Prediction of histologic types in solid lung lesions using preoperative contrast-enhanced CT

Cui, Xiaonan; Zheng, Sunyi; Zhang, Wenjia; Fan, Shuxuan; Wang, Jing; Song, Fei; Liu, Xu; Zhu, Weijie; Ye, Zhaoxiang

doi:10.1007/s00330-023-09432-3

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…For those types of lesions, ultrasound study, including contrastography, by using EBUS could provide further diagnostic indications [28,29]. Therefore, the tomographic method with contrast medium currently remains the diagnostic gold standard [30][31][32]. CEUS in the context of transthoracic ultrasound can be used as an initial detection and screening tool for subpleural lung consolidation, but above all as a guiding tool for biopsy procedures and follow-up [33,34].…”

Section: Strengths and Limitations Of Ceus Characterization Of Subple...mentioning

confidence: 99%

The Role of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Malignant and Benign Subpleural Lung Lesions

Boccatonda,

Guagnano,

D’Ardes

et al. 2024

JCM

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Background: The application of transthoracic contrast-enhanced ultrasound (CEUS) to the study of peripheral lung lesions is still a topic of debate. The main objective of this review was to evaluate the diagnostic accuracy of CEUS in the diagnosis of malignant subpleural pulmonary consolidations and, therefore, differentiate them from benign ones. Methods: Papers published before December 2023 were detected through a search of PubMed, Cochrane library, and Embase. The pooled specificity and sensitivity, summary receiver operating characteristic (SROC) curve and diagnostic odds ratio (DOR) were used. Results: CEUS is characterized by a pooled sensitivity of 0.95 (95% CI: 0.93–0.97) and a pooled specificity of 0.93 (95% CI: 0.90–0.95) in differentiating benign and malignant subpleural lung diseases; the AUC of SROC was 0.97. Homogeneous CE was characterized by a pooled sensitivity of 0.43 (95% CI: 0.40–0.45) and the pooled specificity of 0.49 (95% CI: 0.46–0.52). Non-homogeneous CE displayed a pooled sensitivity of 0.57 (95% CI: 0.55–0.60) and a pooled specificity of 0.51 (95% CI: 0.48–0.54). The lack of CE displayed a pooled sensitivity of 0.01 (95% CI: 0.00–0.06) and a pooled specificity of 0.76 (95% CI: 0.64–0.85). Marked CE displayed a pooled sensitivity of 0.41 (95% CI: 0.37–0.44) and a pooled specificity of 0.54 (95% CI: 0.50–0.58). Non-marked CE displayed a pooled sensitivity of 0.59 (95% CI: 0.56–0.63) and a pooled specificity of 0.46 (95% CI: 0.42–0.50). The early AT displayed a pooled sensitivity of 0.04 (95% CI: 0.02–0.08) and a pooled specificity of 0.83 (95% CI: 0.77–0.87). The early wash out displayed a pooled sensitivity of 0.61 (95% CI: 0.48–0.72) and a pooled specificity of 0.98 (95% CI: 0.92–1.00). The delayed wash out displayed a pooled sensitivity of 0.15 (95% CI: 0.10–0.20) and a pooled specificity of 0.69 (95% CI: 0.62–0.75). Conclusions: CEUS is characterized by excellent diagnostic accuracy for the diagnosis of the malignancy of subpleural lung lesions. By separately analyzing the CEUS findings, the diagnostic accuracy values are considerably lower and not significant in some cases. The simultaneous evaluation of multiple CEUS features allows us to reach an excellent diagnostic accuracy. Non-homogeneous CE with early wash out are the most indicative features of malignancy of a lung lesion.

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