Prediction of NAFLD occurrence in prediabetes patients

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance and leptinemia in 143 patients registered with prediabetes. Abdominal ultrasound was performed, and fasting insulin, postprandial insulin, leptin levels, common clinical/biochemical determinations were assessed. Certain variables that can predict NAFLD existence were determined and it was found that there is a high prevalence of NAFLD in patients with prediabetes. In univariate analysis, statistically significant associations (P<0.05) were found between waist circumference, systolic blood pressure, diastolic blood pressure, triglycerides, HDL-cholesterol, insulin sensitivity, β-cell function, leptin and NAFLD presence. The coefficients for the variables which obtain statistically significant association (P<0.05) are low, except for leptin which is the biochemical parameter that (in both univariate and multivariate analysis) is a strong predictor of NAFLD presence.

Evaluated Glomerular Filtration Rate Is Associated With Non-alcoholic Fatty Liver Disease: A 5-Year Longitudinal Cohort Study in Chinese Non-obese People

“…We converted the eGFR into a categorical variable according to the quartile and calculated the P for the trend to test the results of the eGFR as the continuous variable and explore the possibility of non-linearity. As the risk of NAFLD was obviously increased in patients with diabetes mellitus ( 7 ), IFG ( 48 ), HTG ( 49 ), CKD ( 28 ), and elevated ALT ( 50 ). Therefore, when exploring the association between eGFR and incident NAFLD in other sensitivity analyses, we excluded participants with FPG > 6.1 mmol/L, TG ≥ 1.7 mmol/L, eGFR < 60 mL/min⋅1.73 m 2 , or ALT > 40 U/L.…”

Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

“…The administration of Sinapine reduced the ratio of Firmicutes to Bacteroidetes and increased the abundance of Lactobacillaceae, Akkermansiaceae , and Blautia . Moreover, Sinapine stimulated G protein-coupled upregulation 43 (GPR43) of short-chain fatty acid (SCFA) in order to suppress the causes of inflammation [ 202 , 203 , 204 ]. A recent research study also found that PPs decreased microbiota dysbiosis by scavenging intestinal reactive oxygen species (ROS) through gut metabolism.…”

Comprehensive Overview of Sleep Disorders in Patients with Chronic Liver Disease

“…Oxidative stress induced by nocturnal intermittent hypoxia is reversible with CPAP therapy, leading to a significant reduction in leptin level (known as satiety hormone) and insulin resistance, respectively [ 154 ]. Observational studies suggest that CPAP might also improve daytime symptoms, quality of life, and the evolution of NAFLD [ 155 ], by decreasing liver enzymes [ 156 , 157 ].…”