Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report

Cnota, Wojciech; Jagielska, Agnieszka; Janowska, E; Banaś, Ewa; Kierach, Rafał; Nycz-Reska, Malgorzata; Czuba, Bartosz

doi:10.5603/gp.a2021.0171

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…A known and commercially tested protein is placental alpha microglobulin-1 (PAMG-1). Sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of prediction of PTB within seven days were 50%, 80.56%, 12.5% and 96.67%, respectively [25]. Another promising test was the assessment of progesterone gene polymorphism.…”

Section: Discussionmentioning

confidence: 99%

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor

et al. 2024

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Section: Discussionmentioning

confidence: 99%

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor

et al. 2024

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“…However, a number of actions are undertaken to not only implement medical procedures or drugs that reduce the number of preterm births [2], but also to identify a group of patients at high risk of this complication. An important step towards achieving this goal was the introduction of ultrasound cervical length assessment and new biochemical methods [3]. Studies have confirmed that the shorter the cervix, the greater the risk of preterm birth [4] and this relationship is further compounded if there were preterm births in the past and the mother is at an advanced age [5].…”

Section: Introductionmentioning

confidence: 99%

Transabdominal and transvaginal ultrasound assessment of cervical length — can transvaginal approach be avoided?

Korniluk¹,

Kosiński

Dobrowolski

et al. 2023

Ginekol Pol

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“…Серед вагомих причин росту екстрагенітальної захворюваності у вагітних є одна із популярних тенденцій сучасного суспільства -відкладене материнство [22][23][24][25]. Збільшення кількості вагітностей серед жінок віком понад 30-35 років сприяє розвитку ситуацій, коли жінка, яка вступає у вагітність, вже має одне чи кілька екстрагенітальних захворювань [26][27][28].…”

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Placental factors in the development of preterm birth in pregnant women with comorbidity

Heryak

Петренко

Dobrianska

2022

RHW

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Premature birth (PB) is a polyetiological problem that depends on many factors, accompanied by violations of the placenta functional competence, changes in its metabolic, hormone-producing and protective functions. The objective: to establish the importance of placental factors in the development of PB in pregnant women with comorbid pathology. Materials and methods. The levels of fetal and placental proteins (placental alfa microglobulin-1, α2-microglobulin of fertility, trophoblastic β1-glycoprotein) and hormones (estriol, placental lactogen, progesterone) were determined in 33 pregnant women with threat of PB at 26–34 weeks of gestation (main group), who had concomitant comorbid pathology in the stage of unstable remission. The control group included 26 healthy pregnant women who were representative for gestational age. Results. In pregnant women with comorbid pathology a decrease of the placenta protein-synthesizing function and the hormone-producing function of the trophoblast was found, which makes it difficult to launch the syntoxic adaptation programs of the mother’s organism, which are responsible for maintaining the pregnancy with the subsequent development of placental dysfunction, the result of which is PB.The markers of these disorders are a 3-fold decrease in the level of trophoblastic β1-glycoprotein (p<0.0001) and a 1.7-fold decrease in the concentration of α2-microglobulin of fertility (p<0.0001) with a simultaneous 4-fold increase of placental alfa microglobulin-1 concentration (p<0.0001) and a decrease in the levels of placental lactogen by 1.6 times (p<0.0001), estradiol by 40 % (p<0.0001) and progesterone by more than 2 times (p<0.0001) compared to healthy pregnant women.Conclusions. In patients with comorbid pathology there are disorders in the secretion of pregnancy proteins due to a decrease in the levels of trophoblastic β1-glycoprotein and α2-microglobulin of fertility and an increase in the level of placental alfa microglobulin-1 and disorders of the hormone-producing function of the trophoblast due to a decrease in the secretion of placental lactogen, progesterone, and estradiol. The disturbance of the secretion of the pregnancy zone proteins and hormones are the early markers for the initiation of premature birth caused by placental dysfunction in pregnant women with comorbid pathology.

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Prediction of preterm birth using PAMG-1 test: a single centre experience — preliminary report

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 3 publications

References 15 publications

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor

Transabdominal and transvaginal ultrasound assessment of cervical length — can transvaginal approach be avoided?

Placental factors in the development of preterm birth in pregnant women with comorbidity

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