Prediction of femoral fracture load using automated finite element modeling

Keyak, Joyce H.; Rossi, Stephen A; Jones, Kimberly; Skinner, Harry B.

doi:10.1016/s0021-9290(97)00123-1

Cited by 585 publications

(484 citation statements)

References 33 publications

Supporting

Mentioning

446

Contrasting

Unclassified

Order By: Relevance

“…Keyak and coauthors [4][5][6][7] have championed the development of CT/FE modeling of tumor burdened bone using continuum-based models in which element size is on the order of 3 mm. In contrast to the micro-CT modeling performed in this study, continuum-based models do not directly model the trabecular structure.…”

Section: Discussionmentioning

confidence: 99%

Predicting Distal Femur Bone Strength in a Murine Model of Tumor Osteolysis

Mann

Lee

Arrington

et al. 2008

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Predicting pathologic fractures of long bones caused by metastatic disease continues to be a challenging clinical problem. We assessed the ability of noninvasive imaging and computational techniques to predict the strength of bones with osteolytic lesions. A murine model of induced tumor osteolysis to the distal femur was used as a model system resulting in a wide range of lesion sizes. Microcomputed tomography scans were obtained and specimen-specific, voxel-based, finite element analyses were performed and results were compared with direct measurement of biomechanical strength via axial compressive loading of the distal femur. Additional indirect surrogates of bone strength included dual-energy xray absorptiometry to determine bone mineral density, radiographic scoring, and computed tomography volume/ mineral estimates. Predicted bone strength was weakest (r 2 = 0.55) for the dual-energy xray absorptiometry measure and strongest (r 2 = 0.91) for the direct computed tomography voxel-based, finite element analysis. The relative success of the voxel-based, finite element modeling approach to estimate bone strength in a murine osteolytic tumor model indicates this approach, with further development and validation, could serve as a way to nondestructively estimate bone strength in a clinical setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting Distal Femur Bone Strength in a Murine Model of Tumor Osteolysis

Mann

Lee

Arrington

et al. 2008

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…While the use of QCT-based FE models would have also allowed the estimation of inhomogeneous elastic properties using the voxel-based Hounsfield unit data (density) [11][12][13][18][19][20][21][22], the assumption of homogeneous material properties is acceptable.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Accordingly, it has been speculated that the fracture initiates from this thin cortical layer of the superolateral region [4,7,8]. Several finite element (FE) modeling and cadaveric experimental studies have consistently shown that a sideways fall exposes the femoral neck to the greatest risk of a fracture [7,[9][10][11][12][13]. Indeed, over 90% of hip fractures are directly caused by falls [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…However, the influence of this exercise-induced structural benefit on femoral neck strength in the sideways fall was not examined. Several FE modeling studies have been conducted to obtain a better understanding of the hip fracture mechanism [3,6,9,[11][12][13][18][19][20][21][22]. To the best of our knowledge, however, no FE modeling study has so far been conducted to investigate the influence of specific exercise loading…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exercise loading history and femoral neck strength in a sideways fall: A three-dimensional finite element modeling study

Abe

Narra

Nikander

et al. 2016

Bone

View full text Add to dashboard Cite

“…where 26) are the "effective" body force and "effective" Cauchy stress, respectively. Note that T in (2.26) 2 is the standard Cauchy stress tensor related to the traction vector t according to t = Tn.…”

Section: Linear Momentum Balancementioning

confidence: 99%

Material growth in thermoelastic continua: Theory, algorithmics, and simulation

Vignes

Papadopoulos

2010

Computer Methods in Applied Mechanics and Engineering

View full text Add to dashboard Cite

To this end, a theoretical formulation of stress-induced volumetric material growth in thermoelastic continua is developed. The theory derives, without the classical continuum mechanics assumption of mass conservation, the balance laws governing the mechanics of solids capable of growth. Also, a proposed extension of classical thermodynamic theory provides a foundation for developing general constitutive relations. The theory is consistent 2 in the sense that classical thermoelastic continuum theory is embedded as a special case.Two growth mechanisms, a kinematic and a constitutive contribution, coupled in the most general case of growth, are identified. This identification allows for the commonly employed special cases of density-preserving growth and volume-preserving growth to be easily recovered. In the theory, material growth is regulated by a three-surface activation criterion and corresponding flow rules. A simple model for rate-independent finite growth is proposed based on this formulation. The associated algorithmic implementation, including a method for solving the underlying differential/algebraic equations for growth, is examined in the context of an implicit finite element method. Selected numerical simulations are presented that showcase the predictive capacity of the model for both soft and hard biomaterials. Professor Panayiotis Papadopoulos, Chair i

show abstract

Prediction of femoral fracture load using automated finite element modeling

Cited by 585 publications

References 33 publications

Predicting Distal Femur Bone Strength in a Murine Model of Tumor Osteolysis

Predicting Distal Femur Bone Strength in a Murine Model of Tumor Osteolysis

Exercise loading history and femoral neck strength in a sideways fall: A three-dimensional finite element modeling study

Material growth in thermoelastic continua: Theory, algorithmics, and simulation

Contact Info

Product

Resources

About