Prediction of misfolded proteins spreading in Alzheimer’s disease using machine learning and spreading models
Luca Gherardini,
Aleksandra Zajdel,
Lorenzo Pini
et al.
Abstract:The pervasive impact of Alzheimer’s disease on aging society represents one of the main challenges at this time. Current investigations highlight 2 specific misfolded proteins in its development: Amyloid-$\beta$ and tau. Previous studies focused on spreading for misfolded proteins exploited simulations, which required several parameters to be empirically estimated. Here, we provide an alternative view based on 2 machine learning approaches which we compare with known simulation models. The first approach appli… Show more
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