.3.co;2-c

Cited by 4 publications

(8 citation statements)

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“…After removal of duplicates, 516 studies were identified and screened for their eligibility. Ninety full‐text papers were reviewed and 15 studies were subsequently included (Figure ) . The inter‐rater reliability for the study selection was good (κ = 0.8).…”

Section: Resultsmentioning

confidence: 99%

“…There was variation in the devices used by studies included in this review for measuring fFN. Seven studies used Adeza Biomedical, Sunnyvale ® , , five studies used Hologic ® and three studies did not provide information regarding the device used. Ten studies collected samples for fFN testing according to the manufacturer's instructions (“standard” fFN).…”

Section: Resultsmentioning

confidence: 99%

“…In singleton pregnancy studies, six used serial sampling (timing not specified in one study ; every two, two to three, two to four or every two to six weeks in the five remaining studies with samples collected between 22 and 36 weeks of gestation. Three studies used a single sample of fFN taken at 22–28, 26–28 or 28 weeks of gestation . For the twin studies, fFN testing was performed every two to four weeks between 22 and 32 weeks of gestation in all three included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Ten of studies used the last menstrual period to calculate the gestational age, which was confirmed by a first or second trimester ultrasound. The ultrasound result took precedence if there was a discrepancy . Five studies did not specify how the gestational age was calculated .…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies reported accuracy data for fFN in singleton pregnancies of which six (1236 women) included women without risk factors for PTB (Figure ). The pooled sensitivity and the specificity were 0.48 (95% CI 0.20–0.77) and 0.96 (95% CI 0.86–0.99) (Figure ).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Santos

Daru

Rogozińska

et al. 2018

Acta Obstet Gynecol Scand

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Santos

Daru

Rogozińska

et al. 2018

Acta Obstet Gynecol Scand

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Primary predictors of preterm labour

Goffinet

2005

BJOG

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Spontaneous preterm birth accounts for 60% of all preterm births in developed countries. With the increase in multiple pregnancies, induced preterm birth and the progress in neonatal care for extremely preterm neonates, spontaneous preterm birth for singleton pregnancies in developed countries has probably decreased over the past 30 years. This decrease is likely to be related to better prenatal care for all pregnant women because the recognition of primary risk factors in early or late pregnancy remains a basic part of prenatal care. The failure to distinguish between induced and spontaneous preterm labour in most population-based studies makes it difficult to interpret results with respect to the primary predictors of preterm labour. Many such primary predictors of preterm labour have been used over the past 20 -30 years. These include individual factors, socio-economic factors, working conditions and obstetric and gynaecological history. Risk scores have been proposed in order to produce these data. Unfortunately, the predictive value of these scores, especially their specificity, is poor, mainly because all of these factors are indirect. We still cannot identify the mechanisms that lead to preterm labour and birth. New markers more directly related to preterm labour have recently been proposed, some of which relate to direct causes of preterm labour such as cervical ultrasound measurement, fetal fibronectin (FFN), salivary estriol, serum CRH and bacterial vaginosis. Several of these have predictive values, which are potentially useful for clinical practice. Nonetheless, pregnant women in developed countries are already closely monitored throughout pregnancy. Before proposing new screening tests to be applied systematically to all pregnant women, their advantages and drawbacks must be fully evaluated.

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Randomized trial of ultrasound‐indicated cerclage in singleton women without lower genital tract inflammation

Otsuki

Nakai

Matsuda

et al. 2015

J of Obstet and Gynaecol

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Aim: This is the first report of a randomized trial of cerclage on pure cervical shortening without vaginosis or cervicitis. The objective of our multicenter randomized controlled trial was to assess the benefits of ultrasoundindicated cervical cerclage in the mid-trimester to prevent preterm birth in women who have no signs of infection or inflammation of the lower genital tract. Material and Methods: Women with a short cervical length < 25 mm between 16 and 26 weeks of gestation were randomly assigned to receive a Shirodkar cerclage, McDonald cerclage, or bedrest (no cerclage). Before being randomly assigned to one of the three groups, all women were screened for infection/inflammation of the lower genital tract; those with positive results were excluded from the study. The ratio of preterm delivery as a primary end-point was evaluated in the groups. Results: A total of 106 singleton patients with a short cervical length were assessed for study eligibility; 106 patients were randomized to the three treatment options. Ultimately, 98 patients (in the Shirodkar [n = 34], McDonald [n = 34] and bedrest [n = 30] groups) were analyzed. No differences in preterm delivery or perinatal outcomes were found between the three groups. Significantly fewer patients in the Shirodkar group required hospitalization for treatment of threatened preterm labor when compared to patients in the bedrest group. Conclusion: For women with a short cervical length < 25 mm between 16 and 26 weeks of gestation, Shirodkar cerclage might be considered to reduce the occurrence of threatened preterm labor.

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Prediction of preterm delivery by combined use of simple clinical tests

Cited by 4 publications

References 0 publications

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis

Primary predictors of preterm labour

Randomized trial of ultrasound‐indicated cerclage in singleton women without lower genital tract inflammation

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