2021
DOI: 10.3390/genes12040462
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Prediction of Early Childhood Caries Based on Single Nucleotide Polymorphisms Using Neural Networks

Abstract: Background: Several genes and single nucleotide polymorphisms (SNPs) have been associated with early childhood caries. However, they are highly age- and population-dependent and the majority of existing caries prediction models are based on environmental and behavioral factors only and are scarce in infants. Methods: We examined 6 novel and previously analyzed 22 SNPs in the cohort of 95 Polish children (48 caries, 47 caries-free) aged 2–3 years. All polymorphisms were genotyped from DNA extracted from oral ep… Show more

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Cited by 18 publications
(22 citation statements)
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“…Numerous environmental and individual risk factors are responsible for this disorder’s occurrence and development. These components are related e.g., to the genetic factors, the transmission of germs between hosts, bacterial flora, flow rate and composition of saliva, hygienic and dietary habits, socioeconomic status, parental education, and oral health care availability [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Numerous environmental and individual risk factors are responsible for this disorder’s occurrence and development. These components are related e.g., to the genetic factors, the transmission of germs between hosts, bacterial flora, flow rate and composition of saliva, hygienic and dietary habits, socioeconomic status, parental education, and oral health care availability [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Ref. [ 14 ] proposed a Generalized regression neural network model for dental caries prediction among the Geriatric residents of Liaoning (China). This study yielded an accuracy, sensitivity, specificity, and AUC-ROC values of 77.29%, 85.16%, 70.27% and 0.626, respectively, while our model displayed higher values, as described in the model evaluation result section.…”
Section: Resultsmentioning
confidence: 99%
“…Liu, L. et al [ 13 ] constructed a generalized regression neural network (GRNN) model to predict caries among residents of Liaoning, China. Using regression on some highly correlated data tends to cause spurious results and overfitting [ 14 ].…”
Section: Related Workmentioning
confidence: 99%
“…Articles without complete texts, narrative reviews, scoping reviews, letters to the editor, opinion letters, case reports, brief communications, conference proceedings, and non-English language articles (84 articles) were all omitted ( Figure 1 ). Finally, only 25 papers met the qualifying requirements [ 3 , 7 , 10 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”
Section: Methodsmentioning
confidence: 99%