Prediction of ecotoxicological behaviour of chemicals: Relationship between physico-chemical properties and bioaccumulation of organic chemicals in the mussel Mytilus edulis

Geyer, Harald J.; Sheehan, Patrick J.; Kotzias, D.; Freitag, D.; Körte, F.

doi:10.1016/0045-6535(82)90122-9

Cited by 166 publications

(51 citation statements)

References 56 publications

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“…The BCF is the ratio of the concentration of compound in mussel tissues to concentration measured in the exposure water. Two predicted values are given for lindane, the Ðrst derived from our published QSAR,5 the second from a QSAR published by Geyer et al 20 The latter QSAR gave a much closer Ðt to the observed data, probably because it was derived using a structurally diverse group of compounds which were predominantly organochlorines. Our QSAR was derived largely with hydrocarbons ; Pruell et al 47 showed that under identical exposure conditions, the BCF of polychlorinated biphenyls (PCBs), which like lindane are chlorinated hydrocarbons, was greater than that of unsubstituted hydrocarbons.…”

Section: Organochlorine Compoundsmentioning

confidence: 95%

“…18 Carbaryl was selected to represent carbamates since it is applied extensively in the UK and elsewhere,6,10,15 has been proposed as an alternative to dichlorvos in Ðsh farming,19 and because of its hydrophobic nature (log octanol/water partition coefficient (log 2É36), sig-K ow ) niÐcant bioaccumulation by mussels is predicted. 5,20 The inhibition of AChE activity in organisms exposed to these compounds can be readily measured. 18,21,22 We have therefore assayed the activity of this enzyme in the gills of mussels exposed to dichlorvos and carbaryl in an attempt to establish a mechanistic link between physiological response and enzyme activity.…”

Section: Organophosphate and Carbamate Pesticidesmentioning

confidence: 99%

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Effect of Neurotoxic Pesticides on the Feeding Rate of Marine Mussels (Mytilus edulis)

et al. 1997

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:The e †ects of selected neurotoxic pesticides on the feeding rate of marine mussels (Mytilus edulis) were determined. Two organochlorine pesticides, lindane and endrin, two acetylcholinesterase-inhibiting compounds, dichlorvos and carbaryl and two pyrethroids, Ñucythrinate and permethrin, were studied. No evidence was found for any speciÐc neurotoxic e †ect of the organochlorines and pyrethroids on feeding efficiency. In contrast, dichlorvos and carbaryl inhibited the enzyme acetylcholinesterase in mussel gills and were more toxic to feeding efficiency than could be explained by a narcotic mechanism of toxicity alone. Dichlorvos also caused clear behavioural changes in the mussels. The signiÐcance of these observations for the application of mussels to impact assessment in the marine environment is discussed.

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Section: Organochlorine Compoundsmentioning

confidence: 95%

Section: Organophosphate and Carbamate Pesticidesmentioning

confidence: 99%

Effect of Neurotoxic Pesticides on the Feeding Rate of Marine Mussels (Mytilus edulis)

et al. 1997

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“…Thus, a permanent Fe flux from the extracellular medium to the cytoplasm is generated, and the nature and magnitude of the Fe trafficking and Fe toxicity features in the tissues are still under investigation. The potential for ROS production in molluscs is particularly significant in the lipid rich digestive gland (DG) which is a primary accumulation site for ingested transition metals (Geyer et al, 1982;González et al, 2008a, b). Moreover, hemocyte cells seem to be Fe sinks in invertebrates, and are possibly good indicators of the availability of Fe to animals.…”

Section: Introductionmentioning

confidence: 99%

Exposure to excess dissolved iron in vivo affects oxidative status in the bivalve Mya arenaria

González

Abele

Puntarulo

2010

Comparative Biochemistry and Physiology Part C: Toxicology &

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The effect of in vivo Fe exposure on the oxidative metabolism of the bivalve Mya arenaria was studied. Fe was supplemented in natural seawater and resulted in a significant increase in the total Fe content in the bivalve digestive gland (DG) between 9 to 17 days of exposure. Mortality of treated animals increased drastically after day 18. Oxidative stress conditions were characterized in DG through assessment of the generation of reactive oxygen species (ROS) and ascorbyl radical (A•) content. Both parameters were affected following a biphasic profile showing significant increases by days 2 and 9 of Fe exposure. The content of 2-thiobarbituric acid reactive substances (TBARS) was significantly increased over control values by days 2, 9 and 17 of treatment. The labile Fe pool (LIP) in isolated DG was elevated over control values by day 7, and maintained this increase until day 17 of Fe exposure. The content of NO, assessed by EPR spin trapping, was 60% lower in DG of animals exposed for 2 days to Fe than in control values, with no further changes. The biphasic profile of oxidative stress response to Fe exposure in DG suggests that at early stages of Fe supplementation the cellular control mechanisms, such as CAT activity, were operative to limit oxidative damage, but further Fe exposure overwhelmed these abilities. Moreover, the second phase could be understood as the consequence of the exhaustion of cellular protective systems that could also involve NO.

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“…In no case does BCF exceed 10, a value that is three or even four orders of magnitude lower than that recorded in Mytilus sp. for persistent organic pollutants such as PCBs or PAHs (Geyer et al 1982, Baumard et al 1999. This is understandable, given the very low partition coefficient of bmimCl (-1.44), which is due to its purely ionic character (Stepnowski, Storoniak 2005).…”

Section: Resultsmentioning

confidence: 91%

“…are frequently used as bioindicators of contamination in coastal seawaters, mainly because of their very effective accumulation of many chemical pollutants (Geyer et al 1982, Baumard et al 1999, Rainbow et al 2004. Table 3 lists the experimental data regarding the bioconcentration of bmimCl by M. trossulus.…”

Section: Resultsmentioning

confidence: 99%

Bioaccumulation of 1-butyl-3-methylimidazolium chloride ionic liquid in a simple marine trophic chain

Nędzi

Latała

Nichthauser

et al. 2013

Oceanological and Hydrobiological Studies

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This study focused on the bioaccumulation intensities of the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride (bmimCl) by two invertebrates: Mytilus trossulus and Balanus improvisus and the green alga Chlorella vulgaris. The bioconcentration of bmimCl by two invertebrates was tested in the contaminated water, both with and without the presence of green algae previously exposed to the bmimCl. The experimentally obtained bioconcentration factors (BCFs) are quite low and do not exceed the value of 10. The presence of contaminated C. vulgaris in the water induces an increase in BCF of barnacles up to 80% in comparison to barnacles exposed only to contaminated water. Detoxication of M. trossulus may be more effective in the presence of higher IL concentrations. BCFs for hard tissues of the mussel indicates an exclusively physical sorption mechanism on the mineral surface.

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Prediction of ecotoxicological behaviour of chemicals: Relationship between physico-chemical properties and bioaccumulation of organic chemicals in the mussel Mytilus edulis

Cited by 166 publications

References 56 publications

Effect of Neurotoxic Pesticides on the Feeding Rate of Marine Mussels (Mytilus edulis)

Effect of Neurotoxic Pesticides on the Feeding Rate of Marine Mussels (Mytilus edulis)

Exposure to excess dissolved iron in vivo affects oxidative status in the bivalve Mya arenaria

Bioaccumulation of 1-butyl-3-methylimidazolium chloride ionic liquid in a simple marine trophic chain

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