Prediction of Hearing Outcomes by Multiple Regression Analysis in Patients With Idiopathic Sudden Sensorineural Hearing Loss

Suzuki, Hideaki; Tabata, Toshihide; Koizumi, Hiroki; Hohchi, Nobusuke; Takeuchi, Shoko; Kitamura, Takuro; Fujino, Yoshihisa; Ohbuchi, Toyoaki

doi:10.1177/0003489414538606

Cited by 30 publications

(28 citation statements)

References 22 publications

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“…Although predicting the prognosis in advance is of primary interest to SSHL patients and physicians, very few studies have covered this theme and they usually involved traditional models based on regression methods or Bayesian survival analysis. Those studies did not focus on the prediction of dichotomised hearing outcome, but rather on prediction of the time to improvement with the best ROC‐AUC of 0.807 or hearing improvement rate with the highest predicable probability of 70%, thus disabling direct comparison with our study.…”

Section: Discussionmentioning

confidence: 93%

“…Suzuki H et al developed a regression model with four predictors including initial hearing threshold, age, the presence of vertigo and time from onset to treatment, achieving predicable probability of 70% but a wide prediction interval (40 dB) and low multiple correlation coefficient (0.495). Recently they improved the multiple correlation coefficient (0.714) for their predictive model by adding three more predictors (contralateral hearing level, initial hearing level at low frequencies and at high frequencies) . Chao TK and Chen T established a Bayesian cure rate model by inputting eight variables, predicting the time to improvement in idiopathic SSHL patients, with the area under the receiver operator characteristic curves (ROC‐AUC) at the 7th, 14th and 30th days were 0.709, 0.752 and 0.807, respectively …”

Section: Introductionmentioning

confidence: 99%

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Predicting the hearing outcome in sudden sensorineural hearing loss via machine learning models

Dai

Ying

Miao

et al. 2018

Clinical Otolaryngology

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Predicting the hearing outcome in sudden sensorineural hearing loss via machine learning models

Dai

Ying

Miao

et al. 2018

Clinical Otolaryngology

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“…8 In earlier literature, older age in treated ISSNHL patients tends to be associated with a worse prognosis [12][13][14][15] or no change in hearing improvement. [16][17][18] One prospective, longitudinal cohort study of 127 ISSNHL patients found no significant difference in PTA recovery rates in the various age groups studied (30, 31-50, 51-70, 71 years old), but did note a trend in poorer results in the more extreme age groups (30, 71 years old) 19 Attanasio et al 20 found increased age was associated with worse hearing outcomes in their study of 496 patients; on subgroup analysis divided by age >65 years old, patients in the older subgroup had a statistically significant higher PTA both pre-and posttreatment.…”

Section: Discussionmentioning

confidence: 99%

Oral and intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss

Hara

Zhang

Gandhi

et al. 2018

Laryngoscope Investig Oto

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ObjectiveTo investigate the role of intratympanic (IT) therapy in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL).MethodsThis study was a retrospective review. Patients were treated for ISSNHL from January 1, 2011 to April 12, 2015 with the following: pre/posttreatment audios, treatment initiated ≤90 days and idiopathic etiology. Fifty‐three ISSNHL patients were analyzed in the following subgroups: oral steroids (n = 8), combination oral+IT (n = 39), and IT (n = 6). Main outcomes measured were pre/posttreatment pure tone average (PTA) scores.ResultsThe PTA changes for all treatment groups improved by 8.0 ± 19.5 dB (P = .004); for 31 patients treated ≤2 weeks after onset, PTA improved by 13.8 ± 16.6 dB (P < .001). Multivariable generalized linear model for repeated measures was conducted to investigate the association between PTA changes for treatment groups adjusted for age, gender, time‐to‐treatment, and vertigo. Earlier time‐to‐treatment and older age were statistically correlated towards improved outcomes. As time‐to‐treatment increased by each day, change in PTA decreased by 0.324 (95% CI [0.12, 0.52], P = .002). As age increased by each year, PTA changes increased by 0.802 (95% CI [0.36, 1.24], P < .001). For the oral+IT group, PTA changes for concurrent oral+IT (n = 20, 7.10 dB) and delayed/salvage oral+IT (n = 19, 5.43 dB) were not statistically different (P = .79); earlier time‐to‐treatment (P = .001), and older age (P = .006) remained statistically correlated towards improved outcomes.ConclusionResults suggest outcomes can be improved with early identification and oral steroid therapy by primary care providers. Poorer prognosis for younger patients potentially suggests a need for more aggressive diagnostic and therapeutic management for this subgroup.Level of Evidence3b.

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“…The association between the subjective perception of vertigo and worse outcome could be demonstrated by several studies [32, 33, 36–45]. But, the association between objective calorimetric tests and hearing outcome was only investigated by a few [29, 31, 32].…”

Section: Discussionmentioning

confidence: 99%

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Weiß

Böcker

Koopmann³

et al. 2017

J of Otolaryngol - Head & Neck Surg

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BackgroundSudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient’s social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not predictable.MethodsWe conducted a retrospective study in order to identify parameters that influence hearing recovery. The data base contains results of basic otoneurological tests and clinical parameters of 198 patients with idiopathic SSHL of at least 60 dB in at least four frequencies, diagnosed and treated at the University Hospital of Münster, Germany, between 1999 and 2015. Hearing recovery was measured by pure tone audiometry.ResultsMultivariate linear and logistic regression analyses indicate that the chance as well as the magnitude of hearing recovery is higher for patients with normal caloric testing than for patients with pathological caloric testing. However, for the subgroup of patients who attained a hearing recovery, the caloric testing result was not found to influence the magnitude. Instead, the magnitude was noticeably lower for patients within this subgroup who had a previous hearing loss. Furthermore, we found indications that the magnitude is higher for men than for women and that receiving a high-dose steroid therapy is associated with a higher chance and magnitude of a hearing recovery.ConclusionsWe conclude that SSHL associated with disorders of the vestibular system or previous hearing loss represent special sub-entities of SSHL that may be caused by unique pathophysiological mechanisms and are associated with worse outcome. Furthermore, our data support the importance of elevated dosage of steroids in SSHL therapy.

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Prediction of Hearing Outcomes by Multiple Regression Analysis in Patients With Idiopathic Sudden Sensorineural Hearing Loss

Abstract: Prediction of HLpost by the multiple regression model may be useful to estimate the hearing prognosis of ISSNHL.

Cited by 30 publications

References 22 publications

Predicting the hearing outcome in sudden sensorineural hearing loss via machine learning models

Predicting the hearing outcome in sudden sensorineural hearing loss via machine learning models

Oral and intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

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