Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis

Guzick, David S.; Silliman, Nancy Paul; Adamson, G. David; Buttram, Veasy C.; Canis, Michel; Malinak, L. Russell; Schenken, Robert S.

doi:10.1016/s0015-0282(97)81392-1

Cited by 166 publications

(75 citation statements)

References 21 publications

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“…Severe endometriosis is associated with pelvic adhesions and a distortion of pelvic anatomy leading to a possible mechanical or anatomical disturbance [6] . Since minimal foci of endometriosis may be associated with marked subfertility [7], even mild stages of the disease may have a direct negative effect on oocyte quality, embryogenesis and implantation [6]. Indeed, patients with endometriosis-associated infertility undergoing IVF respond with significantly decreased levels of markers of reproductive success, resulting in almost one half of the pregnancy rate found among women with other indications for IVF [6].…”

Section: Introductionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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Purpose This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with endometriosis and normozoospermic semen during IVF cycles. Methods Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Rates of fertilization, cleavage, blastulation and embryonic morphology were assessed. Results A total of 786 sibling cumulus-oocyte complexes (COC) were randomized between insemination by conventional IVF (387 COC) or ICSI (399 COC). A significantly higher fertilization rate was found in the ICSI group (ICSI versus IVF, 73.3±23 % versus 54.7±31.9 % respectively; P=0.003), yielding a higher mean number of day 2 embryos (5.2±3.4 versus 3.6±2.9 respectively; P=0.002). Triploid fertilization rate (3PN/COC) was significantly higher in the IVF group compared to the ICSI group (3.9±8.7 % versus 0.9±3.1 % respectively; P=0.02). The morphology score and rate of development of day 2 and 3 embryos were not different between the two groups. Comparison of embryo transfer cycles in which either IVF or ICSI only embryos were transferred did not reveal any statistically significant differences in pregnancy or implantation rates.Conclusion ICSI appears to be a better treatment option than conventional IVF in endometriosis-associated infertility, since it offers the advantages of higher fertilization rate and mean number of embryos and lower rate of total fertilization failure and triploid fertilization.

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Section: Introductionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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“…Recently, Littman et al reported eight IVF pregnancies (five in patients with stage III or IV) in patients with endometriosis after operative laparoscopy who had two failed IVF cycles on average. However, the literature is not conclusive on this issue [28][29][30]. It is worth of note that ICSI is being utilized more frequently in these patients in view of reports of decreased fertilization rate after traditional IVF/ET [29,31,32].…”

Section: Discussionmentioning

confidence: 99%

“…However, the literature is not conclusive on this issue [28][29][30]. It is worth of note that ICSI is being utilized more frequently in these patients in view of reports of decreased fertilization rate after traditional IVF/ET [29,31,32]. Some reports suggested that ICSI can overcome apparent defects in oocytes derived from endometriosis patients [33].…”

Section: Discussionmentioning

confidence: 99%

Unilateral versus bilateral adnexal disease in stage III and stage IV endometriosis does not affect pregnancy outcome after operative laparoscopy

et al. 2008

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To study the effect of unilateral versus bilateral adnexal involvement on the pregnancy rate after operative laparoscopy. Historic cohort study. A total of 143 patients with advanced stages of endometriosis (stage III and IV) who underwent operative laparoscopy for infertility treatment were categorized into those with unilateral versus bilateral adnexal disease. Forty-three patients had primarily unilateral (group 1) and 100 had bilateral disease (group 2). Follow-up was up to 2 years. There was no significant difference between group 1 and group 2 with respect to pregnancy rates (28% vs 31%), delivery rates (21% vs 23%), miscarriage rates (25% vs 13%), and ectopic rates (0% vs 13%). Cumulative conception rates after up to 24 cycles of natural intercourse and up to three IUI cycles were 59% and 49% for group 1 and group 2, respectively. Operative laparoscopy for advanced stages of endometriosis appears to be an effective treatment modality for establishing a pregnancy in infertile patients. Pregnancy and delivery rates are not different in patients with unilateral or bilateral adnexal involvement.

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“…They concluded that impeded hyperperistalsis and dysperistalsis in uterotubal transport associated with endometriosis may be the reason of infertility in these women [4]. Severe endometriosis is also associated with pelvic adhesions and a distortion of pelvic anatomy leading to a possible mechanic or anatomic disturbance of fertility [5,6]. Another factor distorting the pelvic anatomy and thus affecting fertility are large endometriomata seen in patients with extensive endometriosis.…”

Section: Endometriosis and The Alterations In Pelvic Anatomymentioning

confidence: 99%

Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach

Pahlajani

Falcone

2010

Gynecol Surg

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Endometriosis has been one of the most confusing gynecological diseases since it was first described. Whereas there is a reasonable body of evidence in literature to demonstrate an association between endometriosis and infertility, a definite cause and effect relationship has not been established. The mechanism by which endometriosis causes infertility remains an enigma. Virtually every aspect of reproduction in women with endometriosis has been investigated and purported to be impaired. Impairment of implantation and pregnancy rates seems to affect women with endometriosis. Whether this is due to poor quality embryos derived from impaired oocytes or endometrial defects or both has been argued. Structural abnormalities of the uterine wall and tube in women with endometriosis have also been described by other researchers. Adding more confusion to this topic is the altered immune function and the peritoneal environment and their detrimental effects on the sperm motility and morphology. This uncertain pathophysiology has resulted in the lack of consensus on the treatment of endometriosis-associated infertility. The aim of this review is to describe the current pathophysiology of endometriosis-related infertility, how laparoscopic surgery may influence fertility rates.

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Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis

Cited by 166 publications

References 21 publications

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Unilateral versus bilateral adnexal disease in stage III and stage IV endometriosis does not affect pregnancy outcome after operative laparoscopy

Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach

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