2000
DOI: 10.1007/s002040000135
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Prediction of in vivo metabolic clearance of 25 different petroleum hydrocarbons by a rat liver head-space technique

Abstract: In vitro rates of metabolism and Michaelis-Menten constants were determined for 25 different C6 to C10 hydrocarbons using rat liver slices in a vial head-space equilibration system. The rates of metabolism were compared with steady-state levels obtained in vivo in the same strains of rats after inhalation. Aromates were metabolized at a higher rate than naphthenes n-alkanes, isoalkanes and 1-alkenes. The aromates showed, in contrast to the other hydrocarbons investigated, increased metabolism with increasing n… Show more

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Cited by 9 publications
(14 citation statements)
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“…The PCs and metabolic constants required to develop Note: a The experimental values of partition coefficients were obtained from Gargas et al [8] and Smith et al [10]. Experimental values of CL int are from Mortensen et al [12]. chemical-specific PBPK models are most often obtained from in vivo or in vitro studies (reviewed by Krishnan and Andersen [4]).…”
Section: Discussionmentioning
confidence: 99%
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“…The PCs and metabolic constants required to develop Note: a The experimental values of partition coefficients were obtained from Gargas et al [8] and Smith et al [10]. Experimental values of CL int are from Mortensen et al [12]. chemical-specific PBPK models are most often obtained from in vivo or in vitro studies (reviewed by Krishnan and Andersen [4]).…”
Section: Discussionmentioning
confidence: 99%
“…In vitro data on maximal velocity (V max ) and Michaelis-Menten constant (K m ) for 20 C 5 -C 10 VOCs determined using rat liver slices with the vial equilibrium technique were obtained from Mortensen et al [12]. After the calculation of intrinsic clearance (CL int ¼ V max /K m ), these values were used for developing QSPRs.…”
Section: Qspr For CL Intmentioning
confidence: 99%
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“…Michaelis-Menten metabolic constants for n-decane have been measured (Km = 1.5 mg/L and Vmax = 0.4 mg/h) using rat liver slices in a vial headspace equilibration system (Mortensen et al, 2000). These data indicate that clearance via liver metabolism is minimal for n-alkanes, which, in addition to their lipophilicity, contributes to their tendency toward increased body retention.…”
Section: Model Parameterizationmentioning
confidence: 99%
“…Die Ab bau ra te hö he rer ali pha ti scher KW nimmt mit an stei gen der Koh len stoff zahl ab [26]. …”
Section: Me Ta Bo Lis Mus Und Aus Schei Dungunclassified