Prediction of lymph-node metastasis and lymphatic invasion of superficial pharyngeal cancer on narrow band imaging with magnifying endoscopy

Katada, Chikatoshi; Okamoto, Tabito; Ichinoe, Masaaki; Sakamoto, Yasutoshi; Kano, Koichi; Hosono, Hiroshi; Miyamoto, Shunsuke; Tanabe, Satoshi; Koizumi, Wasaburo; Yamashita, Taku

doi:10.1016/j.anl.2019.04.008

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…The findings of previous reports on ME‐NBI for pharyngeal cancer are summarized in Table 6 17,19–23 . Pharyngeal carcinoma with B2–B3 vessels has been reported to be significantly more likely to show SEP 17,21 .…”

Section: Discussionmentioning

confidence: 93%

“… 17 , 19 , 20 , 21 , 22 , 23 Pharyngeal carcinoma with B2–B3 vessels has been reported to be significantly more likely to show SEP. 17 , 21 Furthermore, there are a few reports on the correlation between B vessels and tumor thickness. 22 , 23 In this study, the tumor thickness was significantly greater in the order of B1, B2, and B3 vessels, suggesting that the thickness of the tumor, which may be a risk factor for LNM, can be predicted by observing the microvascular pattern. In gastrointestinal cancers, if the depth of the tumor is shallower than the mucosal layer, there is almost no chance of LNM.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of previous reports on ME-NBI for pharyngeal cancer are summarized in Table 6. 17,[19][20][21][22][23] Pharyngeal carcinoma with B2-B3 vessels has been reported to be significantly more likely to show SEP. 17,21 Furthermore, there are a few reports on the correlation between B vessels and tumor thickness. 22,23 In this study, the tumor thickness was significantly greater in the order of B1, B2, and B3 vessels, suggesting that the thickness of the tumor, which may be a risk factor for LNM, can be predicted by observing the microvascular pattern.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

et al. 2022

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Backgrounds The pharynx has no muscularis mucosae, so it is unclear whether diagnostic techniques used for the esophagus can be applied to the pharynx. This study investigated the usefulness of magnifying endoscopy with narrowband imaging using the Japan Esophageal Society (JES) classification for predicting the depth of invasion and lymph node metastasis (LNM) in pharyngeal cancer. Methods A total of 123 superficial pharyngeal carcinoma lesions that had been observed preoperatively with magnifying endoscopy with narrowband imaging between January 2014 and June 2021 were analyzed. Predictors of subepithelial invasion (SEP) and LNM were sought based on endoscopic findings, including microvascular morphology, using the JES classification. Results The lesions were divided into carcinoma in situ ( n = 41) and SEP ( n = 82). Multivariate analysis identified B2–B3 vessels (odds ratio [OR] 6.54, 95% confidence interval [CI] 1.74–24.61, p = 0.005) and a middle/large avascular area (OR 4.15, 95% CI 1.18–14.62, p = 0.027) as independent predictors of SEP. Significant predictors of LNM were protruding type, B2–B3 vessels, middle/large avascular area, SEP, venous invasion, lymphatic invasion, and tumor thickness > 1000 μm. Median tumor thickness increased significantly in the order of B1 < B2 < B3 vessels (B1, 305 μm; B2, 1045 μm; B3, 4043 μm; p < 0.001). The LNM rates for B1, B2, and B3 vessels were 1.6% (1/63), 4.8% (2/42), and 55.6% (10/18), respectively ( p < 0.001). Conclusions Magnifying endoscopy with narrowband imaging using the JES classification could predict the depth of invasion in superficial pharyngeal carcinoma. The JES classification may contribute to the prediction of LNM, suggesting that it could serve as an alternative to tumor thickness.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

et al. 2022

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“…As predictors for tumor thickness, Eguchi et al have demonstrated a significant correlation between the classification of type B vessels and tumor thickness in superficial pharyngeal cancer (20). Katada et al also have reported on the substantial correlation between the classification of type B vessels and synchronous lymph node metastasis/lymphatic invasion in superficial pharyngeal cancer (21). In the current study, among the parameters showing a significant correlation with CLNM, the classification of type B vessels was significantly associated with tumor thickness (Table 4).…”

Section: Association Between Tumor Thickness and Classification Of Ty...mentioning

confidence: 98%

“…Additionally, we classified the depth of invasion in SHNC as either EP (tumor located in the epithelium, equivalent to carcinoma in situ) or SEP (tumor involving the subepithelial layer). Tumor thickness, defined as the distance from the tumor surface to the deepest point of tumor invasion (3,20,21), was measured in the SEP tumors.…”

Section: Analysis Of Predictive Factorsmentioning

confidence: 99%

Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma

et al. 2022

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BackgroundEarly detection of head and neck carcinoma (HNC) as superficial HNC (SHNC) identified using recently developed optical techniques, such as magnifying endoscopy and narrow-band imaging (NBI), in combination with endoscopic surgeries enables minimally invasive treatment with favorable outcomes for HNC. This study aimed to identify the predictive factors for the rare but important clinical issue of SHNC, namely cervical lymph node metastasis (CLNM), following endoscopic resection.MethodsSixty-nine patients with SHNC who underwent endoscopic resection were enrolled in the study. Clinical data, preoperative endoscopic findings, pathological findings, and treatment outcomes were retrospectively reviewed. Because the pharyngeal mucosa lacks the muscularis mucosa, we measured tumor thickness in permanent pathology as an alternative to the depth of invasion. Correlations with the occurrence of CLNM were statistically examined.ResultsThe 5-year disease-specific survival rate was 100%. Of 69 patients, 3 (4.3%) developed CLNM. All had subepithelial but not epithelial tumors. The 0-IIa type in the macroscopic findings, type B2/B3 vessels in narrow-band imaging, tumors ≥ pathological stage T2, lymphatic invasion, positive surgical margins, and tumor thickness >1,000 μm showed significant correlations with CLNM following endoscopic resection. Furthermore, the classification of type B vessels was significantly associated with tumor thickness.ConclusionThe treatment outcomes following endoscopic resection for SHNC were favorable. The risk of CLNM following endoscopic resection in SHNC can be predicted by several preoperative endoscopic and postoperative pathological findings. Among them, the classification of type B vessels, which correlated with both tumor thickness and CLNM, might be a useful predictive factor.

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Le Narrow-Band Imaging dans la pratique otorhinolaryngologique carcinologique : état de l’art

Chabrillac

Dupret‐Bories

Vairel

et al. 2021

Annales françaises d'Oto-rhino-laryngologie et de Pathologie Ce

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Prediction of lymph-node metastasis and lymphatic invasion of superficial pharyngeal cancer on narrow band imaging with magnifying endoscopy

Cited by 7 publications

References 32 publications

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society classification

Predicting Cervical Lymph Node Metastasis Following Endoscopic Surgery in Superficial Head and Neck Carcinoma

Le Narrow-Band Imaging dans la pratique otorhinolaryngologique carcinologique : état de l’art

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