Prediction of Muscle Viability after Electrical Burn Necrosis

Sayman, Haluk; Urgancioglu, I; Uslu, İlhami; Kapicioglu, T

doi:10.1097/00003072-199205000-00012

Cited by 16 publications

(5 citation statements)

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“…Over the past two decades, radiotracer imaging has been used to assess the extent of damage in electrical injury victims [43][44][45][46][47][48]. Radiotracer imaging can delineate necrotic regions from viable tissue by visualizing the altered metabolism or function in these regions.…”

Section: Radiotracer Imaging Of Electrical Injurymentioning

confidence: 99%

Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model

Matthews

Aarsvold

Mintzer

et al. 2006

Burns

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Behavior of (99m)Tc PYP in electroporated muscle appears to be an indicator of the amount of electroporation injury. Compared to saline, intravenous polaxamer-188 treatment reduced the amount of (99m)Tc PYP uptake. Coupled to results showing poloxamer-188 seals ruptured cellular membranes, lessens the extent of electroporation injury and improves cell viability, (99m)Tc PYP imaging appears to be a useful in vivo monitoring tool for the extent of electroporation injury.

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Section: Radiotracer Imaging Of Electrical Injurymentioning

confidence: 99%

Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model

Matthews

Aarsvold

Mintzer

et al. 2006

Burns

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“…The results of blood flow measurements with 99mTc pertechnetate are not always reproducible and reliable, and determination of viability at the cellular level is doubtful with this method [18,19]. 99mTc-sestamibi has been found to be an appropriate radionuclide agent for the imaging of perfusion of the lower extremities [20][21][22][23][24][25][26][27][28][29][30]. Its cellular uptake and trapping are related not only to regional blood flow but also to mitochondrial metabolic conditions and viability [31].…”

Section: Discussionmentioning

confidence: 99%

Ischemic Muscle Necrosis of Lower Extremities in Peripheral Arterial Disease: The Impact of 99mTc-MDP Scintigraphy on Patient Management

et al. 2019

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Background and objectives: The objective of this study was to assess the value of a whole-body bone scintigraphy using 99m technetium labelled-methyl diphosphonate (99mTc-MDP) for the diagnosis and the assessment of grades of muscle damage after prolonged acute or chronic obstruction of the main arteries in lower extremities. Material and Methods: Fifty consecutive patients were selected for the study. The patients’ condition had not improved after primary peripheral arterial reconstruction operation or limb amputation and after conservative treatment. The clinical suspicion was of arterial obstruction and muscle necrosis. All the patients underwent whole-body scintigraphy with 99mTc-MDP. Muscle necrosis was identified as an increased soft tissue uptake of 99mTc-MDP. Results: Forty-five patients had gross muscle necrosis detected on whole-body scintigraphy with 99mTc-MDP and were histologically confirmed after repeated surgery (necrectomy or amputation) or by muscle biopsy, if only fasciotomy was performed. The location and extent of muscle injury were assessed preoperatively and the findings were confirmed in all 45 patients. Twelve patients with clinically suspected minor muscle damage, which was confirmed as relatively minor muscle necrosis on 99mTc-MDP scintigraphy, were treated conservatively. The clinical outcome of all 50 patients was favorable. The 99mTc-MDP scintigraphy, in detection of muscular necrosis, demonstrated sensitivity, specificity, and accuracy of 97.3% (95% confidence interval (CI) 85.4 to 99.3%), 30.77% (95% confidence interval (CI) 9.09 to 61.43%), and 80% (95% confidence interval (CI) 66.28 to 89.97%), respectively. Conclusion: The 99mTc-MDP scintigraphy is a valuable tool in the detection of muscular necrosis. It is able to define location, extent, and grade of involvement. Therefore, it has a clinical impact in patient management, allowing clinicians to select adequate treatment policy and specify the scope of necrectomy.

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“…Bone scanning has been used to assess and predict bone viability in frostbite injuries, burns, and meningococcal septicemic injuries – . Although the use of bone scans for diagnosis of ONFH remains controversial, it has been successfully utilized in assessing bone viability after FVFG . The femoral head is anatomically difficult to evaluate in detail by planar studies.…”

Section: Discussionmentioning

confidence: 99%

Femoral head bone viability after free vascularized fibular grafting for osteonecrosis: SPECT/CT study

et al. 2015

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Prediction of Muscle Viability after Electrical Burn Necrosis

Cited by 16 publications

References 0 publications

Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model

Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model

Ischemic Muscle Necrosis of Lower Extremities in Peripheral Arterial Disease: The Impact of 99mTc-MDP Scintigraphy on Patient Management

Femoral head bone viability after free vascularized fibular grafting for osteonecrosis: SPECT/CT study

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