Prediction of Early Recurrence After Acute Ischemic Stroke

Abstract

IMPORTANCE Approximately half of recurrent strokes occur within days and weeks of an ischemic stroke. It is imperative to identify patients at imminent risk of recurrent stroke because recurrent events lead to prolonged hospitalization, worsened functional outcome, and increased mortality. OBJECTIVE To test the validity of a prognostic score that was exclusively developed to predict early risk of stroke recurrence in a multicenter setting. DESIGN, SETTING, AND PARTICIPANTS This hospital-based cohort study examined patients with and without magnetic resonance imaging-confirmed recurrent stroke within 90 days after an ischemic stroke. The study was performed at 3 teaching hospitals in the United States, Brazil, and South Korea and comprised adult patients admitted within 72 hours of symptom onset with a magnetic resonance imaging-confirmed diagnosis of acute ischemic stroke. Recruitment to the US cohort was performed from

Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence

“…Tools to predict early stroke recurrence integrate only clinical and/or imaging information, but accuracy might improve taking laboratory parameters into account. 85 86 Therefore, vWF might serve as a potential candidate given its important pathophysiologic role as acute phase protein and in LAA, where stroke recurrence is deemed to be highest. We still lack confirming data, but given the fact that stroke recurrence is highest shortly after stroke, it would be desirable to gain new data on early stroke recurrence with respect to vWF levels.…”

Risk factors for early and late recurrent ischemic strokes

“…For Western countries, the first 5year cumulative incidence of stroke recurrence ranges from 16 to 30% [3][4][5]. About 50% of patients surviving an ischemic stroke or TIA have an increased risk of recurrent stroke within a few days or weeks of the initial insult, with the highest risk during the first week [6]. As the risk of recurrent stroke is most prominent in the first few months after stroke, it is important to identify factors associated with early recurrence in order to establish effective treatments for secondary stroke prevention [7].…”

Clinical relevance of abnormal neuroimaging findings and long‐term risk of stroke recurrence

“…We recruited a total of 959 consecutive participants with acute ischaemic stroke as the derivation cohort (mean age, 66 AE 12 years; median initial National Institutes of Health Stroke Scale score, 3 [1][2][3][4][5][6]). Mean follow-up duration was 31 AE 15 months and 727 (76%) participants had a complete 2-year follow-up.…”