Prediction of epidemiological characteristics of vascular cognitive impairment using SIR mathematical model and effect of brain rehabilitation and health measurement system on cognitive function of patients

Hu, Yanqun; Zhong, Wei; Cen, Yunguang; Han, Shuyan; Feng, Zhiyun; Zhang, Xuri; Li, Wei; Wang, Lanhua; Li, Bin; Issa, Sahar; Ismail, Raid A.

doi:10.1016/j.rinp.2021.104331

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…VCIND, as an early stage of VCI, is closely associated with declining cognitive abilities and an increased risk of developing dementia. 6 , 7 Therefore, it is important to note that while VCIND does not meet the criteria for dementia, individuals with this condition are at an increased risk of developing dementia in the future.…”

Section: Introductionmentioning

confidence: 99%

“…According to epidemiological research, the prevalence of VCI among the population aged 65 and above in China is approximately 8.7%, 5 which is an important public health issue. VCIND, as an early stage of VCI, is closely associated with declining cognitive abilities and an increased risk of developing dementia 6,7 . Therefore, it is important to note that while VCIND does not meet the criteria for dementia, individuals with this condition are at an increased risk of developing dementia in the future.…”

Section: Introductionmentioning

confidence: 99%

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Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Li,

Xing,

Zhu

et al. 2024

CNS Neurosci Ther

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AimsPrevious neuroimaging studies of vascular cognitive impairment, no dementia (VCIND), have reported functional alterations, but far less is known about the effects of cognitive training on functional connectivity (FC) of intrinsic connectivity networks (ICNs) and how they relate to intervention‐related cognitive improvement. This study provides comprehensive research on the changes in intra‐ and inter‐brain functional networks in patients with VCIND who received computerized cognitive training, with a focus on the underlying mechanisms and potential therapeutic strategies.MethodsWe prospectively collected 60 patients with VCIND who were randomly divided into the training group (N = 30) receiving computerized cognitive training and the control group (N = 30) receiving fixed cognitive training. Functional MRI scans and cognitive assessments were performed at baseline, at the 7‐week training, and at the 6‐month follow‐up. Utilizing templates for ICNs, the study employed a linear mixed model to compare intra‐ and inter‐network FC changes between the two groups. Pearson correlation was applied to calculate the relationship between FC and cognitive function.ResultsWe found significantly decreased intra‐network FC within the default mode network (DMN) following computerized cognitive training at Month 6 (p = 0.034), suggesting a potential loss of functional specialization. Computerized training led to increased functional coupling between the DMN and sensorimotor network (SMN) (p = 0.01) and between the language network (LN) and executive control network (ECN) at Month 6 (p < 0.001), indicating compensatory network adaptations in patients with VCIND. Notably, the intra‐LN exhibited enhanced functional specialization after computerized cognitive training (p = 0.049), with significant FC increases among LN regions, which correlated with improvements in neuropsychological measures (p < 0.05), emphasizing the targeted impact of computerized cognitive training on language abilities.ConclusionsThis study provides insights into neuroplasticity and adaptive changes resulting from cognitive training in patients with VCIND, with implications for potential therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Li,

Xing,

Zhu

et al. 2024

CNS Neurosci Ther

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SIR-Solution for Slowly Time-Dependent Ratio between Recovery and Infection Rates

Kröger

Schlickeiser

2022

Physics

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The temporal evolution of pandemics described by the susceptible-infectious-recovered (SIR)-compartment model is sensitively determined by the time dependence of the infection (a(t)) and recovery (μ(t)) rates regulating the transitions from the susceptible to the infected and from the infected to the recovered compartment, respectively. Here, approximated SIR solutions for different time dependencies of the infection and recovery rates are derived which are based on the adiabatic approximation assuming time-dependent ratios, k(t)=μ(t)/a(t), varying slowly in comparison with the typical time characteristics of the pandemic wave. For such slow variations, the available analytical approximations from the KSSIR-model, developed by us and valid for a stationary value of the ratio k, are used to insert a posteriori the adopted time-dependent ratio of the two rates. Instead of investigating endless different combinations of the time dependencies of the two rates a(t) and μ(t), a suitably parameterized reduced time, τ, dependence of the ratio k(τ) is adopted. Together with the definition of the reduced time, this parameterized ratio k(τ) allows us to cover a great variety of different time dependencies of the infection and recovery rates. The agreement between the solutions from the adiabatic approximation in its four different studied variants and the exact numerical solutions of the SIR-equations is tolerable providing confidence in the accuracy of the proposed adiabatic approximation.

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The effect of five activities daily living on improving cognitive function in ischemic stroke patients

Andrianur,

Era,

Hidayat

et al. 2023

Healthc Low-resour S

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This study aimed to assess the effects of five activities of daily living (ADL) interventions on improving cognitive function in patients with ischemic stroke. The study employed a quasi-experimental design with 16 ischemic stroke patients (n=8 per group) in an inpatient ward at a regional hospital in Samarinda, Indonesia. Inclusion criteria were: i) confirmed ischemic stroke via medical records, ii) effective communication, iii) current inpatient status, and iv) hemiparesis. Data collection used an ADL activity instrument sheet, while cognitive function was assessed with the MoCA-Ina screening (maximum score: 30 points). Data analysis included the Wilcoxon test and independent T-Test, with significance set at p<0.05. After the intervention, the intervention group's cognitive function significantly improved (from mean 20.25 ± 2.60 to 25.13 ± 1.81), while the control group changed from mean 17.13 ± 2.10 to 20.50 ± 2.00. The intervention group showed a significant cognitive improvement compared to the control group (p < 0.05). In conclusion, ADL interventions enhance cognitive function in ischemic stroke patients, aiding recovery and serving as an effective hospital nursing intervention.

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Prediction of epidemiological characteristics of vascular cognitive impairment using SIR mathematical model and effect of brain rehabilitation and health measurement system on cognitive function of patients

Cited by 3 publications

References 14 publications

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

SIR-Solution for Slowly Time-Dependent Ratio between Recovery and Infection Rates

The effect of five activities daily living on improving cognitive function in ischemic stroke patients

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