Prediction of major postoperative complications and survival for locally advanced esophageal carcinoma patients

Sunpaweravong, Somkiat; Ruangsin, Sakchai; Laohawiriyakamol, Supparerk; Mahattanobon, Somrit; Geater, Alan

doi:10.1016/j.asjsur.2012.04.029

Cited by 44 publications

(44 citation statements)

References 27 publications

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“…Nutrition in patients with EC is often compromised and malnutrition was suggested as a risk factor for AL [5]. We however could not identify a correlation between AL and preoperative hypoalbuminaemia, severe weight loss preoperatively or low BMI.…”

Section: Discussionmentioning

confidence: 62%

“…Pulmonary complications and failure of the oesophagogastric anastomotic site remain an important source of postoperative morbidity and mortality, despite a clear trend of decreasing incidences of both morbidity and mortality after oesophagectomy over the past decades. The reported leakage incidence after oesophagectomy ranges from 5% to up to 20%, with cervical anastomosis being more prone to leaks but most often with less leak-associated mortality [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors and consequences of anastomotic leakage after Ivor Lewis oesophagectomy

Daele

Putte

Ceelen

et al. 2015

Interact CardioVasc Thorac Surg

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Risk factors and consequences of anastomotic leakage after Ivor Lewis oesophagectomy

Daele

Putte

Ceelen

et al. 2015

Interact CardioVasc Thorac Surg

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show abstract

“…It was mentioned that preservation of the splenic hiatal route would maintain blood flow to the top of the reconstructed stomach. Sunpaweravong et al [20] mentioned that nutrition in patients with esophageal cancer is often compromised and this information suggested that malnutrition is a risk factor for AL. van Rossum et al [21] mentioned that atherosclerotic calcification of the aorta and right postceliac arteries, which supply the gastric tube, is an independent risk factor for AL after esophagectomy.…”

Section: Discussionmentioning

confidence: 99%

The Risk Factors for Refractory Fistula after Esophagectomy with Gastric Tube Reconstruction in Patients with Esophageal Cancer

et al. 2016

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Background/Aims: Anastomotic leakage (AL) after esophagectomy is associated with high rates of postoperative morbidity and mortality. In cases with leakage, a refractory fistula (RF) is sometimes recognized after esophagectomy. The aim of this study was to evaluate the risk factors for RF after esophagectomy with gastric tube reconstruction. Methods: This study enrolled 244 consecutive esophageal cancer patients who had undergone esophagectomy with gastric tube reconstruction. RF was defined as a noncurative anastomotic site-cutaneous fistula that had been present for more than 2 months. We evaluated the risk factors for RF. Results: AL occurred in 30 patients (12.3%). There was one mortality case (0.4%) due to mediastinitis caused by AL in the present series. A multivariate analysis revealed that the subcutaneous route was an independent risk factor for AL (OR 4.42, 95% CI 1.42-13.8, p = 0.01), and that the subcutaneous route was an independent risk factor for RF (OR 13.30, 95% CI 2.50-71.30, p = 0.0024). Conclusion: The results of this retrospective study suggest that subcutaneous route was associated with an increased risk of RF after esophagectomy with gastric tube reconstruction. The preoperative identification of risk factors may contribute to the prevention of postoperative AL and RF.

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“…Although the standard treatment for esophageal cancer is surgery, the frequency of serious complications and the death rate related to surgery are higher than those of other digestive organ cancers . Previous reports have shown that the treatment‐related mortality rate from thoracic esophageal cancer surgery is 3.8–7.9% . Radiotherapy alone has been used to treat elderly patients, those with medically inoperable cancer, those with generalized poor functional capacity, and patients who decline surgery.…”

Section: Introductionmentioning

confidence: 99%

Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I–III esophageal cancer

et al. 2016

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The effect of proton beam therapy (PBT) on various cancers is controversial. We aimed to evaluate the efficacy and safety of PBT with alternating chemoradiotherapy (ACRT) for patients with stage I–III esophageal cancer. Two cycles of systemic chemotherapy with a continuous infusion of 5‐fluorouracil (5‐FU) on days 1–5 and a 5h infusion of nedaplatin (NDP) on day 6 were accompanied by thoracic irradiation using X‐ray therapy and PBT. During the first half of the treatment, X‐rays were delivered to the prophylactic area. During the second half of the treatment, proton beams were used to irradiate the involved field. To reduce the dose of cardiac irradiation, proton beams were delivered with posterior and posterior oblique angles. Between January 2009 and December 2012, 47 patients were enrolled in this study. The median follow‐up duration was 29 months for all patients and 40 months for survivors. The 3 year overall survival rate, progression‐free survival rate, and local control rate were 59.2%, 56.3%, and 69.8%, respectively. With respect to grade 3–4 late toxicities, there were no pleural or pericardial effusions, but two patients (4.3%) had esophageal stenosis, one patient (2.1%) had fistula, and two patients (4.3%) developed radiation pneumonitis. PBT with ACRT might have the potential to reduce the risk of cardiac damage and might become one of the primary methods of esophageal cancer treatment.

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Prediction of major postoperative complications and survival for locally advanced esophageal carcinoma patients

Cited by 44 publications

References 27 publications

Risk factors and consequences of anastomotic leakage after Ivor Lewis oesophagectomy

Risk factors and consequences of anastomotic leakage after Ivor Lewis oesophagectomy

The Risk Factors for Refractory Fistula after Esophagectomy with Gastric Tube Reconstruction in Patients with Esophageal Cancer

Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I–III esophageal cancer

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