Prediction of Life Expectancy in Prostate Cancer Patients Based on the Kinetic Theory of the Aging of Living Systems

Viktorov, A. A.; Zharinov, G. M.; Neklasova, N.Yu.; Morozova, E. E.

doi:10.1134/s2079057017040142

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Its incidence is also the second among all malignant tumors in men worldwide [1, 3]. For the past few years, the occurrence rate of prostate cancer in males has increased year by year, which is closely related to the continuous growth of life expectancy, the aging of the population, the change of diet structure and the continuous improvement of diagnostic techniques [4–6]. Prostate cancer poses a heavily threat to the health and life of men, particularly in the middle and late stages.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p

Wang¹,

Wang²,

Wu³

et al. 2019

Cancer Cell Int

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BackgroundCircular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) is significantly down-regulated in various kinds of tumors, however, the mechanisms of action and functions of circITCH gene in prostate cancer (PC) are still under investigation. The mail goal of this research was to study the functional role of Circ-ITCH gene in prostate cancer and to illuminate the function role of circ-ITCH gene in prostate cancer by targeting miR-17-5p/HOXB13.MethodsRT-qPCR was applied to measure the expression level of circ-ITCH and miR-17-5p in PC cell lines and tissues. CCK-8, colony formation, Brdu incorporation labeling and flow cytometry assays were applied to detect the effects of circ-ITCH and miR-17-5p on proliferation and cell apoptosis. Target gene prediction and screening, luciferase reporter gene assays were utilized to assess downstream target genes of miR-17-5p and Circ-ITCH. The protein and expression of HOXB13 gene were measured by Western blotting and RT-qPCR.ResultsCircITCH was significantly reduced in PC cell lines and tissues. Low circITCH expression level was highly related with preoperative PSA, tumor stage and Gleason score. Overexpression of circITCH can inhibit the malignant phenotype of prostate cancer. There was a high negative relationship between the expression level of microRNA-17-5p and circITCH in PC tissues, however, there existed a positive relationship between the expression of HOXB13 and circITCH. CircITCH acted as a sponge of miR-17-5p to increase HOXB13 gene expression. In addition, miR-17-5p overexpression or HOXB13 silencing can reduce the carcinogenic effects of circICCH in prostate cancer.ConclusionCircITCH promoted prostate cancer progression by regulating the HOXB13/miR-17-5p axis, and circITCH have a potential usage as therapeutic target for PC tumors.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p

Wang¹,

Wang²,

Wu³

et al. 2019

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

“…A continuous increase in the incidence of PCa in China has been noted in the past few decades, 1 which is closely associated with the aged tendency of the population, the changes in dietary pattern and the advancement in diagnostic technology. 2,3 Accumulating studies have reported the vital functions of the androgen receptor (AR) and several other pivotal molecules in PCa development. 4,5 After endocrine therapy, most of the PCa patients eventually develop into castration-resistant prostate cancer (CRPC), which is resistant to chemo-or radio-therapy.…”

Section: Introductionmentioning

confidence: 99%

Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling

Li¹,

Wang²,

Li³

et al. 2021

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Prediction of Life Expectancy in Prostate Cancer Patients Based on the Kinetic Theory of the Aging of Living Systems

Cited by 2 publications

References 7 publications

RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p

RETRACTED ARTICLE: Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p

Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling

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