Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics

Abstract

Objective:To evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia.Study design:Included were 400 women with singleton deliveries in California in 2009–2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15–20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC).Results:Twenty-five serum biomarkers along with maternal age <34 years and poverty status identified >80% of women with PTB ± preeclampsia with best performance in women with preterm preeclampsia (AUC = 0.889, 95% confidence interval (0.822–0.959) training; 0.883 (0.804–0.963) testing).Conclusion:Together with maternal age and poverty status, mid-pregnancy immune and growth factors reliably identified most women who went on to have a PTB ± preeclampsia.

A systematic review and meta-analysis indicates long-term risk of chronic and end-stage kidney disease after preeclampsia

“…[1][2][3][4][18][19][20][21][22][23] The discussion on whether PE is a single disease, a syndrome, or a spectrum of alterations is still open; the new molecular approaches, and in particular the analysis of the ratio between proangiogenic and anti-angiogenic factors, such as placental growth factor and soluble fms-like tyrosine kinase 1, may offer some interesting insights into its pathogenesis. [1][2][3][4][21][22][23][24][25][26][27][28][29][30] PE is no longer considered as a transitory disease and has been associated with a vast array of cardiovascular and renal diseases, of which the pregnancy-related affection may be a herald, a cause, or a consequence. [31][32][33][34][35][36] Most of the studies and virtually all the systematic reviews show that patients who had PE in $1 pregnancy are at an increased risk of developing cardiovascular and metabolic diseases.…”

The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth

“…Serum samples were drawn between 15 and 20 weeks’ gestation and were not fasted. The population has been described previously (Jelliffe-Pawlowski et al, 2018). Demographic and obstetric factors evaluated included race/ethnicity, maternal age, body mass index, gestational age and gestational age at time of prenatal screening (15–20 weeks gestation).…”

Genetic Risk Scores for Maternal Lipid Levels and Their Association with Preterm Birth

“…Study subjects included a nested case–control sampling of 992 (495 PTB cases and 497 controls) California women with a nonfasted 2nd trimester (15–20 weeks gestation) serum sample banked by the California Biobank Program after it was used for routine prenatal screening. The population has been described previously (Jelliffe‐Pawlowski et al, ). Methods and protocols were approved by the Committee for the Protection of Human Subjects within the Health and Human Services Agency of the State of California (Screening Information System request no.…”