Prediction of kidney graft failure using clinical scoring tools

Gourishankar, Sita; Grebe, Scott O.; Mueller, Thomas

doi:10.1111/ctr.12135

Cited by 31 publications

(17 citation statements)

References 36 publications

(69 reference statements)

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“…On the other hand, KDRI showed the best correlation with both recipient one‐yr renal function and graft survival. Since the development of the KDRI by Rao , the KDRI has been shown to be a good prognostic tool for graft outcome in regions with mean CIT over 17 h . Our data showed that the KDRI is also a good prognostic tool for graft outcome even in regions with short CIT, in contrast to the UNOS criteria for ECD that does not have a good prognostic value.…”

Section: Discussionmentioning

confidence: 58%

Kidney donor risk index is a good prognostic tool for graft outcomes in deceased donor kidney transplantation with short, cold ischemic time

Jeong

Koo

Jeon

et al. 2014

Clinical Transplantation

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Section: Discussionmentioning

confidence: 58%

Kidney donor risk index is a good prognostic tool for graft outcomes in deceased donor kidney transplantation with short, cold ischemic time

Jeong

Koo

Jeon

et al. 2014

Clinical Transplantation

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“…The DGF risk calculator uses 22 donor, recipient, and organ parameters to calculate the relative risk at DGF (5). This model has been verified and validated in various external cohorts (31,32). However, as stated in the original paper, this algorithm holds true for (large) patient populations, but has limited value for individual patients.…”

Section: Discussionmentioning

confidence: 99%

Proteins in Preservation Fluid as Predictors of Delayed Graft Function in Kidneys from Donors after Circulatory Death

Balkom¹,

Gremmels²,

Ooms

et al. 2017

CJASN

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Background and objectives Kidney transplantation is the preferred treatment for ESRD, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive values for short-and long-term transplantation outcomes, but are invasive and may not reflect the entire organ. Alternative, more representative methods to predict transplantation outcome are required. We hypothesized that proteins accumulating in preservation fluid during cold ischemic storage can serve as biomarkers to predict posttransplantation graft function. Conclusions We demonstrate that donor kidney preservation fluid harbors biomarkers that, together with information on recipient BMI, predict short-term post-transplantation kidney function. Our approach is safe, easy, and performs better than current prediction algorithms, which are only on the basis of clinical parameters.

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“…Ultimate baseline creatinine is likely to overwhelmingly be influenced by donorderived features in line with a donor-risk index. 21,22 Future work will focus on more accurate correlation between the pattern or phases of DGF observed and the specific perioperative insults. It may be that interventions and therapies (eg, normothermic reperfusion) are found to alter the pattern of DGF observed.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Aitken

Cooper²,

Dempster³

et al. 2015

Exp Clin Transplant

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Objectives: Delayed graft function is a significant prognostic indicator after renal transplantation. We hypothesized that delayed graft function is not a single entity, and different patterns of delayed graft function reflect various underlying pathological processes. Materials and Methods: An analysis of 762 renal transplants was performed, showing serum creatinine was charted serially for the first 30 days after transplant. Measurements were obtained: time on hemodialysis; time to peak creatinine; time for creatinine to half; time for creatinine to within 10% of baseline. Results: Four patterns of delayed graft function were identified. There was no association between pattern of delayed graft function, and 1-year graft survival or serum creatinine at 1 year. Time for creatinine to >15 days was associated with a higher creatinine level at 1 year than it was with patients with time for creatinine to half < 5 days (300.6 ± 54.3 vs 211.3 ± 26.0 μmol/L; P < .01). Patients with 1-year creatinine concentrations > 180 μmol/L had longer time on hemodialysis and time for creatinine to half than did those with 1-year creatinine concentrations ≤ 180 μmol/L (9.2 ± 1.3 μmol/L vs 7.0 ± 0.7 μmol/L; P = .03; and 11.6 ± 1.7 μmol/L vs 6.0 ± 0.4 μmol/L; P < .001). Time for creatinine to half of 6.5 days (sensitivity 67.3%; specificity 79.4%; area under the curve, 0.70) was the best predictor of a 1-year creatinine concentration ≤ 180 μmol/L. Conclusions:Delayed graft function is not a single entity; rather; it is the most common presentation of a heterogenous variety of pathologies. Its rate of resolution of renal function is the best predictor of long-term graft outcome.

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Prediction of kidney graft failure using clinical scoring tools

Abstract: Our findings validate four pre-operative clinical scoring tools to predict early and late graft outcome in an independent, single-center set of kidney transplants.

Cited by 31 publications

References 36 publications

Kidney donor risk index is a good prognostic tool for graft outcomes in deceased donor kidney transplantation with short, cold ischemic time

Kidney donor risk index is a good prognostic tool for graft outcomes in deceased donor kidney transplantation with short, cold ischemic time

Proteins in Preservation Fluid as Predictors of Delayed Graft Function in Kidneys from Donors after Circulatory Death

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