Prediction of phase separation behaviour from thermodynamic measurements in the one phase region

Higgins, J. S.; Fruitwala, H.; Tomlins, P E

doi:10.1002/masy.19880160122

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…It has become clear from our observations on several blends that the initial phase size is of order of the molecular dimensions within a factor of two or three, and that the initial stages can be very rapid and may be over in some tens of seconds or less (41)(42)(43). During a short sabbatical visit to the University of California, Santa Barbara, I was persuaded to see if atomic force microscopy (AFM) could detect the phase-separated morphology in spinodal decomposition in real rather than reciprocal space.…”

Section: Phase Separation In Binary Blendsmentioning

confidence: 86%

Neutron Scattering from Polymers: Five Decades of Developing Possibilities

Higgins

2016

Annu. Rev. Chem. Biomol. Eng.

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The first three decades of my research career closely map the development of neutron scattering techniques for the study of molecular behavior. At the same time, the theoretical understanding of organization and motion of polymer molecules, especially in the bulk state, was developing rapidly and providing many predictions crying out for experimental verification. Neutron scattering is an ideal technique for providing the necessary evidence. This autobiographical essay describes the applications by my research group and other collaborators of increasingly sophisticated neutron scattering techniques to observe and understand molecular behavior in polymeric materials. It has been a stimulating and rewarding journey.

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Section: Phase Separation In Binary Blendsmentioning

confidence: 86%

Neutron Scattering from Polymers: Five Decades of Developing Possibilities

Higgins

2016

Annu. Rev. Chem. Biomol. Eng.

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Latest Insights and Methods in Analyzing Liquid Dense Clusters and Crystal Nucleation

Brognaro

Betzel

2018

Encyclopedia of Analytical Chemistry

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Liquid dense clusters (LDCs) are distinct membrane‐less microcompartments of molecules in aqueous solution, which arise in the process of liquid–liquid phase separation. LDC formation is observed most frequently in vivo during cell development, in neurodegenerative diseases and stress signaling, as well as in vitro, in liquid–solid phase transition. LDCs emerge spaciotemporally depending on the physicochemical environment, surface properties, and conformational flexibility of the molecules involved. Knowledge about structural and dynamic properties of growth and division of different macromolecule LDCs and other clustering phenomena, such as gels and fibers, is till now incomplete and only simplified thermodynamic models are available to predict some aspects of clustering so far. For example, for crystal growth a multistep mechanism is today most commonly accepted, starting with the early formation of LDCs, followed by a self‐organization within this LDCs and initial nucleation of an ordered crystal lattice. Therefore, insights about the LDCs formation and stability will also support directed optimization of macromolecule crystallization and will shed light on physiological LDC processes as well. Furthermore, it will support the establishment of new sample preparation and imaging techniques in structural biology utilizing latest and upcoming X‐ray imaging methods at high‐intensity radiation sources.

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Experimental evidence for slow theory of mutual diffusion coefficients in phase separating polymer blends

1989

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Small Angle Neutron Scattering (SANS) is used to study the kinetics of spinodal decomposition of a blend of polymethyl methacrylate (PMMA) with solution chlorinated polyethylene. The early stages of phase separation are quantified using Cahn‐Hilliard theory. Temperature and molecular weight dependences of interdiffusion are studied and it is shown that data can be better interpreted in terms of a wave vector dependent diffusional mobility M(q).

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Prediction of phase separation behaviour from thermodynamic measurements in the one phase region

Cited by 4 publications

References 22 publications

Neutron Scattering from Polymers: Five Decades of Developing Possibilities

Neutron Scattering from Polymers: Five Decades of Developing Possibilities

Latest Insights and Methods in Analyzing Liquid Dense Clusters and Crystal Nucleation

Experimental evidence for slow theory of mutual diffusion coefficients in phase separating polymer blends

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