Steam or gases other than air have been proposed as substitutes for cooling industrial turbine components positioned along the hot gas path. To check the effect of coolant gas physical properties on the internal passage heat transfer coefficients, tests were conducted with air, helium, carbon dioxide, and refrigerant-12 in a serpentine passage with turbulence promoters. For the fully developed turbulent flow regions, the correlation proposed by Han et al. (1985) properly accounts for the cooling gas property changes. With respect to the external heat transfer aspects with film cooling, tests were run in a wind tunnel with a two-dimensional slit injection geometry. The film cooling effectiveness results measured with the same gases injected as a secondary gas into the main flow of air show that the correlations proposed by Kutateladze and Leont’ev (1963) and Librizzi and Cresci (1964) agree with the present data for the air/air, air/helium, and air/carbon dioxide combinations. The air/refrigerant-12 results are lower than all the correlations proposed in the literature.