Prediction of in vitro fertilization outcome at different antral follicle count thresholds combined with female age, female cause of infertility, and ovarian response in a prospective cohort of 8269 women

Abstract

Antral follicle count (AFC) has been widely investigated for the prediction of clinical pregnancy or live birth. This study discussed the effects of AFC quartile levels on pregnancy outcomes combined with female age, female cause of infertility, and ovarian response undergoing in vitro fertilization (IVF) treatment. At present, many research about AFC mainly discuss its impact on clinical practice at different thresholds, or the analyses of AFC with respect to assisted reproductive technology outcomes under using different ovarian stimulation protocols. Factors that include ovarian sensitivity index, female age, and infertility cause are all independent predictors of live birth undergoing IVF/intracytoplasmic sperm injection, while few researchers discussed influence of female-related factors for clinical outcomes in different AFC fields.A total of 8269 infertile women who were stimulated with a long protocol with normal menstrual cycles were enrolled in the study, and patients were categorized into 4 groups based on AFC quartiles (1–8, 9–12, 13–17, and ≥18 antral follicles).The clinical pregnancy rates increased in the 4 AFC groups (28.25% vs 35.38% vs 37.38% vs 40.13%), and there was a negative association between age and the 4 AFC groups. In addition, female cause of infertility like polycystic ovary syndrome, Tubal factor, and other causes had great significance on clinical outcome, and ovarian response in medium (9–16 oocytes retrieved) had the highest clinical pregnancy rate at AFC quartiles of 1 to 8, 9 to 12, 13 to 17, and ≥18 antral follicles.This study concludes that the female-related parameters (female cause of infertility, female age, and ovarian response) combined with AFC can be useful to estimate the probability of clinical pregnancy.

Anti‐Müllerian hormone and antral follicle count differ in their ability to predict cumulative treatment outcomes of the first complete ovarian stimulation cycle in patients from POSEIDON groups 3 and 4

“…Although many studies have proposed different cut-off values for correlations of AMH and AFC with clinical pregnancy and live birth after IVF/ICSI in patients with varying ovarian reserve, [8][9][10][11][12][13][14][15][16][17] none have focused on the difference in predictive ability between AMH and AFC in the same complete OS cycle of IVF/ICSI, including fresh and frozenthawed embryo transfer cycles. Moreover, no studies have assessed AMH and AFC as predictors of cumulative treatment outcomes of IVF/ICSI among patients with POSEIDON expected low ovarian response.…”

Cell‐specific network analysis of human folliculogenesis reveals network rewiring in antral stage oocytes

“…By integrating the classical WGCNA into the novel CSN analysis, our research aimed to explore the gene functions of follicles, especially at antral stage. Antral stage is an important period in folliculogenesis as antral follicle status plays a critical role in ovarian functions and influence reproductive abilities 6‐8 . The biomarkers specific to the antral stage follicle are also representative indicators for the prediction of ovarian response in fertility treatments 8,9 …”

“…Antral stage is an important period in folliculogenesis as antral follicle status plays a critical role in ovarian functions and influence reproductive abilities. [6][7][8] The biomarkers specific to the antral stage follicle are also representative indicators for the prediction of ovarian response in fertility treatments. 8,9 In this study, ten co-expression gene modules were constructed using the most highly variable genes in 151 oocytes and GCs.…”

“…[6][7][8] The biomarkers specific to the antral stage follicle are also representative indicators for the prediction of ovarian response in fertility treatments. 8,9 In this study, ten co-expression gene modules were constructed using the most highly variable genes in 151 oocytes and GCs. functions.…”

Anais Da Feira Acadêmica by Acervo Saúde

“…A infertilidade é a incapacidade de o casal engravidar e ter um filho após um ano ou mais de tentativas sem proteção, ocorrendo entre 8-12% dos casais (BORGHT MV& WYNS C, 2018). Sabe-se que a idade da mulher está inversamente relacionada a sua capacidade reprodutiva ( LIAO S, et al, 2019). Os tratamentos com técnica de reprodução assistida possibilitam aos casais, inclusive às mulheres com mais de 35 anos, maiores chances de êxito conseguirem engravidar.…”