Prediction of Early Response to Chemotherapy in Breast Cancer Liver Metastases by Diffusion-Weighted MR Imaging

Abstract

Objective: To determine whether change in apparent diffusion coefficient value could predict early response to chemotherapy in breast cancer liver metastases. Materials and Methods: We retrospectively studied 42 patients (86 lesions) with breast cancer liver metastases who had undergone conventional magnetic resonance imaging and diffusion-weighted imaging (b = 0.700 s/mm 2 ) before and after chemotherapy. Maximum diameter and mean apparent diffusion coefficient value (×10 −3 mm 2 /s) of liver metastases from breast cancer were evaluated. The grouping reference was based on magnetic resonance imaging according to Response Evaluation Criteria in Solid Tumors (RECIST). Analysis of variance and receiver–operating characteristic analyses were performed. Results: Eighty-six metastases were classified as 40 responders and 46 nonresponders. A statistically significant correlation was found between prechemotherapy and postchemotherapy apparent diffusion coefficient values in responders, which were 0.9 ± 0.16 × 10 −3 mm 2 /s, 1.05 ± 0.12 × 10 −3 mm 2 /s, 1.26 ± 0.12 × 10 −3 mm 2 /s, and 1.33 ± 0.87 × 10 −3 mm 2 /s, respectively. No statistically significant difference was found between prechemotherapy and postchemotherapy apparent diffusion coefficient values in nonresponders. Differences were statistically significant between responders and nonresponders at prechemotherapy, 2 weeks after chemotherapy, and 4 weeks after chemotherapy ( P = 0.014, P = .001, and P = .000, respectively). Receiver operating characteristic curves showed that apparent diffusion coefficient values could predict treatment response early at 2 weeks after chemotherapy with 64.5% sensitivity and 91.8% specificity. Conclusion: The change in apparent diffusion coefficient value may be a sensitive indicator to predict early response to chemotherapy in breast cancer liver metastases.

Design, Synthesis, and Antiproliferative Activities of 1,3‐Disubstituted 2‐Thioxoimidazolidin‐4‐one Derivatives against HepG2 and MCF‐7 Cells

“…1 H NMR (DMSO-d6) (E-isomer, 74.14 %) δ: 2.27 (s, 3H, OCOCH 3 ), 2.40 (s, 3H, CH 3 ), 3.88 (s, 2H, CH 2 of imidazole), 7.76 (s, 1H, ArÀ H), 8.06 (s, 1H, ArÀ H), 12.03 (br-s, 1H, NH) ppm. 13 12).…”

The Value of MR-DWI and T1 Mapping in Indicating Radiation-Induced Soft Tissue Injury

“…Magnetic resonance diffusion-weighted imaging (MR-DWI) provides quantitative parameters-an apparent diffusion coefficient (ADC) that can quantitatively reflect changes in the microstructure and function of tissues and organs. Studies have shown that the change of ADC value may be a sensitive indicator to predict the early response of breast cancer liver metastasis chemotherapy (5) and predict the local recurrence of rectal cancer (6). The study of the feasibility of the ADC-based radioimmunology model for predicting pelvic lymph node metastasis in patients with stage IB-IIA cervical squamous cell carcinoma shows that the radioimmunology model is a non-invasive preoperative prediction tool, which may have a higher predictive effect than clinical and radiological factors (7).…”

Anti-Liver and Anti-Breast Cancer Activities of Novel 2-Thioxo-4-Imidazolidinone Derivatives

“…Breast cancer liver metastases are associated with a poor prognosis [1]. Chemotherapy for breast cancer and liver cancer kills cancer cells by using anticancer medicines that have negative side effects [2]. As a result, research and production of new anti-liver and anti-breast cancer agents with less side effects is still ongoing.…”